The cytoskeletal adaptor protein IQGAP1 regulates TCR-mediated signaling and filamentous actin dynamics. (Q42126397)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22573807%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

title

The cytoskeletal adaptor protein IQGAP1 regulates TCR-mediated signaling and filamentous actin dynamics (English)

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1 February 2020

0 references

7

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1 February 2020

8

Daniel D Billadeau

1 reference

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1 February 2020

author name string

Jacquelyn A Gorman

1

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1 February 2020

Alexander Babich

2

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1 February 2020

Christopher J Dick

3

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1 February 2020

Renee A Schoon

4

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1 February 2020

Alexander Koenig

5

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1 February 2020

Timothy S Gomez

6

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1 February 2020

language of work or name

English

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publication date

9 May 2012

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1 February 2020

published in

Journal of Immunology

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1 February 2020

volume

188

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1 February 2020

issue

12

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1 February 2020

page(s)

6135-6144

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Natural killer cell lytic granule secretion occurs through a pervasive actin network at the immune synapse

1 February 2020

cites work

1 reference

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The IQGAP1 protein is a calmodulin-regulated barbed end capper of actin filaments: possible implications in its function in cell migration

29 May 2018

1 reference

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Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex

29 May 2018

1 reference

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IQGAP1 involvement in MTOC and granule polarization in NK-cell cytotoxicity

29 May 2018

1 reference

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Protein kinase G signaling disrupts Rac1-dependent focal adhesion assembly in liver specific pericytes

29 May 2018

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Mutant K-Ras increases GSK-3β gene expression via an ETS-p300 transcriptional complex in pancreatic cancer

29 May 2018

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The interaction of IQGAPs with calmodulin-like proteins

29 May 2018

1 reference

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Mediation of T-cell activation by actin meshworks

29 May 2018

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NMR structure of the calponin homology domain of human IQGAP1 and its implications for the actin recognition mode

29 May 2018

1 reference

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A FAM21-containing WASH complex regulates retromer-dependent sorting

29 May 2018

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Review of the mechanism of processive actin filament elongation by formins

29 May 2018

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Myosin IIA associates with NK cell lytic granules to enable their interaction with F-actin and function at the immunological synapse

29 May 2018

1 reference

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IQGAPs in cancer: a family of scaffold proteins underlying tumorigenesis

29 May 2018

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Dynamin 2 regulates granule exocytosis during NK cell-mediated cytotoxicity

29 May 2018

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Tailoring T-cell receptor signals by proximal negative feedback mechanisms

29 May 2018

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T cell activation and the cytoskeleton: you can't have one without the other

29 May 2018

1 reference

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A role for CD8 in the developmental tuning of antigen recognition and CD3 conformational change

29 May 2018

1 reference

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Development of hepatocellular carcinoma in Iqgap2-deficient mice is IQGAP1 dependent

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

Get to grips: steering local actin dynamics with IQGAPs

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

IQGAP1 modulates activation of B-Raf

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

T-cell-receptor-dependent actin regulatory mechanisms.

29 May 2018

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Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

IQGAP1 stimulates actin assembly through the N-WASP-Arp2/3 pathway

29 May 2018

1 reference

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Microtubule plus end: a hub of cellular activities

29 May 2018

1 reference

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IQGAP1 in cellular signaling: bridging the GAP.

29 May 2018

1 reference

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The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly.

29 May 2018

1 reference

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Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling

29 May 2018

1 reference

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IQGAP1 is a scaffold for mitogen-activated protein kinase signaling

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

IQGAP1: a key regulator of adhesion and migration

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

Actin filament binding by a monomeric IQGAP1 fragment with a single calponin homology domain

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

IQGAP1 binds ERK2 and modulates its activity

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

IQGAP1 promotes cell motility and invasion

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

ROCK and Dia have opposing effects on adherens junctions downstream of Rho

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

Gastric hyperplasia in mice lacking the putative Cdc42 effector IQGAP1

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

IQGAP1 and calmodulin modulate E-cadherin function

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

The Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organization

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

TCR, LFA-1, and CD28 play unique and complementary roles in signaling T cell cytoskeletal reorganization.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

Identification of a putative effector for Cdc42Hs with high sequence similarity to the RasGAP-related protein IQGAP1 and a Cdc42Hs binding partner with similarity to IQGAP2

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

Identification of a human rasGAP-related protein containing calmodulin-binding motifs

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

Signal transduction during human natural killer cell activation: inositol phosphate generation and regulation by cyclic AMP.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

Effects of p56lck deficiency on the growth and cytolytic effector function of an interleukin-2-dependent cytotoxic T-cell line

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

Cutting Edge: mechanical forces acting on T cells immobilized via the TCR complex can trigger TCR signaling.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

Centrosome polarization delivers secretory granules to the immunological synapse.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

Arp2/3 activity is necessary for efficient formation of E-cadherin adhesive contacts

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

SLP-76 coordinates Nck-dependent Wiskott-Aldrich syndrome protein recruitment with Vav-1/Cdc42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

The actin cytoskeleton and cytotoxic T lymphocytes: evidence for multiple roles that could affect granule exocytosis-dependent target cell killing.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3370139

Binding of myosin essential light chain to the cytoskeleton-associated protein IQGAP1

17 August 2018

1 reference

12 December 2020

Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse

1 reference

12 December 2020

Roles of IQGAP1 in cell polarization and migration

1 reference

12 December 2020

TCR/CD28-stimulated actin dynamics are required for NFAT1-mediated transcription of c-rel leading to CD28 response element activation

1 reference

12 December 2020

High-resolution multicolor imaging of dynamic signaling complexes in T cells stimulated by planar substrates

1 reference

12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.1103487

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22573807%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22573807%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22573807%20AND%20SRC:MED&resulttype=core&format=json