Low density lipoprotein receptor (Q425649)

Six-bladed beta-propeller, TolB-like

1 reference

Growth factor receptor cysteine-rich domain superfamily

1 reference

EGF-like calcium-binding domain, protein family

1 reference

EGF-like domain, protein family

1 reference

Low-density lipoprotein (LDL) receptor class A, conserved site, protein family

1 reference

EGF-like, conserved site, protein family

1 reference

Low-density lipoprotein (LDL) receptor class A repeat, protein family

1 reference

LDLR class B repeat, protein family

1 reference

EGF-like calcium-binding, conserved site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

clathrin heavy chain binding

1 reference

8 April 2019

The mu2 subunit of the clathrin adaptor AP-2 binds to FDNPVY and YppØ sorting signals at distinct sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

TAS

virus receptor activity

1 reference

8 April 2019

13 references

9 May 2017

Reelin is a ligand for lipoprotein receptors

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01130

8 April 2019

The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

MMP-2 inhibits PCSK9-induced degradation of the LDL receptor in Hepa1-c1c7 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

LDL receptor/lipoprotein recognition: endosomal weakening of ApoB and ApoE binding to the convex face of the LR5 repeat

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

Molecular basis for LDL receptor recognition by PCSK9

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

Mode of interaction between beta2GPI and lipoprotein receptors suggests mutually exclusive binding of beta2GPI to the receptors and anionic phospholipids

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

Atomic structure of the autosomal recessive hypercholesterolemia phosphotyrosine-binding domain in complex with the LDL-receptor tail

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

Reelin is a ligand for lipoprotein receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

identical protein binding

IPI

1 reference

8 April 2019

The closed conformation of the LDL receptor is destabilized by the low Ca(++) concentration but favored by the high Mg(++) concentration in the endosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

low-density lipoprotein particle receptor activity

IPI

7 references

8 April 2019

Analysis of a recycling-impaired mutant of low density lipoprotein receptor in familial hypercholesterolemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

The LDL receptor locus in familial hypercholesterolemia: Multiple mutations disrupt transport and processing of a membrane receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

integral component of membrane

IC

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

clathrin-coated endocytic vesicle membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

1 reference

8 April 2019

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

3 references

integral component of plasma membrane

1 reference

8 April 2019

Domain map of the LDL receptor: Sequence homology with the epidermal growth factor precursor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

low-density lipoprotein particle

IDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

external side of plasma membrane

TAS

1 reference

8 April 2019

The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01130

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

endolysosome membrane

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

intracellular anatomical structure

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01130&geneProductId=UniProtKB:P01130

somatodendritic compartment

ISS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

steroid metabolic process

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

4 references

8 April 2019

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

The LDL receptor locus in familial hypercholesterolemia: Multiple mutations disrupt transport and processing of a membrane receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

lipoprotein catabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

intestinal cholesterol absorption

1 reference

8 April 2019

Genetic causes of familial hypercholesterolaemia in patients in the UK: relation to plasma lipid levels and coronary heart disease risk

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01130

viral entry into host cell

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

Genetic causes of familial hypercholesterolaemia in patients in the UK: relation to plasma lipid levels and coronary heart disease risk

cholesterol homeostasis

3 references

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01130

9 May 2017

The LDL receptor locus in familial hypercholesterolemia: Multiple mutations disrupt transport and processing of a membrane receptor

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01130

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01130

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

positive regulation of gene expression

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

positive regulation of inflammatory response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

lipoprotein metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

cellular response to fatty acid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

negative regulation of gene expression

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

membrane organization

1 reference

8 April 2019

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

The LDL receptor locus in familial hypercholesterolemia: Multiple mutations disrupt transport and processing of a membrane receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

cellular response to low-density lipoprotein particle stimulus

1 reference

8 April 2019

The LDL receptor locus in familial hypercholesterolemia: Multiple mutations disrupt transport and processing of a membrane receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

receptor-mediated endocytosis involved in cholesterol transport

IMP

1 reference

8 April 2019

The LDL receptor locus in familial hypercholesterolemia: Multiple mutations disrupt transport and processing of a membrane receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

chylomicron remnant clearance

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

low-density lipoprotein particle clearance

TAS

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

The LDL receptor locus in familial hypercholesterolemia: Multiple mutations disrupt transport and processing of a membrane receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

Genetic causes of familial hypercholesterolaemia in patients in the UK: relation to plasma lipid levels and coronary heart disease risk

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

receptor-mediated endocytosis

3 references

cholesterol transport

3 references

8 April 2019

Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

Genetic causes of familial hypercholesterolaemia in patients in the UK: relation to plasma lipid levels and coronary heart disease risk

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

plasma lipoprotein particle clearance

3 references

8 April 2019

Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

high-density lipoprotein particle clearance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance

cholesterol homeostasis

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

The LDL receptor locus in familial hypercholesterolemia: Multiple mutations disrupt transport and processing of a membrane receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

Genetic causes of familial hypercholesterolaemia in patients in the UK: relation to plasma lipid levels and coronary heart disease risk

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

regulation of cholesterol metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130

http://purl.uniprot.org/uniprot/P01130

Gene Atlas image

PBB GE LDLR 202068 s at fs.png
732 × 530; 11 KB

0 references

exact match

1 reference

EGF-type aspartate/asparagine hydroxylation site

Identifiers.org

has part(s)

1 reference

EGF-like calcium-binding, conserved site

1 reference

Low-density lipoprotein (LDL) receptor class A, conserved site

1 reference

EGF-like, conserved site

1 reference

low-density lipoprotein (LDL) receptor class A repeat

1 reference

EGF-like calcium-binding domain

1 reference

EGF-like domain

1 reference

LDLR class B repeat

1 reference

https://docs.openalex.org/download-snapshot/snapshot-data-format

Identifiers

MeSH descriptor ID

D011973

subject named as

Receptors, LDL

0 references

MeSH tree code

D12.776.543.750.710.450

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

28 October 2013

Microsoft Academic ID

0 references

0 references

1 reference

26 January 2022

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference