Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal (Q42509225)

5 November 2017

Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal (English)

1 reference

single cell transcriptomics

5 November 2017

1 reference

A curated database reveals trends in single-cell transcriptomics

https://www.nxn.se/single-cell-studies/data.tsv

Lgr5+ intestinal stem-cell

7 February 2021

1 reference

based on heuristic

inferred from title

stem cell self-renewal

1 reference

29

Tarjei S Mikkelsen

1 reference

5 November 2017

4

Grace X Y Zheng

1 reference

5 November 2017

6

Vincent C Luca

1 reference

5 November 2017

31

Calvin J Kuo

1 reference

5 November 2017

22

Solongo B Ziraldo

1 reference

5 November 2017

26

Michael P Snyder

1 reference

5 November 2017

27

Irving L Weissman

1 reference

5 November 2017

Kelley S Yan

1

1 reference

5 November 2017

Claudia Y Janda

2

1 reference

5 November 2017

Junlei Chang

3

1 reference

5 November 2017

Kathryn A Larkin

5

1 reference

5 November 2017

Luis A Chia

7

1 reference

5 November 2017

Amanda T Mah

8

1 reference

5 November 2017

Arnold Han

9

1 reference

5 November 2017

Jessica M Terry

10

1 reference

5 November 2017

Akifumi Ootani

11

1 reference

5 November 2017

Kelly Roelf

12

1 reference

5 November 2017

Mark Lee

13

1 reference

5 November 2017

Jenny Yuan

14

1 reference

5 November 2017

Xiao Li

15

1 reference

5 November 2017

Christopher R Bolen

16

1 reference

5 November 2017

Julie Wilhelmy

17

1 reference

5 November 2017

Paige S Davies

18

1 reference

5 November 2017

Hiroo Ueno

19

1 reference

5 November 2017

Richard J von Furstenberg

20

1 reference

5 November 2017

Phillip Belgrader

21

1 reference

5 November 2017

Heather Ordonez

23

1 reference

5 November 2017

Susan J Henning

24

1 reference

5 November 2017

Melissa H Wong

25

1 reference

5 November 2017

Aaron J Hsueh

28

1 reference

5 November 2017

K Christopher Garcia

30

1 reference

5 November 2017

language of work or name

English

0 references

publication date

3 May 2017

1 reference

external data available at URL

5 November 2017

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE92377

1 reference

A curated database reveals trends in single-cell transcriptomics

https://www.nxn.se/single-cell-studies/data.tsv

7 February 2021

1 reference

5 November 2017

545

1 reference

5 November 2017

238-242

1 reference

5 November 2017

7653

1 reference

describes a project that uses

5 November 2017

small intestine

1 reference

A curated database reveals trends in single-cell transcriptomics

7 February 2021

https://www.nxn.se/single-cell-studies/data.tsv

exact match

https://scigraph.springernature.com/pub.10.1038/nature22313

0 references

cites work

Massively parallel digital transcriptional profiling of single cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Single-cell messenger RNA sequencing reveals rare intestinal cell types

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

HTSeq--a Python framework to work with high-throughput sequencing data

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

The intestinal crypt, a prototype stem cell compartment

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Shrinkage estimation of dispersion in Negative Binomial models for RNA-seq experiments with small sample size

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Structural basis of Wnt recognition by Frizzled

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Characterization of the intestinal cancer stem cell marker CD166 in the human and mouse gastrointestinal tract

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

TopHat: discovering splice junctions with RNA-Seq

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Identification of stem cells in small intestine and colon by marker gene Lgr5

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Isolating and engineering human antibodies using yeast surface display

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Mitogenic influence of human R-spondin1 on the intestinal epithelium

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Canonical Wnt signals are essential for homeostasis of the intestinal epithelium

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Wnt proteins are lipid-modified and can act as stem cell growth factors

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Intestinal stem cell replacement follows a pattern of neutral drift

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5641471

Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts

16 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE22313

21 January 2018

Identifiers

DOI

10.1038/NATURE22313

1 reference

Dimensions Publication ID

5 November 2017

0 references

1 reference

5 November 2017

1 reference