Mechanism of interactions of alpha-naphthoflavone with cytochrome P450 3A4 explored with an engineered enzyme bearing a fluorescent probe. (Q42173777)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17198380%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

title

Mechanism of interactions of alpha-naphthoflavone with cytochrome P450 3A4 explored with an engineered enzyme bearing a fluorescent probe (English)

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23 December 2019

4

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23 December 2019

author name string

Tamara N Tsalkova

series ordinal

1

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23 December 2019

Nadezhda Y Davydova

series ordinal

2

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23 December 2019

James R Halpert

series ordinal

3

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23 December 2019

language of work or name

English

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publication date

1 January 2007

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23 December 2019

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23 December 2019

volume

46

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23 December 2019

issue

1

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23 December 2019

page(s)

106-119

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Structural basis for ligand promiscuity in cytochrome P450 3A4.

23 December 2019

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26 October 2017

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26 October 2017

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Analysis of human cytochrome P450 3A4 cooperativity: construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kinetics

26 October 2017

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26 October 2017

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26 October 2017

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29 May 2018

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Modulation of rabbit and human hepatic cytochrome P-450-catalyzed steroid hydroxylations by alpha-naphthoflavone

29 May 2018

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29 May 2018

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17 August 2018

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17 August 2018

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17 August 2018

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17 August 2018

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17 August 2018

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17 August 2018

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17 August 2018

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17 August 2018

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17 August 2018

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17 August 2018

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Mapping proximity within proteins using fluorescence spectroscopy. A study of T4 lysozyme showing that tryptophan residues quench bimane fluorescence

17 August 2018

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17 August 2018

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17 August 2018

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17 August 2018

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Analysis of four residues within substrate recognition site 4 of human cytochrome P450 3A4: role in steroid hydroxylase activity and alpha-naphthoflavone stimulation.

17 August 2018

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17 August 2018

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17 August 2018

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17 August 2018

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17 August 2018

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17 August 2018

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12 December 2020

Functional reconstitution of cytochrome P-450scc with hemin activated with Woodward's reagent K. Formation of a hemeprotein cross-link

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Cytochrome P450 conformation and substrate interactions as probed by CO binding kinetics

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Differential mechanisms of cytochrome P450 inhibition and activation by alpha-naphthoflavone

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Alanine-scanning mutagenesis of a putative substrate recognition site in human cytochrome P450 3A4. Role of residues 210 and 211 in flavonoid activation and substrate specificity

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Variable path length and counter-flow continuous variation methods for the study of the formation of high-affinity complexes by absorbance spectroscopy. An application to the studies of substrate binding in cytochrome P450

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Identifiers

DOI

10.1021/BI061944P

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17198380%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17198380%20AND%20SRC:MED&resulttype=core&format=json

23 December 2019

1 reference