The cyclophilin inhibitor Debio 025 normalizes mitochondrial function, muscle apoptosis and ultrastructural defects in Col6a1-/- myopathic mice. (Q42545449)

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scientific article published on 10 June 2009

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English	The cyclophilin inhibitor Debio 025 normalizes mitochondrial function, muscle apoptosis and ultrastructural defects in Col6a1-/- myopathic mice.	scientific article published on 10 June 2009

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31 January 2020

The cyclophilin inhibitor Debio 025 normalizes mitochondrial function, muscle apoptosis and ultrastructural defects in Col6a1-/- myopathic mice (English)

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31 January 2020

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Luciano Merlini

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Paola Braghetta

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T Tiepolo

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A Angelin

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E Palma

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P Sabatelli

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L Nicolosi

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F Finetti

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G Vuagniaux

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J-M Dumont

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C T Baldari

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P Bonaldo

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10 June 2009

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31 January 2020

British Journal of Pharmacology

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1045-1052

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6

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31 January 2020

Therapy of collagen VI-related myopathies (Bethlem and Ullrich).

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28 May 2018

Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria

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28 May 2018

Investigation of Debio 025, a cyclophilin inhibitor, in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy

1 reference

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28 May 2018

Cyclosporin A corrects mitochondrial dysfunction and muscle apoptosis in patients with collagen VI myopathies

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28 May 2018

Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy

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28 May 2018

Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent

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28 May 2018

Cyclophilin inhibitors in hepatitis C viral infection

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28 May 2018

Preferential chemotaxis of activated human CD4+ T cells by extracellular cyclophilin A

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28 May 2018

The mitochondrial permeability transition pore and its involvement in cell death and in disease pathogenesis

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28 May 2018

Mitochondrial dysfunction in the pathogenesis of Ullrich congenital muscular dystrophy and prospective therapy with cyclosporins

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28 May 2018

Cyclophilin, TRIM5, and innate immunity to HIV-1

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28 May 2018

The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro

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28 May 2018

Peptidyl-prolyl cis-trans isomerases (immunophilins) and their roles in parasite biochemistry, host-parasite interaction and antiparasitic drug action

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28 May 2018

Naturally occurring capsid substitutions render HIV-1 cyclophilin A independent in human cells and TRIM-cyclophilin-resistant in Owl monkey cells

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28 May 2018

The cyclophilins

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28 May 2018

Cyclophilin A may contribute to the inflammatory processes in rheumatoid arthritis through induction of matrix degrading enzymes and inflammatory cytokines from macrophages

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28 May 2018

Extracellular cyclophilins contribute to the regulation of inflammatory responses

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28 May 2018

Roles of cyclophilins in cancers and other organ systems

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28 May 2018

The nonimmunosuppressive cyclosporin analogs NIM811 and UNIL025 display nanomolar potencies on permeability transition in brain-derived mitochondria.

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28 May 2018

Cyclophilin A as a novel biphasic mediator of endothelial activation and dysfunction.

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28 May 2018

Cyclophilin D as a drug target

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Identification and characterization of a novel nuclear factor of activated T-cells-1 isoform expressed in mouse brain

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28 May 2018

Regulation of the permeability transition pore in skeletal muscle mitochondria. Modulation By electron flow through the respiratory chain complex i.

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28 May 2018

cDNA cloning of rat mitochondrial cyclophilin.

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28 May 2018

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

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28 May 2018

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

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28 May 2018

Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases, and blockade of T cell signal transduction

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28 May 2018

Purification and N-terminal sequencing of peptidyl-prolyl cis-trans-isomerase from rat liver mitochondrial matrix reveals the existence of a distinct mitochondrial cyclophilin

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28 May 2018

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

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28 May 2018

Active site mutants of human cyclophilin A separate peptidyl-prolyl isomerase activity from cyclosporin A binding and calcineurin inhibition

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28 May 2018

Effects of the new anti-lymphocytic peptide cyclosporin A in animals

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28 May 2018

The cyclophilin inhibitor Debio 025 combined with PEG IFNalpha2a significantly reduces viral load in treatment-naïve hepatitis C patients.

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16 August 2018

Genetic ablation of cyclophilin D rescues mitochondrial defects and prevents muscle apoptosis in collagen VI myopathic mice

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16 August 2018

The cyclophilin inhibitor Debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus.

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16 August 2018

Evaluation of a cyclophilin inhibitor in hepatitis C virus-infected chimeric mice in vivo

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16 August 2018

Cyclophilin C-associated protein is up-regulated during wound healing

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16 August 2018

Cyclophilin A is a proinflammatory cytokine that activates endothelial cells

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The Helicobacter pylori vacuolating toxin inhibits T cell activation by two independent mechanisms.

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16 August 2018

Mitochondrial dysfunction and apoptosis in myopathic mice with collagen VI deficiency.

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16 August 2018

Inhibition of the mitochondrial permeability transition by the nonimmunosuppressive cyclosporin derivative NIM811.

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16 August 2018

Bupivacaine myotoxicity is mediated by mitochondria

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16 August 2018

Influence of cyclosporine A on contractile function, calcium handling, and energetics in isolated human and rabbit myocardium.

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16 August 2018

Collagen VI deficiency induces early onset myopathy in the mouse: an animal model for Bethlem myopathy.

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16 August 2018

Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, and cyclosporin A-sensitive channel.

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16 August 2018

On the effects of paraquat on isolated mitochondria. Evidence that paraquat causes opening of the cyclosporin A-sensitive permeability transition pore synergistically with nitric oxide.

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A Ubiquinone-binding Site Regulates the Mitochondrial Permeability Transition Pore

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12 December 2020

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Inhibition of mitochondrial permeability transition improves functional recovery and reduces mortality following acute myocardial infarction in mice

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https://pubmed.ncbi.nlm.nih.gov/19519726

12 December 2020

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10.1111/J.1476-5381.2009.00316.X

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31 January 2020

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31 January 2020

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31 January 2020

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