Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase (Q42022306)

15 October 2017

Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase (English)

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15 October 2017

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17

Kendall N Houk

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15 October 2017

Mariam Aghajan

1

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15 October 2017

Nao Jonai

2

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15 October 2017

Karin Flick

3

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15 October 2017

Fei Fu

4

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15 October 2017

Manlin Luo

5

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15 October 2017

Xiaolu Cai

6

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15 October 2017

Ikram Ouni

7

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15 October 2017

Nathan Pierce

8

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15 October 2017

Xiaobo Tang

9

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15 October 2017

Brett Lomenick

10

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15 October 2017

Robert Damoiseaux

11

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15 October 2017

Rui Hao

12

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15 October 2017

Pierre M Del Moral

13

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15 October 2017

Rati Verma

14

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15 October 2017

Ying Li

15

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15 October 2017

Cheng Li

16

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15 October 2017

Michael E Jung

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15 October 2017

Ning Zheng

19

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15 October 2017

Lan Huang

20

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15 October 2017

Raymond J Deshaies

21

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15 October 2017

Peter Kaiser

22

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15 October 2017

Jing Huang

23

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15 October 2017

27 June 2010

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15 October 2017

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28

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15 October 2017

7

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15 October 2017

738-742

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https://scigraph.springernature.com/pub.10.1038/nbt.1645

15 October 2017

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Targeting the p27 E3 ligase SCF(Skp2) results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy

5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth

5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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Ras, PI(3)K and mTOR signalling controls tumour cell growth

5 June 2018

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5 June 2018

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Features of selective kinase inhibitors

5 June 2018

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Function and regulation of cullin-RING ubiquitin ligases

5 June 2018

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Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips

5 June 2018

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The TOR pathway: a target for cancer therapy

5 June 2018

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Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

5 June 2018

1 reference

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Functional discovery via a compendium of expression profiles

5 June 2018

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SCF(Met30)-mediated control of the transcriptional activator Met4 is required for the G(1)-S transition

5 June 2018

1 reference

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SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

5 June 2018

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Therapeutic tumor-specific cell cycle block induced by methionine starvation in vivo

5 June 2018

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The Effect of Replacement of Methionine by Homocystine on Survival of Malignant and Normal Adult Mammalian Cells in Culture

5 June 2018

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Target identification using drug affinity responsive target stability (DARTS)

5 June 2018

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The yeast ubiquitin ligase SCFMet30: connecting environmental and intracellular conditions to cell division

17 August 2018

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Proteolysis-independent regulation of the transcription factor Met4 by a single Lys 48-linked ubiquitin chain.

17 August 2018

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Imatinib GIST keeps finding new indications: successful treatment of dermatofibrosarcoma protuberans by targeted inhibition of the platelet-derived growth factor receptor

17 August 2018

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An integrated mass spectrometry-based proteomic approach: quantitative analysis of tandem affinity-purified in vivo cross-linked protein complexes (QTAX) to decipher the 26 S proteasome-interacting network.

17 August 2018

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A tandem affinity tag for two-step purification under fully denaturing conditions: application in ubiquitin profiling and protein complex identification combined with in vivocross-linking

21 January 2018

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A novel small-molecule inhibitor of NF-kappaB signaling

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/20581845

12 December 2020

inferred from PubMed ID database lookup

Rapamycin-mediated G1 arrest involves regulation of the Cdk inhibitor Sic1 in Saccharomyces cerevisiae

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PubMed

https://pubmed.ncbi.nlm.nih.gov/20581845

12 December 2020

inferred from PubMed ID database lookup

Composite synthetic lethal identification of membrane traffic inhibitors

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7 January 2021

Gene ontology: tool for the unification of biology

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7 January 2021

Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae

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7 January 2021

Destabilization of binding to cofactors and SCFMet30 is the rate-limiting regulatory step in degradation of polyubiquitinated Met4

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7 January 2021

A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p

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7 January 2021

In vitro reconstitution of SCF substrate ubiquitination with purified proteins

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7 January 2021

A PCR-based strategy to generate yeast strains expressing endogenous levels of amino-terminal epitope-tagged proteins

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7 January 2021

Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry

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7 January 2021

Identifiers

DOI

10.1038/NBT.1645

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15 October 2017

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15 October 2017

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