Src-CrkII-C3G-dependent Activation of Rap1 Switches Growth Hormone-stimulated p44/42 MAP Kinase and JNK/SAPK Activities (Q42802113)

7 November 2017

Src-CrkII-C3G-dependent activation of Rap1 switches growth hormone-stimulated p44/42 MAP kinase and JNK/SAPK activities (English)

1 reference

7 November 2017

Src-CrkII-C3G-dependent Activation of Rap1 Switches Growth Hormone-stimulated p44/42 MAP Kinase and JNK/SAPK Activities (English)

1 reference

https://api.crossref.org/works/10.1074/JBC.M302516200

31 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M302516200

31 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M302516200

31 December 2023

author name string

Ling Ling

1

1 reference

7 November 2017

Tao Zhu

2

1 reference

7 November 2017

Peter E. Lobie

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12734187

31 December 2023

language of work or name

English

0 references

publication date

6 May 2003

1 reference

full work available at URL

7 November 2017

11

1 reference

based on heuristic

inferred from page(s)

http://www.jbc.org/article/S0021925820846997/pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12734187

https://api.elsevier.com/content/article/PII:S0021925820846997?httpAccept=text/xml

31 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M302516200

https://api.elsevier.com/content/article/PII:S0021925820846997?httpAccept=text/plain

31 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M302516200

https://syndication.highwire.org/content/doi/10.1074/jbc.M302516200

31 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M302516200

Journal of Biological Chemistry

31 December 2023

published in

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7 November 2017

278

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7 November 2017

29

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7 November 2017

27301-27311

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Rap1 signalling: adhering to new models

7 November 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

JAK2, Ras, and Raf are required for activation of extracellular signal-regulated kinase/mitogen-activated protein kinase by growth hormone

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Regulation of Ras-mediated signalling: more than one way to skin a cat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

C3G, a guanine nucleotide exchange factor bound to adapter molecule c-Crk, has two alternative splicing forms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Direct binding of p130(Cas) to the guanine nucleotide exchange factor C3G

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Two species of human CRK cDNA encode proteins with distinct biological activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Role of Crk oncogene product in physiologic signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Activation of C3G guanine nucleotide exchange factor for Rap1 by phosphorylation of tyrosine 504.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Signal transduction via the growth hormone receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Growth hormone stimulates the formation of a multiprotein signaling complex involving p130(Cas) and CrkII. Resultant activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Growth hormone stimulates the tyrosine phosphorylation and association of p125 focal adhesion kinase (FAK) with JAK2. Fak is not required for stat-mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Mediation of growth hormone-dependent transcriptional activation by mammary gland factor/Stat 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Identification of a JAK2-independent pathway regulating growth hormone (GH)-stimulated p44/42 mitogen-activated protein kinase activity. GH activation of Ral and phospholipase D is Src-dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Activation of the small GTPase Ral in platelets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Rapid Ca2+-mediated activation of Rap1 in human platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Differential binding to and regulation of JAK2 by the SH2 domain and N-terminal region of SH2-bbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

c-Src kinase activity is required for hepatocyte growth factor-induced motility and anchorage-independent growth of mammary carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Growth hormone stimulates phosphorylation and activation of elk-1 and expression of c-fos, egr-1, and junB through activation of extracellular signal-regulated kinases 1 and 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Plasma membrane recruitment of RalGDS is critical for Ras-dependent Ral activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

CrkII participation in the cellular effects of growth hormone and insulin-like growth factor-1. Phosphatidylinositol-3 kinase dependent and independent effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

SH2-Bbeta is a Rac-binding protein that regulates cell motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Rap1 is activated by erythropoietin or interleukin-3 and is involved in regulation of beta1 integrin-mediated hematopoietic cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Activity of Rap1 is regulated by bombesin, cell adhesion, and cell density in NIH3T3 fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Integrins: a family of cell surface receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Identification of a novel beta-catenin-interacting protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

A mechanism of Bud1p GTPase action suggested by mutational analysis and immunolocalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Interaction of the low-molecular-weight GTP-binding protein rap2 with the platelet cytoskeleton is mediated by direct binding to the actin filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Growth control in mammalian cells by cell-cell contacts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

PKA phosphorylation of Src mediates cAMP's inhibition of cell growth via Rap1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

The CrkL adapter protein is required for type I interferon-dependent gene transcription and activation of the small G-protein Rap1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Focal adhesions require catalytic activity of Src family kinases to mediate integrin-matrix adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

c-Src signaling induced by the adapters Sin and Cas is mediated by Rap1 GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Evidence for an Endogenous Ultradian Rhythm Governing Growth Hormone Secretion in the Rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Development of anticancer drugs targeting the MAP kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Downstream of Crk adaptor signaling pathway: activation of Jun kinase by v-Crk through the guanine nucleotide exchange protein C3G.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Guanine-nucleotide exchange protein C3G activates JNK1 by a ras-independent mechanism. JNK1 activation inhibited by kinase negative forms of MLK3 and DLK mixed lineage kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Interaction of the Nck adapter protein with p21-activated kinase (PAK1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Requirement for protein-tyrosine phosphatase SHP-2 in insulin-induced activation of c-Jun NH(2)-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Crk activation of JNK via C3G and R-Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

The c-Jun transcription factor--bipotential mediator of neuronal death, survival and regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Diverse functions of JNK signaling and c-Jun in stress response and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Phosphorylation of c-jun mediated by MAP kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302516200

21 January 2018

2

49

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1989

1 reference

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Janus kinase 2-dependent activation of p38 mitogen-activated protein kinase by growth hormone. Resultant transcriptional activation of ATF-2 and CHOP, cytoskeletal re-organization and mitogenesis

31 December 2023

24

1 reference

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Signaling molecules involved in coupling growth hormone receptor to mitogen-activated protein kinase activation

31 December 2023

26

1 reference

https://api.crossref.org/works/10.1074/JBC.M302516200

Growth Hormone Induction of Hepatic Serine Protease Inhibitor 2.1 Transcription Is Mediated by a Stat5-related Factor Binding Synergistically to Two γ-Activated Sites

31 December 2023

28

1 reference

https://api.crossref.org/works/10.1074/JBC.M302516200

Growth hormone increases calcium uptake in rat fat cells by a mechanism dependent on protein kinase C

31 December 2023

32

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Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1

31 December 2023

55

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Divergent roles for Ras and Rap in the activation of p38 mitogen-activated protein kinase by interleukin-1

31 December 2023

56

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https://api.crossref.org/works/10.1074/JBC.M302516200

RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts

31 December 2023

57

1 reference

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Colocalization of Ras and Ral on the membrane is required for Ras-dependent Ral activation through Ral GDP dissociation stimulator

31 December 2023

60

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The activation of RalGDS can be achieved independently of its Ras binding domain. Implications of an activation mechanism in Ras effector specificity and signal distribution

31 December 2023

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31 December 2023

Identifiers

1 reference

7 November 2017

1 reference