Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics (Q42260847)

19 October 2017

Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics (English)

1 reference

19 October 2017

1 reference

Jyh-Chang Jean

7

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Darrell N Kotton

object named as

Darrell N Kotton

10

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Gordon M. Keller

object named as

Gordon Keller

11

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author name string

Cecile Terrenoire

1

1 reference

19 October 2017

Kai Wang

2

1 reference

19 October 2017

Kelvin W Chan Tung

3

1 reference

19 October 2017

Wendy K Chung

4

1 reference

19 October 2017

Robert H Pass

5

1 reference

19 October 2017

Jonathan T Lu

6

1 reference

19 October 2017

Amel Omari

8

1 reference

19 October 2017

Kevin J Sampson

9

1 reference

19 October 2017

Robert S Kass

12

1 reference

19 October 2017

language of work or name

1 reference

1 January 2013

1 reference

The Journal of General Physiology

19 October 2017

1 reference

19 October 2017

141

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19 October 2017

1

1 reference

19 October 2017

61-72

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Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel

19 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

Cardiomyocytes generated from CPVTD307H patients are arrhythmogenic in response to β-adrenergic stimulation

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

Biophysical properties of slow potassium channels in human embryonic stem cell derived cardiomyocytes implicate subunit stoichiometry

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

Modelling the long QT syndrome with induced pluripotent stem cells

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

Patient-specific induced pluripotent stem-cell models for long-QT syndrome

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

Long QT syndrome with compound mutations is associated with a more severe phenotype: a Japanese multicenter study.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

Long QT syndrome due to a novel mutation in SCN5A: treatment with ICD placement at 1 month and left cardiac sympathetic denervation at 3 months of age.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

Sodium channel mutations and arrhythmias

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

Induced pluripotent stem cell generation using a single lentiviral stem cell cassette

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

Cardiac potassium channel dysfunction in sudden infant death syndrome

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

A novel and lethal de novo LQT-3 mutation in a newborn with distinct molecular pharmacology and therapeutic response

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

Mutation-specific pharmacology of the long QT syndrome.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

Long QT syndrome: from channels to cardiac arrhythmias

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

Structural determinants for high-affinity block of hERG potassium channels.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

Functional characterization of the common amino acid 897 polymorphism of the cardiac potassium channel KCNH2 (HERG).

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

Common molecular determinants of flecainide and lidocaine block of heart Na+ channels: evidence from experiments with neutral and quaternary flecainide analogues

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndrome

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

A structural basis for drug-induced long QT syndrome

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

Lidocaine block of LQT-3 mutant human Na+ channels

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate. Implications for gene-specific therapy.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

KCNH2-K897T is a genetic modifier of latent congenital long-QT syndrome

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

Modelling long QT syndrome with iPS cells: be still, my beating heart ...

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

A computational model of Purkinje fibre single cell electrophysiology: implications for the long QT syndrome.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

A novel LQT-3 mutation disrupts an inactivation gate complex with distinct rate-dependent phenotypic consequences

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

Long QT syndrome in adults.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

Autonomic control of cardiac action potentials: role of potassium channel kinetics in response to sympathetic stimulation.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

Mechanism of spontaneous excitability in human embryonic stem cell derived cardiomyocytes

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

Compound mutations: a common cause of severe long-QT syndrome

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

Molecular and functional characterization of common polymorphisms in HERG (KCNH2) potassium channels

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

A model for human ventricular tissue

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3536519

A common polymorphism in KCNH2 (HERG) hastens cardiac repolarization

17 August 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.201210899

The non-synonymous coding IKr-channel variant KCNH2-K897T is associated with atrial fibrillation: results from a systematic candidate gene-based analysis of KCNH2 (HERG)

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.201210899

The Unstoppable Attraction for Induced Pluripotent Stem Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.201210899

Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.201210899

Induced pluripotent stem cells in long-QT syndrome

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23277474

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

An electrifying iPSC disease model: long QT syndrome type 2 and heart cells in a dish

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23277474

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Gating Properties of SCN5A Mutations and the Response to Mexiletine in Long-QT Syndrome Type 3 Patients

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23277474

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1085/JGP.201210899

1 reference

19 October 2017

1 reference

19 October 2017

PubMed publication ID

23277474

1 reference