Impaired Nef function is associated with early control of HIV-1 viremia (Q42208915)

18 October 2017

Impaired Nef function is associated with early control of HIV-1 viremia (English)

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18 October 2017

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18 October 2017

Takamasa Ueno

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Zabrina L Brumme

object named as

Zabrina L Brumme

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Bruce D. Walker

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object named as

Bruce D Walker

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Florencia Pereyra

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Eric S Rosenberg

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Eric S Daar

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Tristan Markle

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Anthony D Kelleher

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Toshiyuki Miura

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1

Xiaomei T Kuang

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Philip Mwimanzi

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Bemuluyigza Baraki

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Elizabeth Connick

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Gursev Anmole

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Susan Little

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18 October 2017

Xiaoguang Li

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18 October 2017

Aniqa Shahid

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18 October 2017

Anh Q Le

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18 October 2017

Louise Chong

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18 October 2017

Hua Qian

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Heiko Jessen

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Martin Markowitz

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18 October 2017

language of work or name

English

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publication date

25 June 2014

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10200-10213

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describes a project that uses

18 October 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4136354/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4

26 October 2017

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Differential impact of magnitude, polyfunctional capacity, and specificity of HIV-specific CD8+ T cell responses on HIV set point

26 October 2017

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HIV-1 Nef and T-cell activation: a history of contradictions

26 October 2017

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Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes

26 October 2017

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Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls

26 October 2017

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Extreme genetic fragility of the HIV-1 capsid.

26 October 2017

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HIV-1 conserved-element vaccines: relationship between sequence conservation and replicative capacity

26 October 2017

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Attenuation of multiple Nef functions in HIV-1 elite controllers

26 October 2017

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HIV-1 Nef: a multifaceted modulator of T cell receptor signaling

26 October 2017

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Role of transmitted Gag CTL polymorphisms in defining replicative capacity and early HIV-1 pathogenesis

26 October 2017

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Human leukocyte antigen (HLA) class I down-regulation by human immunodeficiency virus type 1 negative factor (HIV-1 Nef): what might we learn from natural sequence variants?

26 October 2017

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HLA-B may be more protective against HIV-1 than HLA-A because it resists negative regulatory factor (Nef) mediated down-regulation

26 October 2017

1 reference

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Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef

26 October 2017

1 reference

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Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix

26 October 2017

1 reference

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Immune selection in vitro reveals human immunodeficiency virus type 1 Nef sequence motifs important for its immune evasion function in vivo

26 October 2017

1 reference

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Elite controllers with low to absent effector CD8+ T cell responses maintain highly functional, broadly directed central memory responses

26 October 2017

1 reference

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Uncommon pathways of immune escape attenuate HIV-1 integrase replication capacity

26 October 2017

1 reference

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Whole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infection

26 October 2017

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Automating HIV drug resistance genotyping with RECall, a freely accessible sequence analysis tool

26 October 2017

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One protein to rule them all: modulation of cell surface receptors and molecules by HIV Nef.

26 October 2017

1 reference

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Effects of naturally-arising HIV Nef mutations on cytotoxic T lymphocyte recognition and Nef's functionality in primary macrophages.

26 October 2017

1 reference

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Mapping HIV-1 vaccine induced T-cell responses: bias towards less-conserved regions and potential impact on vaccine efficacy in the Step study

26 October 2017

1 reference

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HIV-1 replicative fitness in elite controllers

26 October 2017

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Qualitative features of the HIV-specific CD8+ T-cell response associated with immunologic control

26 October 2017

1 reference

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Mechanisms of HIV-1 Nef function and intracellular signaling

26 October 2017

1 reference

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The major genetic determinants of HIV-1 control affect HLA class I peptide presentation

26 October 2017

1 reference

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Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection

26 October 2017

1 reference

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Transmission of single HIV-1 genomes and dynamics of early immune escape revealed by ultra-deep sequencing

26 October 2017

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New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0

26 October 2017

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Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control

26 October 2017

1 reference

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Impaired replication capacity of acute/early viruses in persons who become HIV controllers

26 October 2017

1 reference

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HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins

26 October 2017

1 reference

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The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection

