Activation gating of hERG potassium channels: S6 glycines are not required as gating hinges. (Q42630920)

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6 January 2020

title

Activation gating of hERG potassium channels: S6 glycines are not required as gating hinges (English)

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6 January 2020

2

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Mike Sutcliffe

4

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6 January 2020

John S Mitcheson

5

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6 January 2020

author name string

Rachael M Hardman

1

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6 January 2020

Sarah Dalibalta

3

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6 January 2020

language of work or name

English

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publication date

6 September 2007

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Journal of Biological Chemistry

6 January 2020

published in

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volume

282

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issue

44

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page(s)

31972-31981

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Expression and Role of hERG Channels in Cancer Cells

6 January 2020

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Investigating the putative glycine hinge in Shaker potassium channel.

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A gating hinge in Na+ channels; a molecular switch for electrical signaling

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Structure and dynamics of K channel pore-lining helices: a comparative simulation study

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Gating of shaker-type channels requires the flexibility of S6 caused by prolines

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Sequence-Function Analysis of the K+-Selective Family of Ion Channels Using a Comprehensive Alignment and the KcsA Channel Structure

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Effect of alanine versus glycine in alpha-helices on protein stability

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Reversed voltage-dependent gating of a bacterial sodium channel with proline substitutions in the S6 transmembrane segment

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A structural basis for drug-induced long QT syndrome

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Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes.

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Structural determinants of HERG channel block by clofilium and ibutilide.

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Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate.

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Drug binding interactions in the inner cavity of HERG channels: molecular insights from structure-activity relationships of clofilium and ibutilide analogs

21 January 2018

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Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution

21 January 2018

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Differential roles of S6 domain hinges in the gating of KCNQ potassium channels.

21 January 2018

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21 January 2018

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The Selectivity Filter May Act as the Agonist-activated Gate in the G Protein-activated Kir3.1/Kir3.4 K+ Channel

21 January 2018

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Detection of the opening of the bundle crossing in KcsA with fluorescence lifetime spectroscopy reveals the existence of two gates for ion conduction

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21 January 2018

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The S4-S5 linker directly couples voltage sensor movement to the activation gate in the human ether-a'-go-go-related gene (hERG) K+ channel.

21 January 2018

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Interactions between S4-S5 linker and S6 transmembrane domain modulate gating of HERG K+ channels

21 January 2018

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21 January 2018

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21 January 2018

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Identifiers

DOI

10.1074/JBC.M705835200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17823114%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

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