Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements (Q42053294)

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scientific article published on January 2005

Language	Label	Description	Also known as
English	Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements	scientific article published on January 2005

Statements

scholarly article

1 reference

Europe PubMed Central

15 October 2017

Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements (English)

1 reference

Europe PubMed Central

15 October 2017

author name string

Lauren M Cagen

1

1 reference

Europe PubMed Central

15 October 2017

Xiong Deng

2

1 reference

Europe PubMed Central

15 October 2017

Henry G Wilcox

3

1 reference

Europe PubMed Central

15 October 2017

Edwards A Park

4

1 reference

Europe PubMed Central

15 October 2017

Rajendra Raghow

5

1 reference

Europe PubMed Central

15 October 2017

Marshall B Elam

6

1 reference

Europe PubMed Central

15 October 2017

language of work or name

0 references

publication date

1 January 2005

1 reference

Europe PubMed Central

15 October 2017

number of pages

10

1 reference

based on heuristic

inferred from page(s)

Biochemical Journal

1 reference

Europe PubMed Central

15 October 2017

385

1 reference

Europe PubMed Central

15 October 2017

207-216

1 reference

Europe PubMed Central

15 October 2017

Pt 1

1 reference

Europe PubMed Central

15 October 2017

Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134689

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Selective association of sterol regulatory element-binding protein isoforms with target promoters in vivo

1 reference

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Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis

1 reference

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O-GlcNAc modification is an endogenous inhibitor of the proteasome

1 reference

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Down-regulation of Sp1 activity through modulation of O-glycosylation by treatment with a low glucose mimetic, 2-deoxyglucose.

1 reference

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Protein-tyrosine phosphatase 1B as new activator for hepatic lipogenesis via sterol regulatory element-binding protein-1 gene expression

1 reference

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Coactivator-dependent acetylation stabilizes members of the SREBP family of transcription factors.

1 reference

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5 June 2018

Role of Sp1 in insulin regulation of gene expression

1 reference

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5 June 2018

Regulation of the activity of Sp1-related transcription factors.

1 reference

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Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase

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Stimulation of acetyl-CoA carboxylase gene expression by glucose requires insulin release and sterol regulatory element binding protein 1c in pancreatic MIN6 beta-cells

1 reference

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Induction of human liver X receptor alpha gene expression via an autoregulatory loop mechanism

1 reference

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The emerging significance of O-GlcNAc in cellular regulation

1 reference

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Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis

1 reference

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5 June 2018

Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter

1 reference

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Polyunsaturated fatty acid regulation of gene transcription: a molecular mechanism to improve the metabolic syndrome

1 reference

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Regulation of gene expression by SREBP and SCAP.

1 reference

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5 June 2018

Role of LXRs in control of lipogenesis

1 reference

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Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

1 reference

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Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation

1 reference

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5 June 2018

Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134689

5 June 2018

Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action

1 reference

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5 June 2018

Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134689

5 June 2018

MAP kinases Erk1/2 phosphorylate sterol regulatory element-binding protein (SREBP)-1a at serine 117 in vitro

1 reference

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The roles of sterol regulatory element-binding proteins in the transactivation of the rat ATP citrate-lyase promoter.

1 reference

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Different sterol regulatory element-binding protein-1 isoforms utilize distinct co-regulatory factors to activate the promoter for fatty acid synthase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134689

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Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134689

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Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

1 reference

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Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes

1 reference

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A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

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Interaction between the two ubiquitously expressed transcription factors NF-Y and Sp1

1 reference

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Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice

1 reference

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Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.

1 reference

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Sterol regulation of acetyl coenzyme A carboxylase promoter requires two interdependent binding sites for sterol regulatory element binding proteins

1 reference

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Promoter selective transcriptional synergy mediated by sterol regulatory element binding protein and Sp1: a critical role for the Btd domain of Sp1.

1 reference

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Reduced O glycosylation of Sp1 is associated with increased proteasome susceptibility

1 reference

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Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

1 reference

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Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells

1 reference

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Identification of an inverted CCAAT box motif in the fatty-acid synthase gene as an essential element for modification of transcriptional regulation by cAMP.

1 reference

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Insulin promotes the biosynthesis and secretion of apolipoprotein B-48 by altering apolipoprotein B mRNA editing

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Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13

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Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain

1 reference

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Domains of transcription factor Sp1 required for synergistic activation with sterol regulatory element binding protein 1 of low density lipoprotein receptor promoter

1 reference

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O-glycosylation of Sp1 and transcriptional regulation of the calmodulin gene by insulin and glucagon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134689

17 August 2018

Liver X receptors interact with corepressors to regulate gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134689

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High glucose and insulin promote O-GlcNAc modification of proteins, including alpha-tubulin

1 reference

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Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c

1 reference

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Regulation of the rat SREBP-1c promoter in primary rat hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134689

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Direct demonstration of rapid degradation of nuclear sterol regulatory element-binding proteins by the ubiquitin-proteasome pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134689

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Functional interaction between sterol regulatory element-binding protein-1c, nuclear factor Y, and 3,5,3'-triiodothyronine nuclear receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1134689

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Cholesterol biosynthesis from lanosterol. A concerted role for Sp1 and NF-Y-binding sites for sterol-mediated regulation of rat 7-dehydrocholesterol reductase gene expression

1 reference

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Insulin deprivation leads to deficiency of Sp1 transcription factor in H-411E hepatoma cells and in streptozotocin-induced diabetic ketoacidosis in the rat.

1 reference

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Synergistic activation of transcription by nuclear factor Y and sterol regulatory element binding protein

1 reference

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Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/15330762

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ADD1/SREBP-1c mediates insulin-induced gene expression linked to the MAP kinase pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/15330762

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The LXRs: a new class of oxysterol receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15330762

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ20040162

1 reference

Europe PubMed Central

15 October 2017

1 reference

Europe PubMed Central

15 October 2017

1 reference

Europe PubMed Central

15 October 2017

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