The power of reversibility regulating gene activities via tetracycline-controlled transcription (Q42941337)

11 November 2017

The power of reversibility regulating gene activities via tetracycline-controlled transcription (English)

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11 November 2017

1 reference

Kai Schönig

1

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11 November 2017

Hermann Bujard

series ordinal

2

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11 November 2017

Manfred Gossen

series ordinal

3

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11 November 2017

language of work or name

English

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publication date

1 January 2010

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11 November 2017

Methods in Enzymology

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11 November 2017

477

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11 November 2017

429-453

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https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

11 November 2017

1 reference

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Cell-specific expression of wild-type MeCP2 in mouse models of Rett syndrome yields insight about pathogenesis.

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A practical summary of site-specific recombination, conditional mutagenesis, and tamoxifen induction of CreERT2.

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Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture

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7 January 2021

Co-regulation of two gene activities by tetracycline via a bidirectional promoter.

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7 January 2021

Modified GFAP promoter auto-regulates tet-activator expression for increased transactivation and reduced tTA-associated toxicity

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Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells

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7 January 2021

Transgenic calmodulin-dependent protein kinase II activation: dose-dependent effects on synaptic plasticity, learning, and memory.

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7 January 2021

Gene regulation by tetracyclines. Constraints of resistance regulation in bacteria shape TetR for application in eukaryotes

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7 January 2021

Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells

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7 January 2021

Capture of authentic embryonic stem cells from rat blastocysts

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7 January 2021

Single-gene transgenic mouse strains for reprogramming adult somatic cells

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7 January 2021

Select overexpression of homer1a in dorsal hippocampus impairs spatial working memory

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7 January 2021

Lessons from Nature: microRNA-based shRNA libraries

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7 January 2021

Transgenic animals with inducible, targeted gene expression in brain.

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7 January 2021

Characterization of tetracycline-inducible bitransgenic Krt12rtTA/+/tet-O-LacZ mice

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Essential role for oncogenic Ras in tumour maintenance

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7 January 2021

Viral evolution as a tool to improve the tetracycline-regulated gene expression system

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7 January 2021

Tetracycline-reversible silencing of eukaryotic promoters

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7 January 2021

Inducible endothelial cell-specific gene expression in transgenic mouse embryos and adult mice

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7 January 2021

Conditional gene expression in the epidermis of transgenic mice using the tetracycline-regulated transactivators tTA and rTA linked to the keratin 5 promoter

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Tissue-specific and reversible RNA interference in transgenic mice

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E- and P-selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice

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Temporally regulated overexpression of parathyroid hormone-related protein in the mammary gland reveals distinct fetal and pubertal phenotypes.

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7 January 2021

The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy

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7 January 2021

Conditional transformation of a pancreatic beta-cell line derived from transgenic mice expressing a tetracycline-regulated oncogene

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7 January 2021

Reversing cancer from inside and out: oncogene addiction, cellular senescence, and the angiogenic switch

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7 January 2021

Reversible tumorigenesis by MYC in hematopoietic lineages

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7 January 2021

Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells

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7 January 2021

Use of tetracycline-controlled gene expression systems to study mammalian cell cycle.

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7 January 2021

Forebrain-specific neuronal inhibition of nuclear factor-kappaB activity leads to loss of neuroprotection.

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Getting around lethality with inducible Cre-mediated excision

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Knockout rats via embryo microinjection of zinc-finger nucleases

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A transgenic mouse model with inducible Tyrosinase gene expression using the tetracycline (Tet-on) system allows regulated rescue of abnormal chiasmatic projections found in albinism

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Genetic ablation and restoration of the olfactory topographic map.

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7 January 2021

Conditional gene expression: intelligent designs

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7 January 2021

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

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7 January 2021

Studying gene function in eukaryotes by conditional gene inactivation

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7 January 2021

Control of gene activity in higher eukaryotic cells by prokaryotic regulatory elements

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Transcriptional activation by tetracyclines in mammalian cells

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Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult

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A novel doxycycline-inducible system for the transgenic analysis of mammary gland biology

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Conditional and targeted overexpression of vascular chymase causes hypertension in transgenic mice

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A system for inducible gene expression in retinal ganglion cells

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Regulation of the development of mesencephalic dopaminergic systems by the selective expression of glial cell line-derived neurotrophic factor in their targets.

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Progress toward the clinical application of patient-specific pluripotent stem cells

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Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice

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Cancer. The metastasis cascade

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Transient early-life forebrain corticotropin-releasing hormone elevation causes long-lasting anxiogenic and despair-like changes in mice

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Tet system in the brain: transgenic rats and lentiviral vectors approach.

