From the traditional Chinese medicine plant Schisandra chinensis new scaffolds effective on HIV-1 reverse transcriptase resistant to non-nucleoside inhibitors. (Q42157376)

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English	From the traditional Chinese medicine plant Schisandra chinensis new scaffolds effective on HIV-1 reverse transcriptase resistant to non-nucleoside inhibitors.	scientific article

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2 March 2020

From the traditional Chinese medicine plant Schisandra chinensis new scaffolds effective on HIV-1 reverse transcriptase resistant to non-nucleoside inhibitors (English)

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2 March 2020

Schisandra chinensis

object named as

Schisandra chinensis

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traditional Chinese medicine

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object named as

traditional Chinese medicine

17 February 2024

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2

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2 March 2020

Claudia Del Vecchio

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2 March 2020

Francesca Esposito

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2 March 2020

Enzo Tramontano

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2 March 2020

Cristina Parolin

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Cristina Parolin

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2 March 2020

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Lijia Xu

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4 March 2015

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2 March 2020

The Journal of Microbiology

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288-293

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2 March 2020

https://scigraph.springernature.com/pub.10.1007/s12275-015-4652-0

0 references

Protective role of deoxyschizandrin and schisantherin A against myocardial ischemia-reperfusion injury in rats

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21 January 2018

Beneficial effects of schisandrin B on the cardiac function in mice model of myocardial infarction

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Identification of highly conserved residues involved in inhibition of HIV-1 RNase H function by Diketo acid derivatives

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Active site and allosteric inhibitors of the ribonuclease H activity of HIV reverse transcriptase

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21 January 2018

Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection - an update (1998 - 2007).

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21 January 2018

Identification of HIV-1 reverse transcriptase dual inhibitors by a combined shape-, 2D-fingerprint- and pharmacophore-based virtual screening approach.

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21 January 2018

Structural and biochemical effects of human immunodeficiency virus mutants resistant to non-nucleoside reverse transcriptase inhibitors

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21 January 2018

Hypericum hircinum L. components as new single-molecule inhibitors of both HIV-1 reverse transcriptase-associated DNA polymerase and ribonuclease H activities.

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21 January 2018

Simultaneous determination of eleven characteristic lignans in Schisandra chinensis by high-performance liquid chromatography

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21 January 2018

Traditional Chinese herbal medicine as a source of molecules with antiviral activity

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Drug discovery and natural products: end of an era or an endless frontier?

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21 January 2018

Resistance to nevirapine of HIV-1 reverse transcriptase mutants: loss of stabilizing interactions and thermodynamic or steric barriers are induced by different single amino acid substitutions.

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21 January 2018

Twenty-six years of anti-HIV drug discovery: where do we stand and where do we go?

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

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21 January 2018

Inhibition of ATR protein kinase activity by schisandrin B in DNA damage response

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21 January 2018

Pharmacology of Schisandra chinensis Bail.: an overview of Russian research and uses in medicine.

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21 January 2018

New anti-human immunodeficiency virus type 1 6-aminoquinolones: mechanism of action

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21 January 2018

Structural basis for drug resistance mechanisms for non-nucleoside inhibitors of HIV reverse transcriptase

1 reference

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21 January 2018

Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity

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21 January 2018

Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase

1 reference

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21 January 2018

HIV-1 RT-associated RNase H function inhibitors: Recent advances in drug development

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21 January 2018

6-[1-(4-Fluorophenyl)methyl-1H-pyrrol-2-yl)]-2,4-dioxo-5-hexenoic acid ethyl ester a novel diketo acid derivative which selectively inhibits the HIV-1 viral replication in cell culture and the ribonuclease H activity in vitro

1 reference

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21 January 2018

Anti-HIV-1 activity of lignans from the fruits of Schisandra rubriflora

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21 January 2018

New developments in natural products-based anti-AIDS research

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21 January 2018

Correlation between Antistress and Hepatoprotective Effects of Schisandra Lignans Was Related with Its Antioxidative Actions in Liver Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25740376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dibenzo[a,c]cyclooctadiene lignans of the genus Schisandra: importance, isolation and determination

1 reference

https://pubmed.ncbi.nlm.nih.gov/25740376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Schisandrin B as a hormetic agent for preventing age-related neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/25740376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A single conservative amino acid substitution in the reverse transcriptase of human immunodeficiency virus-1 confers resistance to (+)-(5S)-4,5,6,7-tetrahydro-5-methyl-6-(3-methyl-2-butenyl)imidazo[4,5, 1- jk][1,4]benzodiazepin-2(1H)-thione (TIBO R8

1 reference

https://pubmed.ncbi.nlm.nih.gov/25740376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro selection and molecular characterization of human immunodeficiency virus-1 resistant to non-nucleoside inhibitors of reverse transcriptase

1 reference

https://pubmed.ncbi.nlm.nih.gov/25740376

12 December 2020

based on heuristic

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HIV-1 Reverse Transcriptase Still Remains a New Drug Target: Structure, Function, Classical Inhibitors, and New Inhibitors with Innovative Mechanisms of Actions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25740376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of schizandrin in rat plasma by high-performance liquid chromatography-mass spectrometry and its application in rat pharmacokinetic studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/25740376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New Perspectives on How to Discover Drugs from Herbal Medicines: CAM's Outstanding Contribution to Modern Therapeutics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25740376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora

1 reference

https://pubmed.ncbi.nlm.nih.gov/25740376

12 December 2020

based on heuristic

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[Studies on Fructus schizandrae. I. Its effect on increased SGPT levels in animals caused by hepatotoxic chemical agents]

1 reference

https://pubmed.ncbi.nlm.nih.gov/25740376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-inflammatory activity of traditional Chinese medicinal herbs

1 reference

https://pubmed.ncbi.nlm.nih.gov/25740376

12 December 2020

based on heuristic

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Rapid complementation assays measuring replicative potential of human immunodeficiency virus type 1 envelope glycoprotein mutants

1 reference

https://pubmed.ncbi.nlm.nih.gov/25740376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological properties of Dibenzo[a,c]cyclooctene derivatives isolated from Fructus Schizandrae Chinensis III. Inhibitory effects on carbon tetrachloride-induced lipid peroxidation, metabolism and covalent binding of carbon tetrachloride to lipi

1 reference

https://pubmed.ncbi.nlm.nih.gov/25740376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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