Allosteric mechanisms in cytochrome P450 3A4 studied by high-pressure spectroscopy: pivotal role of substrate-induced changes in the accessibility and degree of hydration of the heme pocket. (Q42173769)

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scientific article published on 8 June 2007

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English	Allosteric mechanisms in cytochrome P450 3A4 studied by high-pressure spectroscopy: pivotal role of substrate-induced changes in the accessibility and degree of hydration of the heme pocket.	scientific article published on 8 June 2007

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31 December 2019

Allosteric mechanisms in cytochrome P450 3A4 studied by high-pressure spectroscopy: pivotal role of substrate-induced changes in the accessibility and degree of hydration of the heme pocket (English)

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31 December 2019

Dmitri R Davydov

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31 December 2019

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Bradley J Baas

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31 December 2019

Stephen G Sligar

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31 December 2019

James R Halpert

4

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31 December 2019

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8 June 2007

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31 December 2019

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31 December 2019

46

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31 December 2019

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31 December 2019

7852-7864

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31 December 2019

Mechanism of interactions of alpha-naphthoflavone with cytochrome P450 3A4 explored with an engineered enzyme bearing a fluorescent probe.

1 reference

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Structural basis for ligand promiscuity in cytochrome P450 3A4.

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Resolution of multiple substrate binding sites in cytochrome P450 3A4: the stoichiometry of the enzyme-substrate complexes probed by FRET and Job's titration

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Kinetics of dithionite-dependent reduction of cytochrome P450 3A4: heterogeneity of the enzyme caused by its oligomerization.

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26 October 2017

High pressure, a tool for exploring heme protein active sites

1 reference

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The interactions of nucleic acids at elevated hydrostatic pressure

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The effects of osmotic and hydrostatic pressures on macromolecular systems

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26 October 2017

Protein structure and dynamics at high pressure.

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26 October 2017

Antagonistic effects of hydrostatic pressure and osmotic pressure on cytochrome P-450cam spin transition

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29 May 2018

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Characterization of a cytochrome P450 from the acidothermophilic archaea Sulfolobus solfataricus

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P-450 binding to substrates camphor and linalool versus pressure.

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29 May 2018

Heme-pocket-hydration change during the inactivation of cytochrome P-450camphor by hydrostatic pressure

1 reference

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Pressure and temperature as tools for investigating the role of individual non-covalent interactions in enzymatic reactions Sulfolobus solfataricus carboxypeptidase as a model enzyme

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17 August 2018

Homotropic cooperativity of monomeric cytochrome P450 3A4 in a nanoscale native bilayer environment

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Conformational heterogeneity of cytochrome P450 3A4 revealed by high pressure spectroscopy.

1 reference

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17 August 2018

Reversible pressure deformation of a thermophilic cytochrome P450 enzyme (CYP119) and its active-site mutants

1 reference

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17 August 2018

Stabilization of P450 2B4 by its association with P450 1A2 revealed by high-pressure spectroscopy.

1 reference

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17 August 2018

Cooperativity in oxidations catalyzed by cytochrome P450 3A4.

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Thermodynamic studies of substrate binding and spin transitions in human cytochrome P-450 3A4 expressed in yeast microsomes.

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Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active site.

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High-pressure-induced transitions in microsomal cytochrome P450 2B4 in solution: evidence for conformational inhomogeneity in the oligomers.

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Conformational changes of cytochromes P-450cam and P-450lin induced by high pressure

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Hydrostatic pressure reverses osmotic pressure effects on the specificity of EcoRI-DNA interactions

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Cooperativity in Cytochrome P450 3A4

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1 reference

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High-pressure investigations of cytochrome P-450 spin and substrate binding equilibria

1 reference

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Effect of the tyrosine 96 hydrogen bond on the inactivation of cytochrome P-450cam induced by hydrostatic pressure

1 reference

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1 reference

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A central role for water in the control of the spin state of cytochrome P-450scc

1 reference

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Evaluation of atypical cytochrome P450 kinetics with two-substrate models: evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites

1 reference

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1 reference

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Identifiers

10.1021/BI602400Y

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31 December 2019

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31 December 2019

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31 December 2019

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