A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction (Q42224585)

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scientific article published on 31 March 2012

Language	Label	Description	Also known as
English	A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction	scientific article published on 31 March 2012

Statements

scholarly article

1 reference

Europe PubMed Central

19 October 2017

A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction (English)

1 reference

Europe PubMed Central

19 October 2017

0 references

Nicoletta Bianchi

6

1 reference

Europe PubMed Central

19 October 2017

Stefano Rivella

10

1 reference

Europe PubMed Central

19 October 2017

Roberto Gambari

11

1 reference

Europe PubMed Central

19 October 2017

Francesca Salvatori

object named as

Francesca Salvatori

3

0 references

object named as

Laura Breda

2

0 references

Eleonora Brognara

object named as

Eleonora Brognara

7

0 references

Cristina Zuccato

object named as

Cristina Zuccato

1

0 references

Ilaria Lampronti

object named as

Ilaria Lampronti

8

0 references

Monica Borgatti

object named as

Monica Borgatti

9

0 references

author name string

Giulia Breveglieri

4

1 reference

Europe PubMed Central

19 October 2017

Sara Gardenghi

5

1 reference

Europe PubMed Central

19 October 2017

publication date

31 March 2012

1 reference

Europe PubMed Central

19 October 2017

Annals of Hematology

1 reference

Europe PubMed Central

19 October 2017

91

1 reference

Europe PubMed Central

19 October 2017

8

1 reference

Europe PubMed Central

19 October 2017

1201-1213

1 reference

Europe PubMed Central

19 October 2017

Gene therapy in thalassemia and hemoglobinopathies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

Therapeutic levels of fetal hemoglobin in erythroid progeny of β-thalassemic CD34+ cells after lentiviral vector-mediated gene transfer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

A preclinical approach for gene therapy of beta-thalassemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

Hydroxyurea-induced hematological response in transfusion-independent beta-thalassemia intermedia: case series and review of literature

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

A spectrum of gene regulatory phenomena at mammalian beta-globin gene loci

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

Production of beta-globin and adult hemoglobin following G418 treatment of erythroid precursor cells from homozygous beta(0)39 thalassemia patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

Increase in gamma-globin mRNA content in human erythroid cells treated with angelicin analogs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

Progress and prospects: gene therapy for inherited immunodeficiencies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

Bergamot (Citrus bergamia Risso) fruit extracts as γ-globin gene expression inducers: phytochemical and functional perspectives.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

Discovering the genetics underlying foetal haemoglobin production in adults.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

Controlling alpha-globin: a review of alpha-globin expression and its impact on beta-thalassemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

Medicinal chemistry of fetal hemoglobin inducers for treatment of beta-thalassemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

Regulation of human fetal hemoglobin: new players, new complexities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

Developmental regulation of the beta-globin gene locus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

Control of globin gene expression during development and erythroid differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

Genetic insights into the clinical diversity of beta thalassaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

Mithramycin SK, A Novel Antitumor Drug with Improved Therapeutic Index, Mithramycin SA, and Demycarosyl-mithramycin SK: Three New Products Generated in the Mithramycin Producer Streptomyces argillaceus through Combinatorial Biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

Screening and genetic diagnosis of haemoglobin disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

Therapeutic globin gene delivery using lentiviral vectors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

Beta-thalassaemia prototype of a single gene disorder with multiple phenotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

Thalassemia and abnormal hemoglobin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

Pathophysiology of thalassemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

Clinical management of beta-thalassemia major

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

Pathophysiology of alpha- and beta-thalassemia: therapeutic implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human beta-globin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

The cHS4 insulator increases the probability of retroviral expression at random chromosomal integration sites.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

Butyrate in the treatment of sickle cell disease and beta-thalassemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

26 October 2017

Gene therapy. Beta-thalassemia treatment succeeds, with a caveat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

29 May 2018

A phase I/II clinical trial of beta-globin gene therapy for beta-thalassemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

29 May 2018

Fetal gene reactivation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

29 May 2018

Elimination of transfusions through induction of fetal hemoglobin synthesis in Cooley's anemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

29 May 2018

Fetal hemoglobin levels and morbidity in untransfused patients with β-thalassemia intermedia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

17 August 2018

Effect of hydroxyurea on the transfusion requirements in patients with severe HbE-beta-thalassaemia: a genotypic and phenotypic study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

17 August 2018

Foetal haemoglobin inducers and thalassaemia: novel achievements

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

17 August 2018

Gene therapy for homozygous beta-thalassemia. Is it a reality?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

17 August 2018

Response to hydroxyurea in beta thalassemia major and intermedia: experience in western India.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

17 August 2018

Development of K562 cell clones expressing beta-globin mRNA carrying the beta039 thalassaemia mutation for the screening of correctors of stop-codon mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

17 August 2018

The HBS1L-MYB intergenic region on chromosome 6q23 is a quantitative trait locus controlling fetal haemoglobin level in carriers of beta-thalassaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

17 August 2018

siRNA-mediated reduction of alpha-globin results in phenotypic improvements in beta-thalassemic cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

17 August 2018

Restoration of the balanced alpha/beta-globin gene expression in beta654-thalassemia mice using combined RNAi and antisense RNA approach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

17 August 2018

Everolimus is a potent inducer of erythroid differentiation and gamma-globin gene expression in human erythroid cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

17 August 2018

Effects of rapamycin on accumulation of alpha-, beta- and gamma-globin mRNAs in erythroid precursor cells from beta-thalassaemia patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

17 August 2018

Accumulation of gamma-globin mRNA in human erythroid cells treated with angelicin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

17 August 2018

Mithramycin induces fetal hemoglobin production in normal and thalassemic human erythroid precursor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

17 August 2018

A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human beta-globin gene transfer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

17 August 2018

A Novel Frameshift Mutation (+A) at Codon 18 of the β-Globin Gene Associated with High Persistence of Fetal Hemoglobin Phenotype and δβ-Thalassemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3389244

30 September 2018

Globin Lentiviral Vector Insertions Can Perturb the Expression of Endogenous Genes in β-thalassemic Hematopoietic Cells

2 references

https://api.crossref.org/works/10.1007%2FS00277-012-1430-5

21 January 2018

https://pubmed.ncbi.nlm.nih.gov/22460946

12 December 2020

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Enhanced fetal hemoglobin production by phenylacetate and 4-phenylbutyrate in erythroid precursors derived from normal donors and patients with sickle cell anemia and beta-thalassemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proliferation and maturation of human erythroid progenitors in liquid culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460946

12 December 2020

based on heuristic

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Two-phase liquid culture system models normal human adult erythropoiesis at the molecular level

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460946

12 December 2020

based on heuristic

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Human leukemia K-562 cells: induction of erythroid differentiation by 5-azacytidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460946

12 December 2020

based on heuristic

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Successful treatment of murine beta-thalassemia intermedia by transfer of the human beta-globin gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460946

12 December 2020

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Combination therapy of erythropoietin, hydroxyurea, and clotrimazole in a beta thalassemic mouse: a model for human therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22460946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00277-012-1430-5

1 reference

Europe PubMed Central

19 October 2017

1 reference

Europe PubMed Central

19 October 2017

1 reference

Europe PubMed Central

19 October 2017

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