The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR (Q24303965)

Proprotein convertase subtilisin/kexin type 9

GOA release 2020-03-11

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GOA release 2020-03-11

Annik Prat

9

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Nabil Seidah

object named as

Nabil G Seidah

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author name string

Nasha Nassoury

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Daniel A Blasiole

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Angie Tebon Oler

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Suzanne Benjannet

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Josée Hamelin

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Vivianne Poupon

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Peter S McPherson

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Alan D Attie

Novel mutations of the PCSK9 gene cause variable phenotype of autosomal dominant hypercholesterolemia

8

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language of work or name

English

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publication date

June 2007

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published in

Traffic

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volume

8

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page(s)

718-32

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issue

6

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cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

A mutation in PCSK9 causing autosomal-dominant hypercholesterolemia in a Utah pedigree

1 reference

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7 January 2021

Complementation of mutations in the LDL pathway of receptor-mediated endocytosis by cocultivation of LDL receptor-defective hamster cell mutants

1 reference

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7 January 2021

Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic

1 reference

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7 January 2021

Dual regulation of the LDL receptor--some clarity and new questions

1 reference

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7 January 2021

Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides

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7 January 2021

The p65 domain from NF-kappaB is an efficient human activator in the tetracycline-regulatable gene expression system

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

Human and mouse proteases: a comparative genomic approach

1 reference

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7 January 2021

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

1 reference

7 January 2021

Neuroendocrine secretory protein 7B2: structure, expression and functions

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

Precursor convertases in the secretory pathway, cytosol and extracellular milieu

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

Soluble LDL-R are formed by cell surface cleavage in response to phorbol esters

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

7B2 is a specific intracellular binding protein of the prohormone convertase PC2

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

Endoplasmic reticulum localization of the low density lipoprotein receptor mediates presecretory degradation of apolipoprotein B

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

1 reference

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7 January 2021

Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

Biosynthesis and cellular trafficking of the convertase SKI-1/S1P: ectodomain shedding requires SKI-1 activity

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol

1 reference

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7 January 2021

Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipase

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

A proteomic approach for the identification of cell-surface proteins shed by metalloproteases

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

Effect of mutations in the PCSK9 gene on the cell surface LDL receptors

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

Molecular mechanisms of autosomal recessive hypercholesterolemia.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

Implication of the proprotein convertase NARC-1/PCSK9 in the development of the nervous system

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

LRP: role in vascular wall integrity and protection from atherosclerosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

Vesicle formation at the plasma membrane and trans-Golgi network: the same but different

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

Expression and localization of PCSK9 in rat hepatic cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

The role of the LDL receptor in apolipoprotein B secretion

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021

Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-0854.2007.00562.X

7 January 2021