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Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis.

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Inducible transgenic rat model for diabetes mellitus based on shRNA-mediated gene knockdown

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7 January 2021

A genetic switch for epilepsy in adult mice.

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7 January 2021

Conditional RNAi: towards a silent gene therapy

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Conditional lineage ablation to model human diseases

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The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse

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Role of the forkhead transcription family member, FKHR, in thymocyte differentiation.

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Germline competent embryonic stem cells derived from rat blastocysts

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VEGF is required for dendritogenesis of newly born olfactory bulb interneurons

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Conditional restoration of hippocampal synaptic potentiation in Glur-A-deficient mice

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Inducible and reversible gene expression with the rtTA system for the study of memory.

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Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory.

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Transgenic mice with defined combinations of drug-inducible reprogramming factors

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7 January 2021

The vagaries of variegating transgenes

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Control of memory formation through regulated expression of a CaMKII transgene

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Inducible and neuron-specific gene expression in the adult mouse brain with the rtTA2S-M2 system.

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The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy.

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Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning

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mGluR2 acts through inhibitory Galpha subunits to regulate transmission and long-term plasticity at hippocampal mossy fiber-CA3 synapses

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Targeted transgenesis at the HPRT locus: an efficient strategy to achieve tightly controlled in vivo conditional expression with the tet system

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Regulated expression of foreign genes in vivo after germline transfer.

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Amyloid plaque and neurofibrillary tangle pathology in a regulatable mouse model of Alzheimer's disease

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Seeding and propagation of untransformed mouse mammary cells in the lung

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Nogo-A expressed in Schwann cells impairs axonal regeneration after peripheral nerve injury

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Requirement for p38 mitogen-activated protein kinase activity in neointima formation after vascular injury

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Transgenic targeting with regulatory elements of the human CD34 gene

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Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L).

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7 January 2021

Generation of a tightly regulated doxycycline-inducible model for studying mouse intestinal biology

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7 January 2021

Tau suppression in a neurodegenerative mouse model improves memory function

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7 January 2021

Conditional transgene expression in endothelial cells.

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Stringent doxycycline dependent control of CRE recombinase in vivo

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Reversible gene knockdown in mice using a tight, inducible shRNA expression system

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The role of GDNF in patterning the excretory system

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Generation and characterization of a Tet-On (rtTA-M2) transgenic rat

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NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation.

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7 January 2021

Induced pluripotent stem cells generated without viral integration

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A versatile tool for conditional gene expression and knockdown

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

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Inducible and selective transgene expression in murine vascular endothelium

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Conditional expression of fibroblast growth factor-7 in the developing and mature lung.

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Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity

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Codon optimization markedly improves doxycycline regulated gene expression in the mouse heart

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Enhanced CREB-dependent gene expression increases the excitability of neurons in the basal amygdala and primes the consolidation of contextual and cued fear memory.

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Conditional expression of K-ras in an epithelial compartment that includes the stem cells is sufficient to promote squamous cell carcinogenesis.

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7 January 2021

Transgenic silencing of neurons in the mammalian brain by expression of the allatostatin receptor (AlstR)

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Inducible expression of coding and inhibitory RNAs from retargetable genomic loci

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Leaving home early: reexamination of the canonical models of tumor progression.

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7 January 2021

A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types

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7 January 2021

Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle

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Repressible transgenic model of NRAS oncogene-driven mast cell disease in the mouse

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7 January 2021

piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells

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7 January 2021

Conditional expression of the ErbB2 oncogene elicits reversible hyperplasia in stratified epithelia and up-regulation of TGFalpha expression in transgenic mice

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7 January 2021

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

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7 January 2021

Regulated expression of the human CFTR gene in epithelial cells

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Divergent roles of endothelial NF-kappaB in multiple organ injury and bacterial clearance in mouse models of sepsis

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Development of a unique system for spatiotemporal and lineage-specific gene expression in mice

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Impaired neural development caused by inducible expression of Axin in transgenic mice

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An inducible and reversible mouse genetic rescue system

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7 January 2021

Optimization of the Tet-On system for regulated gene expression through viral evolution

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7 January 2021

Developing tTA transgenic rats for inducible and reversible gene expression

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7 January 2021

Forebrain overexpression of CK1delta leads to down-regulation of dopamine receptors and altered locomotor activity reminiscent of ADHD.

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https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

Silencing and un-silencing of tetracycline-controlled genes in neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2810%2977022-1

7 January 2021

10.1016/S0076-6879(10)77022-1

Identifiers

DOI

1 reference

11 November 2017

1 reference