The transcription inhibitor lipiarmycin blocks DNA fitting into the RNA polymerase catalytic site (Q42118811)

16 October 2017

The transcription inhibitor lipiarmycin blocks DNA fitting into the RNA polymerase catalytic site (English)

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16 October 2017

Konstantin Brodolin

4

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author name string

Audrey Tupin

series ordinal

1

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16 October 2017

Maxime Gualtieri

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2

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16 October 2017

Jean-Paul Leonetti

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3

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16 October 2017

language of work or name

English

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publication date

18 June 2010

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16 October 2017

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16 October 2017

29

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16 October 2017

15

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16 October 2017

2527-2537

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describes a project that uses

16 October 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2928680/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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29 May 2018

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29 May 2018

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Transcription inactivation through local refolding of the RNA polymerase structure

29 May 2018

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Rifamycins do not function by allosteric modulation of binding of Mg2+ to the RNA polymerase active center

29 May 2018

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Lipiarmycin targets RNA polymerase and has good activity against multidrug-resistant strains of Mycobacterium tuberculosis

29 May 2018

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29 May 2018

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29 May 2018

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Progress in targeting bacterial transcription

29 May 2018

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The role of the lid element in transcription by E. coli RNA polymerase

29 May 2018

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Real-time characterization of intermediates in the pathway to open complex formation by Escherichia coli RNA polymerase at the T7A1 promoter

29 May 2018

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Mode of action of the microbial metabolite GE23077, a novel potent and selective inhibitor of bacterial RNA polymerase

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Kinetic studies and structural models of the association of E. coli sigma(70) RNA polymerase with the lambdaP(R) promoter: large scale conformational changes in forming the kinetically significant intermediates

29 May 2018

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Structural basis of transcription initiation: an RNA polymerase holoenzyme-DNA complex

29 May 2018

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Structural basis of transcription initiation: RNA polymerase holoenzyme at 4 A resolution

29 May 2018

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Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 A resolution

29 May 2018

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Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution

29 May 2018

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Structural mechanism for rifampicin inhibition of bacterial rna polymerase

29 May 2018

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Crystal structure of Thermus aquaticus core RNA polymerase at 3.3 A resolution.

29 May 2018

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The functional and regulatory roles of sigma factors in transcription

29 May 2018

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Protein-nucleic acid interactions during open complex formation investigated by systematic alteration of the protein and DNA binding partners

29 May 2018

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DNA footprints of the two kinetically significant intermediates in formation of an RNA polymerase-promoter open complex: evidence that interactions with start site and downstream DNA induce sequential conformational changes in polymerase and DNA.

29 May 2018

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Inhibition by lipiarmycin of bacteriophage growth in Bacillus subtilis

29 May 2018

1 reference

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Changes in the DNA structure of the lac UV5 promoter during formation of an open complex with Escherichia coli RNA polymerase

29 May 2018

1 reference

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Kinetics of open complex formation between Escherichia coli RNA polymerase and the lac UV5 promoter. Evidence for a sequential mechanism involving three steps

29 May 2018

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Visualization and quantitative analysis of complex formation between E. coli RNA polymerase and an rRNA promoter in vitro

29 May 2018

1 reference

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DNA melting within stable closed complexes at the Escherichia coli rrnB P1 promoter

29 May 2018

1 reference

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Lipiarmycin: An antibiotic inhibiting nucleic acid polymerases

29 May 2018

1 reference

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Lipiarmycin-resistant ribonucleic acid polymerase mutants of Bacillus subtilis

29 May 2018

1 reference

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Initiation of transcription in vitro is inhibited by lipiarmycin

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928680

Lipiarmycin, a new antibiotic from Actinoplanes. II. Isolation, chemical, biological and biochemical characterization.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928680

Structure-function analysis of the RNA polymerase cleft loops elucidates initial transcription, DNA unwinding and RNA displacement

29 May 2018

1 reference

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Mutation in the Bacillus subtilis RNA polymerase beta' subunit confers resistance to lipiarmycin

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928680

Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928680

Remodeling of the sigma70 subunit non-template DNA strand contacts during the final step of transcription initiation.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928680

The sigma 70 subunit of RNA polymerase induces lacUV5 promoter-proximal pausing of transcription

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928680

Crucial role of the RNA:DNA hybrid in the processivity of transcription

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928680

Transcription regulation by initiating NTP concentration: rRNA synthesis in bacteria.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928680

Intermediates in transcription initiation from the E. coli lac UV5 promoter

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928680

Mechanistic model of the elongation complex of Escherichia coli RNA polymerase

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928680

Frequency and characterisation of spontaneous lipiarmycin-resistant Enterococcus faecalis mutants selected in vitro

3 November 2018

1 reference

12 December 2020

A conserved zinc binding domain in the largest subunit of DNA-dependent RNA polymerase modulates intrinsic transcription termination and antitermination but does not stabilize the elongation complex

1 reference

12 December 2020

Lipiarmycin, a new antibiotic from Actinoplanes III. Mechanism of action

1 reference

12 December 2020

Region 3.2 of the sigma subunit contributes to the binding of the 3'-initiating nucleotide in the RNA polymerase active center and facilitates promoter clearance during initiation

1 reference

12 December 2020

The role of the largest RNA polymerase subunit lid element in preventing the formation of extended RNA-DNA hybrid

1 reference

12 December 2020

Lipiarmycin, a new antibiotic from Actinoplanes. II. Isolation, chemical, bilogical and biochemical characterization.

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.135

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/EMBOJ.2010.135

1 reference

16 October 2017

1 reference

16 October 2017

PubMed publication ID

20562828

1 reference