Mining and engineering natural-product biosynthetic pathways (Q33288081)

25 July 2017

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title

Mining and engineering natural-product biosynthetic pathways (English)

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25 July 2017

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Barrie Wilkinson

1

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25 July 2017

Jason Micklefield

series ordinal

2

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25 July 2017

language of work or name

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1 July 2007

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25 July 2017

Nature Chemical Biology

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25 July 2017

3

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25 July 2017

7

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25 July 2017

379-386

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https://scigraph.springernature.com/pub.10.1038/nchembio.2007.7

25 July 2017

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New aminocoumarin antibiotics from genetically engineered Streptomyces strains.

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Chemical genetics to chemical genomics: small molecules offer big insights

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The evolving role of natural products in drug discovery

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Biocatalysis in pharmaceutical preparation and alteration

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Production of the antimalarial drug precursor artemisinic acid in engineered yeast

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Platensimycin is a selective FabF inhibitor with potent antibiotic properties

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7 January 2021

Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)

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7 January 2021

Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.

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7 January 2021

Genome sequencing in microfabricated high-density picolitre reactors

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7 January 2021

A streamlined metabolic pathway for the biosynthesis of moenomycin A.

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Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining

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Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.

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Discovery of a new peptide natural product by Streptomyces coelicolor genome mining

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7 January 2021

A genomics-guided approach for discovering and expressing cryptic metabolic pathways.

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Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans

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Bacterial small-molecule signaling pathways

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Cloning and heterologous expression of isocyanide biosynthetic genes from environmental DNA.

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Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli

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Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli.

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Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella

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Shotgun cloning and heterologous expression of the patellamide gene cluster as a strategy to achieving sustained metabolite production

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Heterologous expression of a myxobacterial natural products assembly line in pseudomonads via red/ET recombineering.

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Metabolic engineering of Pseudomonas putida for methylmalonyl-CoA biosynthesis to enable complex heterologous secondary metabolite formation

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7 January 2021

GeneDesign: rapid, automated design of multikilobase synthetic genes

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Total synthesis of long DNA sequences: synthesis of a contiguous 32-kb polyketide synthase gene cluster.

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7 January 2021

Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes.

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7 January 2021

Loss of co-linearity by modular polyketide synthases: a mechanism for the evolution of chemical diversity

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7 January 2021

Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units

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Type II thioesterase restores activity of a NRPS module stalled with an aminoacyl-S-enzyme that cannot be elongated.

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7 January 2021

Active-site modifications of adenylation domains lead to hydrolysis of upstream nonribosomal peptidyl thioester intermediates.

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7 January 2021

Fancy footwork in the sequence space shuffle.

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7 January 2021

Designed divergent evolution of enzyme function

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7 January 2021

Rational design of peptide antibiotics by targeted replacement of bacterial and fungal domains

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7 January 2021

Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Modular organization of genes required for complex polyketide biosynthesis

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7 January 2021

Architecture of mammalian fatty acid synthase at 4.5 A resolution

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7 January 2021

Architecture of a fungal fatty acid synthase at 5 A resolution

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase.

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Structure of fungal fatty acid synthase and implications for iterative substrate shuttling

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7 January 2021

The structural basis for docking in modular polyketide biosynthesis

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7 January 2021

Harnessing the potential of communication-mediating domains for the biocombinatorial synthesis of nonribosomal peptides

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7 January 2021

Conformational Switches Modulate Protein Interactions in Peptide Antibiotic Synthetases

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7 January 2021

A mechanism-based aryl carrier protein/thiolation domain affinity probe

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Mechanism-based protein cross-linking probes to investigate carrier protein-mediated biosynthesis.

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Genetic engineering in Streptomyces roseosporus to produce hybrid lipopeptide antibiotics

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7 January 2021

Combinatorial biosynthesis of novel antibiotics related to daptomycin

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7 January 2021

Chemoenzymatic design of acidic lipopeptide hybrids: new insights into the structure-activity relationship of daptomycin and A54145.

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7 January 2021

Biomimetic catalysis of intermodular aminoacyl transfer

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7 January 2021

Functional and mechanistic analyses of biomimetic aminoacyl transfer reactions in de novo designed coiled coil peptides via rational active site engineering.

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7 January 2021

Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations.

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Mutational biosynthesis--a tool for the generation of structural diversity in the biosynthesis of antibiotics

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Mutasynthesis - uniting chemistry and genetics for drug discovery

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Unusual sugar biosynthesis and natural product glycodiversification

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Engineering deoxysugar biosynthetic pathways from antibiotic-producing microorganisms. A tool to produce novel glycosylated bioactive compounds

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Engineered urdamycin glycosyltransferases are broadened and altered in substrate specificity

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Exploiting the reversibility of natural product glycosyltransferase-catalyzed reactions

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Directed biosynthesis of alkaloid analogs in the medicinal plant Catharanthus roseus

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Redesign of a central enzyme in alkaloid biosynthesis.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Using unnatural protein fusions to engineer resveratrol biosynthesis in yeast and Mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2007.7

7 January 2021

Identifiers

DOI

10.1038/NCHEMBIO.2007.7

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Dimensions Publication ID

25 July 2017

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