Hnf1alpha (MODY3) controls tissue-specific transcriptional programs and exerts opposed effects on cell growth in pancreatic islets and liver. (Q42267668)

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scientific article published on 16 March 2009

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English	Hnf1alpha (MODY3) controls tissue-specific transcriptional programs and exerts opposed effects on cell growth in pancreatic islets and liver.	scientific article published on 16 March 2009

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23 January 2020

Hnf1alpha (MODY3) controls tissue-specific transcriptional programs and exerts opposed effects on cell growth in pancreatic islets and liver (English)

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23 January 2020

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Joan Marc Servitja Duque

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Roderic Guigó i Serra

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Roderic Guigó

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23 January 2020

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Miguel Pignatelli

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Miguel Angel Maestro

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Carina Cardalda

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Sylvia F Boj

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23 January 2020

Amàlia Lafuente

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Lauro Sumoy

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16 March 2009

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23 January 2020

Molecular and Cellular Biology

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2945-2959

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23 January 2020

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22 June 2022

https://europepmc.org/article/PMC/2682018

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Functional targets of the monogenic diabetes transcription factors HNF-1alpha and HNF-4alpha are highly conserved between mice and humans

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A conditional model reveals that induction of hepatocyte nuclear factor-1alpha in Hnf1alpha-null mutant beta-cells can activate silenced genes postnatally, whereas overexpression is deleterious

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The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation

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Transthyretin constitutes a functional component in pancreatic beta-cell stimulus-secretion coupling

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The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion

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Transcriptional networks controlling pancreatic development and beta cell function.

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Glucose and insulin treatment of insulinoma cells results in transcriptional regulation of a common set of genes

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Interaction of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) with glucokinase activates glucose phosphorylation and glucose metabolism in insulin-producing cells

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A transcriptional network in polycystic kidney disease

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Control of pancreas and liver gene expression by HNF transcription factors

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An expression profile of human pancreatic islet mRNAs by Serial Analysis of Gene Expression (SAGE).

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Genetic cause of hyperglycaemia and response to treatment in diabetes

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Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas

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Functions of HNF1 family members in differentiation of the visceral endoderm cell lineage

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Gene expression cascades in pancreatic development

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17 August 2018

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17 August 2018

Hepatic expression of cytochrome P450s in hepatocyte nuclear factor 1-alpha (HNF1α)-deficient mice

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17 August 2018

Overexpression of dominant-negative mutant hepatocyte nuclear fctor-1 alpha in pancreatic beta-cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced beta-cell proliferation, and diabetes.

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17 August 2018

Beta-cell-targeted expression of a dominant-negative hepatocyte nuclear factor-1 alpha induces a maturity-onset diabetes of the young (MODY)3-like phenotype in transgenic mice.

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17 August 2018

Two variants on chromosome 17 confer prostate cancer risk and the one in TCF2 protects against type 2 diabetes

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1 December 2018

Signals derived from glucose metabolism are required for glucose regulation of pancreatic islet GLUT2 mRNA and protein

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12 December 2020

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A liver-specific factor essential for albumin transcription differs between differentiated and dedifferentiated rat hepatoma cells

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12 December 2020

based on heuristic

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Expression of HNF-4alpha (MODY1), HNF-1beta (MODY5), and HNF-1alpha (MODY3) proteins in the developing mouse pancreas

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12 December 2020

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https://pubmed.ncbi.nlm.nih.gov/19289501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.01389-08

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19289501%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19289501%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19289501%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

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