v-SRC specifically regulates the nucleo-cytoplasmic delocalization of the major isoform of TEL (ETV6). (Q42798686)

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6 November 2019

title

v-SRC specifically regulates the nucleo-cytoplasmic delocalization of the major isoform of TEL (ETV6) (English)

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6 November 2019

2

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6 November 2019

author name string

Rodolphe G Lopez

series ordinal

1

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6 November 2019

Jacques Ghysdael

series ordinal

3

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6 November 2019

language of work or name

English

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publication date

31 July 2003

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Journal of Biological Chemistry

6 November 2019

number of pages

10

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based on heuristic

inferred from page(s)

published in

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6 November 2019

volume

278

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6 November 2019

issue

42

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6 November 2019

page(s)

41316-41325

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The role of TEL fusion genes in pediatric leukemias

6 November 2019

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The leukemia-associated gene TEL encodes a transcription repressor which associates with SMRT and mSin3A.

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Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein

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The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6)

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The acetyltransferase 60 kDa trans-acting regulatory protein of HIV type 1-interacting protein (Tip60) interacts with the translocation E26 transforming-specific leukaemia gene (TEL) and functions as a transcriptional co-repressor

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Small ubiquitin-like modifier conjugation regulates nuclear export of TEL, a putative tumor suppressor

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DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma

21 January 2018

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Analysis of TEL proteins in human leukemias

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Transport between the cell nucleus and the cytoplasm

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The hunting of the Src

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Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway.

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The SMRT corepressor is regulated by a MEK-1 kinase pathway: inhibition of corepressor function is associated with SMRT phosphorylation and nuclear export

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Comparative analysis of the ETV6 gene in vertebrate genomes from pufferfish to human.

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TEL, a putative tumor suppressor, modulates cell growth and cell morphology of ras-transformed cells while repressing the transcription of stromelysin-1.

21 January 2018

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Tel induces a G1 arrest and suppresses Ras-induced transformation

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A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression

21 January 2018

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Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation

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Identifiers

DOI

10.1074/JBC.M306435200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12893822%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

1 reference