Synthetic fermentation of bioactive non-ribosomal peptides without organisms, enzymes or reagents (Q42186560)

18 October 2017

title

Synthetic fermentation of bioactive non-ribosomal peptides without organisms, enzymes or reagents (English)

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18 October 2017

Yi-Lin Huang

1

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18 October 2017

Jeffrey W Bode

series ordinal

2

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18 October 2017

publication date

7 September 2014

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18 October 2017

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18 October 2017

volume

6

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18 October 2017

issue

10

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18 October 2017

page(s)

877-884

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Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.

18 October 2017

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The peptide synthetase catalyzing cyclosporine production in Tolypocladium niveum is encoded by a giant 45.8-kilobase open reading frame

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Iterative, aqueous synthesis of beta3-oligopeptides without coupling reagents

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Discovery and development of telaprevir: an NS3-4A protease inhibitor for treating genotype 1 chronic hepatitis C virus

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Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bio

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Type II thioesterase restores activity of a NRPS module stalled with an aminoacyl-S-enzyme that cannot be elongated.

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Active-site modifications of adenylation domains lead to hydrolysis of upstream nonribosomal peptidyl thioester intermediates.

21 January 2018

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RNA-peptide fusions for the in vitro selection of peptides and proteins

21 January 2018

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Ribosomal synthesis of unnatural peptides

21 January 2018

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20 years of DNA-encoded chemical libraries.

21 January 2018

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The "One-Bead-One-Compound" Combinatorial Library Method

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High-throughput purification of compound libraries

21 January 2018

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AMIDE FORMATION BY DECARBOXYLATIVE CONDENSATION OF HYDROXYLAMINES AND α-KETOACIDS: N-[(1S)-1 PHENYLETHYL]-BENZENEACETAMIDE.

21 January 2018

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Asymmetric synthesis of enantiopure isoxazolidinone monomers for the synthesis of β-oligopeptides by chemoselective amide ligation

21 January 2018

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Asymmetric catalysis with peptides

21 January 2018

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A continuous assay of hepatitis C virus protease based on resonance energy transfer depsipeptide substrates

21 January 2018

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Directed evolution of the nonribosomal peptide synthetase AdmK generates new andrimid derivatives in vivo

21 January 2018

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A biosynthetic gene cluster for the acetyl-CoA carboxylase inhibitor andrimid

21 January 2018

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Synthesis of most polyene natural product motifs using just 12 building blocks and one coupling reaction

21 January 2018

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Synthesis of acyltrifluoroborates

21 January 2018

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12 December 2020

A reagent for the one-step preparation of potassium acyltrifluoroborates (KATs) from aryl- and heteroarylhalides

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12 December 2020

Harnessing the biosynthetic code: combinations, permutations, and mutations

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12 December 2020

Sequential α-ketoacid-hydroxylamine (KAHA) ligations: synthesis of C-terminal variants of the modifier protein UFM1

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12 December 2020

Identifiers

DOI

10.1038/NCHEM.2048

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18 October 2017

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