How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4 (Q27681494)

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Sang Yoon Park

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Juan S Bonifacino

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James H Hurley

The clathrin adaptor complexes as a paradigm for membrane-associated allostery

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language of work or name

English

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publication date

2014

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published in

eLife

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volume

3

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page(s)

e01754

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cites work

1 reference

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Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity

20 March 2017

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Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation

20 March 2017

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The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling

20 March 2017

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Nef-mediated clathrin-coated pit formation

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Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain

20 March 2017

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Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

20 March 2017

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Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

20 March 2017

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A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4

20 March 2017

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A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor

20 March 2017

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Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

7 April 2017

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20 March 2017

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20 March 2017

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The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase

20 March 2017

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Signals for sorting of transmembrane proteins to endosomes and lysosomes

20 March 2017

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Identification of a novel binding site between HIV type 1 Nef C-terminal flexible loop and AP2 required for Nef-mediated CD4 downregulation

7 April 2017

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Conservation and diversification of dileucine signal recognition by adaptor protein (AP) complex variants

29 September 2017

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Human immunodeficiency virus type 1 Nef protein targets CD4 to the multivesicular body pathway.

29 September 2017

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A basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complex

29 September 2017

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HIV-1 Nef: at the crossroads

29 September 2017

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A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2

29 September 2017

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29 September 2017

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The gamma/sigma1 and alpha/sigma2 hemicomplexes of clathrin adaptors AP-1 and AP-2 harbor the dileucine recognition site

29 September 2017

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Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor.

29 September 2017

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HIV Nef-mediated CD4 down-regulation is adaptor protein complex 2 dependent

29 September 2017

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The HIV-1 Nef protein as a target for antiretroviral therapy

29 September 2017

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CD4 down-modulation by human immunodeficiency virus type 1 Nef correlates with the efficiency of viral replication and with CD4(+) T-cell depletion in human lymphoid tissue ex vivo

29 September 2017

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Direct in vitro binding of full-length human immunodeficiency virus type 1 Nef protein to CD4 cytoplasmic domain

29 September 2017

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Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner

29 September 2017

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Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein

29 September 2017

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Refined solution structure and backbone dynamics of HIV-1 Nef.

29 September 2017

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29 September 2017

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The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. Mapping of the Nef binding surface by NMR.

29 September 2017

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Mutational analysis of HIV-1 Nef: identification of two mutants that are temperature-sensitive for CD4 downregulation

29 September 2017

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Effect of myristoylation on p27nef subcellular distribution and suppression of HIV-LTR transcription

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Dynamic interaction of HIV-1 Nef with the clathrin-mediated endocytic pathway at the plasma membrane.

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Crossref

https://api.crossref.org/works/10.7554%2FELIFE.01754

Partial "repair" of defective NEF genes in a long-term nonprogressor with human immunodeficiency virus type 1 infection

21 January 2018

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HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene product

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A modular polycistronic expression system for overexpressing protein complexes in Escherichia coli

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PubMed

https://pubmed.ncbi.nlm.nih.gov/24473078

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.7554/ELIFE.01754

1 reference

2579365

2579365

1 reference

1 reference

1 reference