Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH (Q24297165)

GOA release 2020-03-11

Paola Lo Surdo

1

Paola

Lo Surdo

1 reference

19 October 2023

Matthew J Bottomley

2

Matthew J

Bottomley

1 reference

19 October 2023

Alessandra Calzetta

3

Alessandra

Calzetta

1 reference

19 October 2023

Ethan C Settembre

4

Ethan C

Settembre

1 reference

19 October 2023

Agostino Cirillo

5

Agostino

Cirillo

1 reference

19 October 2023

Shilpa Pandit

6

Shilpa

Pandit

1 reference

19 October 2023

Yan G Ni

7

Yan G

Ni

1 reference

19 October 2023

Brian Hubbard

8

Brian

Hubbard

1 reference

19 October 2023

Ayesha Sitlani

9

Ayesha

Sitlani

1 reference

19 October 2023

Andrea Carfí

10

Andrea

Carfí

1 reference

Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels

19 October 2023

language of work or name

English

0 references

publication date

December 2011

0 references

published in

EMBO Reports

0 references

volume

12

0 references

issue

12

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page(s)

1300-5

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

Structural and biochemical characterization of the wild type PCSK9-EGF(AB) complex and natural familial hypercholesterolemia mutants

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

Molecular basis for LDL receptor recognition by PCSK9

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

The self-inhibited structure of full-length PCSK9 at 1.9 A reveals structural homology with resistin within the C-terminal domain

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

The crystal structure of PCSK9: a regulator of plasma LDL-cholesterol

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

Structure of the LDL receptor extracellular domain at endosomal pH

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

In vivo evidence that furin from hepatocytes inactivates PCSK9

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

A receptor-mediated pathway for cholesterol homeostasis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

A two-step binding model of PCSK9 interaction with the low density lipoprotein receptor

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

Regulatory effects of peptides from the pro and catalytic domains of proprotein convertase subtilisin/kexin 9 (PCSK9) on low-density lipoprotein receptor (LDL-R).

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

A proprotein convertase subtilisin-like/kexin type 9 (PCSK9) C-terminal domain antibody antigen-binding fragment inhibits PCSK9 internalization and restores low density lipoprotein uptake

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

Model of human low-density lipoprotein and bound receptor based on cryoEM

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

Mutations and polymorphisms in the proprotein convertase subtilisin kexin 9 (PCSK9) gene in cholesterol metabolism and disease.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

PCSK9: a convertase that coordinates LDL catabolism

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

Mechanism of low density lipoprotein (LDL) release in the endosome: implications of the stability and Ca2+ affinity of the fifth binding module of the LDL receptor.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

Effects of pH and low density lipoprotein (LDL) on PCSK9-dependent LDL receptor regulation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

Mutational analysis of the ligand binding domain of the low density lipoprotein receptor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

Release of low density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

Mechanism of LDL binding and release probed by structure-based mutagenesis of the LDL receptor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

The epidermal growth factor homology domain of the LDL receptor drives lipoprotein release through an allosteric mechanism involving H190, H562, and H586.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

Different combinations of cysteine-rich repeats mediate binding of low density lipoprotein receptor to two different proteins

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3245695

Cooperation between fixed and low pH-inducible interfaces controls lipoprotein release by the LDL receptor

30 May 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FEMBOR.2011.205

Update and analysis of the University College London low density lipoprotein receptor familial hypercholesterolemia database

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FEMBOR.2011.205

Affinity and kinetics of proprotein convertase subtilisin/kexin type 9 binding to low-density lipoprotein receptors on HepG2 cells

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/22081141

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Vesicle-reconstituted low density lipoprotein receptor. Visualization by cryoelectron microscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22081141

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FEMBOR.2011.205

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/EMBOR.2011.205

1 reference

release_oanzg34llbasvi43ynuu7ftdou

Fatcat ID

0 references

1 reference

1 reference

1 reference