26 October 2017

1 reference

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Elite suppressor-derived HIV-1 envelope glycoproteins exhibit reduced entry efficiency and kinetics

26 October 2017

1 reference

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Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) response

26 October 2017

1 reference

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HLA-associated viral mutations are common in human immunodeficiency virus type 1 elite controllers

26 October 2017

1 reference

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NetMHCpan, a method for MHC class I binding prediction beyond humans

26 October 2017

1 reference

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HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136354

HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136354

Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136354

Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage

26 October 2017

1 reference

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Persistence of transmitted drug resistance among subjects with primary human immunodeficiency virus infection.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136354

HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down-regulation: analysis using short interfering RNA and knock-out mice.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136354

Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy.

26 October 2017

1 reference

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Nef-mediated enhancement of virion infectivity and stimulation of viral replication are fundamental properties of primate lentiviruses

26 October 2017

1 reference

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Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy

26 October 2017

1 reference

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Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A.

26 October 2017

1 reference

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NetMHCpan, a method for quantitative predictions of peptide binding to any HLA-A and -B locus protein of known sequence

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136354

A whole-genome association study of major determinants for host control of HIV-1

26 October 2017

1 reference

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Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection

26 October 2017

1 reference

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Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1

26 October 2017

1 reference

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HyPhy: hypothesis testing using phylogenies

26 October 2017

1 reference

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A Simple, Fast, and Accurate Algorithm to Estimate Large Phylogenies by Maximum Likelihood

26 October 2017

1 reference

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Down-modulation of mature major histocompatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136354

Proline 78 is crucial for human immunodeficiency virus type 1 Nef to down-regulate class I human leukocyte antigen

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136354

Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy.

26 October 2017

1 reference

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Structure--function relationships in HIV-1 Nef.

26 October 2017

1 reference

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HIV Nef-mediated cellular phenotypes are differentially expressed as a function of intracellular Nef concentrations

26 October 2017

1 reference

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Effect of a single amino acid change in MHC class I molecules on the rate of progression to AIDS

26 October 2017

1 reference

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Nef-induced major histocompatibility complex class I down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulation

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136354

Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136354

Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

26 October 2017

1 reference

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The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages

26 October 2017

1 reference

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Analysis of human immunodeficiency virus type 1 nef gene sequences present in vivo

26 October 2017

1 reference

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Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

26 October 2017

1 reference

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Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients

26 October 2017

1 reference

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Site-directed mutagenesis by overlap extension using the polymerase chain reaction

26 October 2017

1 reference

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Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

26 October 2017

1 reference

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Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene

26 October 2017

1 reference

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Reduced replication capacity of NL4-3 recombinant viruses encoding reverse transcriptase-integrase sequences from HIV-1 elite controllers

26 October 2017

1 reference

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Dynamic range of Nef functions in chronic HIV-1 infection

29 May 2018

1 reference

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HLA class I sequence-based typing using DNA recovered from frozen plasma.

17 August 2018

1 reference

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Long-term nonprogressive disease among untreated HIV-infected individuals: clinical implications of understanding immune control of HIV.

17 August 2018

1 reference

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Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection

17 August 2018

1 reference

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Effects of Human Leukocyte Antigen Class I Genetic Parameters on Clinical Outcomes and Survival after Initiation of Highly Active Antiretroviral Therapy

17 August 2018

1 reference

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CD8+ T-cell responses to different HIV proteins have discordant associations with viral load

1 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136354

Effect of long-term infection with nef-defective attenuated HIV type 1 on CD4+ and CD8+ T lymphocytes: increased CD45RO+CD4+ T lymphocytes and limited activation of CD8+ T lymphocytes

1 December 2018

1 reference

12 December 2020

Crippling HIV one mutation at a time

1 reference

12 December 2020

CTL-Mediated Selective Pressure Influences Dynamic Evolution and Pathogenic Functions of HIV-1 Nef

1 reference

12 December 2020

HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors

1 reference

12 December 2020

Identifiers

DOI

10.1128/JVI.01334-14

1 reference

release_dpidrpwxrbcdxpv5dnodzp3n3q

18 October 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/dpidrpwxrbcdxpv5dnodzp3n3q

24 November 2022

mapped directly with Wikidata item

1 reference

18 October 2017

1 reference