Nitrogen-containing bisphosphonates inhibit cell cycle progression in human melanoma cells (Q41988099)

14 October 2017

Nitrogen-containing bisphosphonates inhibit cell cycle progression in human melanoma cells (English)

1 reference

14 October 2017

A-M Forsea

1

1 reference

14 October 2017

C Müller

2

1 reference

14 October 2017

C Riebeling

3

1 reference

14 October 2017

C E Orfanos

4

1 reference

14 October 2017

C C Geilen

5

1 reference

14 October 2017

language of work or name

English

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publication date

1 August 2004

1 reference

British Journal of Cancer

14 October 2017

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14 October 2017

91

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14 October 2017

4

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14 October 2017

803-810

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https://scigraph.springernature.com/pub.10.1038/sj.bjc.6602052

14 October 2017

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Nitrogen-containing bisphosphonates induce S-phase cell cycle arrest and apoptosis of myeloma cells by activating MAPK pathway and inhibiting mevalonate pathway

5 June 2018

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The antitumor potential of bisphosphonates

5 June 2018

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Antitumor effects of bisphosphonates

5 June 2018

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The bisphosphonate pamidronate induces apoptosis in human melanoma cells in vitro.

5 June 2018

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The bisphosphonate zoledronic acid impairs Ras membrane [correction of impairs membrane] localisation and induces cytochrome c release in breast cancer cells

5 June 2018

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Bisphosphonates in the treatment of bone metastases

5 June 2018

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Actions of bisphosphonates in animal models of breast cancer

5 June 2018

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Development of bisphosphonates

5 June 2018

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Timing of cyclin D1 expression within G1 phase is controlled by Rho.

5 June 2018

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Ras and Rho regulation of the cell cycle and oncogenesis

5 June 2018

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The bisphosphonate ibandronate promotes apoptosis in MDA-MB-231 human breast cancer cells in bone metastases.

5 June 2018

1 reference

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Chemical and biological prerequisites for novel bisphosphonate molecules: results of comparative preclinical studies

5 June 2018

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The bisphosphonate, zoledronic acid, induces apoptosis of breast cancer cells: evidence for synergy with paclitaxel

5 June 2018

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Rho signals to cell growth and apoptosis

5 June 2018

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Nitrogen-bisphosphonates block retinoblastoma phosphorylation and cell growth by inhibiting the cholesterol biosynthetic pathway in a keratinocyte model for esophageal irritation.

5 June 2018

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Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates.

5 June 2018

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Ras and Rho GTPases: a family reunion

5 June 2018

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Genomic analysis of metastasis reveals an essential role for RhoC

5 June 2018

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Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298.

5 June 2018

1 reference

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Cellular and molecular mechanisms of action of bisphosphonates

5 June 2018

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Bisphosphonates induce apoptosis in human breast cancer cell lines

5 June 2018

1 reference

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Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase

5 June 2018

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Lovastatin inhibits G1/S transition of normal human B-lymphocytes independent of apoptosis

5 June 2018

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Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs

5 June 2018

1 reference

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The chemoresistance of human malignant melanoma: an update.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364766

Molecular mechanisms of action of bisphosphonates.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364766

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

5 June 2018

1 reference

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Induction of ceramide-mediated apoptosis by the anticancer phospholipid analog, hexadecylphosphocholine

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364766

Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364766

In vitro cytoreductive effects on multiple myeloma cells induced by bisphosphonates

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364766

The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364766

Bisphosphonates induce apoptosis in human myeloma cell lines: a novel anti-tumour activity.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364766

Pharmacokinetics of pamidronate disodium in patients with cancer with normal or impaired renal function

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364766

Bisphosphonates: preclinical aspects and use in osteoporosis

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364766

Nitrogen containing bisphosphonates induce apoptosis and inhibit the mevalonate pathway, impairing Ras membrane localization in prostate cancer cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364766

Highly potent geminal bisphosphonates. From pamidronate disodium (Aredia) to zoledronic acid (Zometa).

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364766

Identification of a bisphosphonate that inhibits isopentenyl diphosphate isomerase and farnesyl diphosphate synthase

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364766

Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364766

The bisphosphonate pamidronate is a potent inhibitor of human osteosarcoma cell growth in vitro

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364766

Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364766

Bisphosphonate treatment inhibits the growth of prostate cancer cells

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364766

Rho GTPases are over-expressed in human tumors.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364766

Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2364766

The clearance and bioavailability of pamidronate in patients with breast cancer and bone metastases

18 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.BJC.6602052

Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases

21 January 2018

1 reference

12 December 2020

Bisphosphonates--mechanisms of action in multiple myeloma

1 reference

12 December 2020

Bisphosphonates are incorporated into adenine nucleotides by human aminoacyl-tRNA synthetase enzymes

1 reference

12 December 2020

Geranylgeranylated rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells

1 reference

12 December 2020

The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway

1 reference

12 December 2020

Bisphosphonates act directly on the osteoclast to induce caspase cleavage of mst1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase

1 reference

12 December 2020

Hematologic malignancies: new developments and future treatments

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.BJC.6602052

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/SJ.BJC.6602052

0 references

1 reference

14 October 2017

PubMed publication ID

15280922

1 reference