Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin (Q24338954)

2

1 reference

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3 June 2020

author name string

Yang Xie

1

1 reference

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3 June 2020

Olga Charlat

3

1 reference

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3 June 2020

Melissa Ramones

4

1 reference

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3 June 2020

Susanne Swalley

5

1 reference

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3 June 2020

Xiaomo Jiang

6

1 reference

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3 June 2020

Daniel Rivera

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24165923%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

William Tschantz

8

1 reference

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3 June 2020

Bo Lu

9

1 reference

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3 June 2020

Lisa Quinn

10

1 reference

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3 June 2020

Chris Dimitri

11

1 reference

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3 June 2020

Jefferson Parker

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24165923%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Doug Jeffery

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24165923%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Sheri K Wilcox

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24165923%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Mike Watrobka

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24165923%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Peter LeMotte

16

1 reference

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3 June 2020

Brian Granda

17

1 reference

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3 June 2020

Jeffrey A Porter

18

1 reference

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3 June 2020

Vic E Myer

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24165923%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Andreas Loew

20

1 reference

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3 June 2020

Feng Cong

21

1 reference

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3 June 2020

language of work or name

English

0 references

publication date

December 2013

0 references

published in

EMBO Reports

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24165923%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

volume

14

1 reference

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3 June 2020

issue

12

1 reference

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3 June 2020

page(s)

1120-1126

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24165923%20AND%20SRC:MED&resulttype=core&format=json

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

3 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981092

R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981092

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981092

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981092

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981092

Wnt/beta-catenin signaling: components, mechanisms, and diseases

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981092

A transposon-based genetic screen in mice identifies genes altered in colorectal cancer

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981092

R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981092

Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981092

Wnt/β-catenin signaling and disease

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981092

The R-spondin protein family

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981092

Crystal Structures of Lgr4 and Its Complex with R-Spondin1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981092

Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981092

Structural basis for R-spondin recognition by LGR4/5/6 receptors

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981092

The structural basis of R-spondin recognition by LGR5 and RNF43

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981092

Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981092

Recurrent R-spondin fusions in colon cancer

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981092

LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981092

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981092

MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981092

The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981092

Mitogenic influence of human R-spondin1 on the intestinal epithelium

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981092

R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3981092

R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling

27 September 2017

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FEMBOR.2013.167

Rspo3 binds syndecan 4 and induces Wnt/PCP signaling via clathrin-mediated endocytosis to promote morphogenesis

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24165923

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/EMBOR.2013.167

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24165923%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24165923%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

PubMed publication ID

24165923

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24165923%20AND%20SRC:MED&resulttype=core&format=json