p53- and p21-independent apoptosis of squamous cell carcinoma cells induced by 5-fluorouracil and radiation (Q42536360)

1 November 2017

title

p53- and p21-independent apoptosis of squamous cell carcinoma cells induced by 5-fluorouracil and radiation (English)

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1 November 2017

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Yoneda K

1

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1 November 2017

Yamamoto T

series ordinal

2

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1 November 2017

Osaki T

series ordinal

3

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1 November 2017

language of work or name

English

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publication date

1 November 1998

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1 November 2017

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1 November 2017

volume

34

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1 November 2017

issue

6

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1 November 2017

page(s)

529-537

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The action of 5-fluorouracil on human HT29 colon cancer cells grown in SCID mice: mitosis, apoptosis and cell differentiation

1 November 2017

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p21 is a universal inhibitor of cyclin kinases

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

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Wild-type human p53 transactivates the human proliferating cell nuclear antigen promoter

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Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase

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The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2

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p21-containing cyclin kinases exist in both active and inactive states

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Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization.

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7 January 2021

10.1016/S1368-8375(98)00036-0

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DOI

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release_g3qq7otpofcrxoevefs3o2vwqa

1 November 2017

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24 November 2022

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