Hydrogen bonding progressively strengthens upon transfer of the protein urea-denatured state to water and protecting osmolytes. (Q42921421)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20073511%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

title

Hydrogen bonding progressively strengthens upon transfer of the protein urea-denatured state to water and protecting osmolytes (English)

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16 January 2020

2

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16 January 2020

author name string

Luis Marcelo F Holthauzen

series ordinal

1

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16 January 2020

D Wayne Bolen

series ordinal

3

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16 January 2020

language of work or name

English

0 references

publication date

1 February 2010

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16 January 2020

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16 January 2020

volume

49

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16 January 2020

issue

6

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16 January 2020

page(s)

1310-1318

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Urea, but not guanidinium, destabilizes proteins by forming hydrogen bonds to the peptide group.

16 January 2020

cites work

1 reference

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Intrinsically Disordered Proteins in Human Diseases: Introducing the D 2 Concept

27 May 2018

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Structure and energetics of the hydrogen-bonded backbone in protein folding.

27 May 2018

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Anatomy of energetic changes accompanying urea-induced protein denaturation.

27 May 2018

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Mixed osmolytes: the degree to which one osmolyte affects the protein stabilizing ability of another

27 May 2018

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27 May 2018

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End-to-end distance distributions and intrachain diffusion constants in unfolded polypeptide chains indicate intramolecular hydrogen bond formation

27 May 2018

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27 May 2018

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Reassessing random-coil statistics in unfolded proteins

27 May 2018

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Random-coil behavior and the dimensions of chemically unfolded proteins

27 May 2018

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Some factors in the interpretation of protein denaturation

27 May 2018

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Measuring the stability of partly folded proteins using TMAO.

27 May 2018

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Osmolyte effects on helix formation in peptides and the stability of coiled-coils

27 May 2018

1 reference

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Polyproline II structure in a sequence of seven alanine residues.

27 May 2018

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Natively unfolded proteins: a point where biology waits for physics

27 May 2018

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The molecular mechanism of stabilization of proteins by TMAO and its ability to counteract the effects of urea

27 May 2018

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The osmophobic effect: natural selection of a thermodynamic force in protein folding

27 May 2018

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Interpreting the effects of small uncharged solutes on protein-folding equilibria.

27 May 2018

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Linked folding and anion binding of the Bacillus subtilis ribonuclease P protein

27 May 2018

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The ankyrin repeat: a diversity of interactions on a common structural framework

27 May 2018

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Osmolyte-driven contraction of a random coil protein

27 May 2018

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Ultrafast signals in protein folding and the polypeptide contracted state

27 May 2018

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A naturally occurring protective system in urea-rich cells: mechanism of osmolyte protection of proteins against urea denaturation

27 May 2018

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The control of protein stability and association by weak interactions with water: how do solvents affect these processes?

27 May 2018

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Urea unfolding of peptide helices as a model for interpreting protein unfolding

27 May 2018

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Living with water stress: evolution of osmolyte systems

27 May 2018

1 reference

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Urea and guanidine hydrochloride denaturation of ribonuclease, lysozyme, alpha-chymotrypsin, and beta-lactoglobulin.

27 May 2018

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Theory for the folding and stability of globular proteins

27 May 2018

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How does protein folding get started?

27 May 2018

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Dominant forces in protein folding

27 May 2018

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Role of backbone-solvent interactions in determining conformational equilibria of intrinsically disordered proteins

27 May 2018

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Interactions between hydrophobic and ionic solutes in aqueous guanidinium chloride and urea solutions: lessons for protein denaturation mechanism.

16 August 2018

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16 August 2018

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Effects of naturally occurring osmolytes on protein stability and solubility: issues important in protein crystallization

16 August 2018

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Osmolytes induce structure in an early intermediate on the folding pathway of barstar

16 August 2018

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Additive transfer free energies of the peptide backbone unit that are independent of the model compound and the choice of concentration scale

16 August 2018

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On the extended beta-conformation propensity of polypeptides at high temperature

16 August 2018

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Osmolyte effects on kinetics of FKBP12 C22A folding coupled with prolyl isomerization

16 August 2018

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Thermodynamics of a diffusional protein folding reaction

16 August 2018

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Fifty years of solvent denaturation.

16 August 2018

1 reference

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Trimethylamine-N-oxide-induced folding of alpha-synuclein.

16 August 2018

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Studies of the ankyrin repeats of the Drosophila melanogaster Notch receptor. 1. Solution conformational and hydrodynamic properties

16 August 2018

1 reference

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Trimethylamine N-oxide-induced cooperative folding of an intrinsically unfolded transcription-activating fragment of human glucocorticoid receptor.

16 August 2018

1 reference

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Use of fast protein size-exclusion liquid chromatography to study the unfolding of proteins which denature through the molten globule

16 August 2018

1 reference

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Thermodynamic analysis of interactions between denaturants and protein surface exposed on unfolding: interpretation of urea and guanidinium chloride m-values and their correlation with changes in accessible surface area (ASA) using preferential inte

16 August 2018

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12 December 2020

The chicken-egg scenario of protein folding revisited

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12 December 2020

Computational simulation of the statistical properties of unfolded proteins

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12 December 2020

[Thermodynamics of hydrophobic interaction in the systems water + glycin + urea and water + alanin + urea at 25 degrees C (author's transl)]

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12 December 2020

Protein interactions with urea and guanidinium chloride. A calorimetric study

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12 December 2020

The peptide backbone plays a dominant role in protein stabilization by naturally occurring osmolytes

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12 December 2020

Forcing thermodynamically unfolded proteins to fold

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12 December 2020

Interdomain signaling in a two-domain fragment of the human glucocorticoid receptor

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12 December 2020

THE SOLUBILITY OF AMINO ACIDS AND RELATED COMPOUNDS IN AQUEOUS UREA SOLUTIONS

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12 December 2020

THE EFFECT OF COMPOUNDS OF THE UREA-GUANIDINIUM CLASS ON THE ACTIVITY COEFFICIENT OF ACETYLTETRAGLYCINE ETHYL ESTER AND RELATED COMPOUNDS

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12 December 2020

Application of the transfer model to understand how naturally occurring osmolytes affect protein stability

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12 December 2020

Identifiers

DOI

10.1021/BI9015499

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20073511%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20073511%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference