Amino acid- and lipid-induced insulin resistance in rat heart: molecular mechanisms (Q42521099)

1 November 2017

Amino acid- and lipid-induced insulin resistance in rat heart: molecular mechanisms (English)

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1 November 2017

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Ileana Terruzzi

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Paola Maroni

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Paola Maroni

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Michele Samaja

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Michele Samaja

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Livio Luzi

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Livio Luzi

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author name string

Sonia Allibardi

2

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1 November 2017

Paola Bendinelli

3

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1 November 2017

Roberta Piccoletti

5

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1 November 2017

Flavio Vesco

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1 November 2017

1 April 2002

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Molecular and Cellular Endocrinology

1 November 2017

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1 November 2017

190

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1 November 2017

135-145

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1 November 2017

1-2

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Mechanism of activation and function of protein kinase B.

1 November 2017

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Evidence That 3-Phosphoinositide-dependent Protein Kinase-1 Mediates Phosphorylation of p70 S6 Kinasein Vivoat Thr-412 as well as Thr-252

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Effects of fat on insulin-stimulated carbohydrate metabolism in normal men

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Mechanisms of fatty acid-induced inhibition of glucose uptake

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Not all Shc's roads lead to Ras

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Inhibition of glycogen synthase kinase-3 by insulin in cultured human skeletal muscle myoblasts

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Effect of insulin and plasma amino acid concentrations on leucine metabolism in man. Role of substrate availability on estimates of whole body protein synthesis

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated prote

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Functional interactions of phosphatidylinositol 3-kinase with GTPase-activating protein in 3T3-L1 adipocytes.

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Short-term regulation of insulin-mediated glucose utilization in four-day fasted human volunteers: role of amino acid availability.

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Calculation of substrate oxidation rates in vivo from gaseous exchange.

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Glucocorticoid regulation of insulin receptor and substrate IRS-1 tyrosine phosphorylation in rat skeletal muscle in vivo

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Oxidation of amino acids by diaphragms from fed and fasted rats

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Akt signaling: linking membrane events to life and death decisions

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

From receptor to transporter: insulin signalling to glucose transport.

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Insulin action in cultured human myoblasts: contribution of different signalling pathways to regulation of glycogen synthesis.

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Molecular cloning and characterization of an insulin-regulatable glucose transporter

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Translational and pretranslational regulation of protein synthesis by amino acid availability in primary cultures of rat hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Myocardial Lipid and Carbohydrate Metabolism in Healthy, Fasting Men at Rest: Studies During Continuous Infusion of 3H‐Palmitate

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Wortmannin inhibits the action of insulin but not that of okadaic acid in skeletal muscle: comparison with fat cells

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Amino acids regulate skeletal muscle PHAS-I and p70 S6-kinase phosphorylation independently of insulin

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Multiple signalling pathways involved in the stimulation of fatty acid and glycogen synthesis by insulin in rat epididymal fat cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and beta-adrenergic agonists in rat epididymal fat cells. Activation of protein kinase B by wortmannin-sensitive and -insensitive mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Phorbol esters stimulate phosphatidylinositol 3,4,5-trisphosphate production in 3T3-L1 adipocytes: implications for stimulation of glucose transport

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Bidirectional modulation of insulin action by amino acids

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Signalling pathways involved in the stimulation of glycogen synthesis by insulin in rat hepatocytes

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Rapid stimulation of mitogen-activated protein kinase of rat liver by prolactin

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Involvement of Shc in insulin- and epidermal growth factor-induced activation of p21ras

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Phosphorylation and activation of p70s6k by PDK1

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Identification of enhanced serine kinase activity in insulin resistance

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years.

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Mechanisms modifying glucose oxidation in diabetes mellitus

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Mechanism of free fatty acid-induced insulin resistance in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Acute effects of glucose-insulin-potassium infusion on myocardial substrates, coronary blood flow and oxygen consumption in man

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Ras-independent and wortmannin-sensitive activation of glycogen synthase by insulin in Chinese hamster ovary cells

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

The role of phosphoinositide 3-kinase in insulin signalling

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Translocation of the glucose transporter GLUT4 in cardiac myocytes of the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

The role of substrates in the regulation of protein metabolism.

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Interrelationship between lactate and cardiac fatty acid metabolism

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Amino acid availability regulates p70 S6 kinase and multiple translation factors

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Activation of mRNA translation in rat cardiac myocytes by insulin involves multiple rapamycin-sensitive steps

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B.

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

The IRS-signalling system: a network of docking proteins that mediate insulin action

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Signalling through the insulin receptor

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Upstream mechanisms of glycogen synthase activation by insulin and insulin-like growth factor-I. Glycogen synthase activation is antagonized by wortmannin or LY294002 but not by rapamycin or by inhibiting p21ras

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

Role of insulin and insulin receptor in learning and memory

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https://api.crossref.org/works/10.1016%2FS0303-7207%2802%2900005-9

7 January 2021

10.1016/S0303-7207(02)00005-9

Identifiers

DOI

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1 November 2017

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