Differential aetiology and impact of phosphoinositide 3-kinase (PI3K) and Akt signalling in skeletal muscle on in vivo insulin action. (Q43050403)

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4 February 2020

title

Differential aetiology and impact of phosphoinositide 3-kinase (PI3K) and Akt signalling in skeletal muscle on in vivo insulin action (English)

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3

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Martin Friedrichsen

1

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Jesper B Birk

5

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Jørgen Wojtaszewski

11

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author name string

P Poulsen

2

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B F Hansen

4

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R Ribel-Madsen

6

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K Stender-Petersen

7

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E Nilsson

8

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H Beck-Nielsen

9

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A Vaag

10

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publication date

29 May 2010

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4 February 2020

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volume

53

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issue

9

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page(s)

1998-2007

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https://scigraph.springernature.com/pub.10.1007/s00125-010-1795-8

4 February 2020

exact match

0 references

cites work

Function and dysfunction of aPKC isoforms for glucose transport in insulin-sensitive and insulin-resistant states

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Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients

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Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects

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Normal insulin-stimulated endothelial function and impaired insulin-stimulated muscle glucose uptake in young adults with low birth weight

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siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle

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Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients

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The intrauterine environment as reflected by birth size and twin and zygosity status influences insulin action and intracellular glucose metabolism in an age- or time-dependent manner

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Regular exercise enhances insulin activation of IRS-1-associated PI3-kinase in human skeletal muscle

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Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects

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Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation

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Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160.

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Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

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Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles

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Impaired insulin-stimulated phosphorylation of Akt and AS160 in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment.

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Plasma cytokine levels in young and elderly twins: genes versus environment and relation to in vivo insulin action

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Altered PI3-kinase/Akt signalling in skeletal muscle of young men with low birth weight

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Skeletal muscle insulin signaling defects downstream of phosphatidylinositol 3-kinase at the level of Akt are associated with impaired nonoxidative glucose disposal in HIV lipodystrophy

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Partial rescue of in vivo insulin signalling in skeletal muscle by impaired insulin clearance in heterozygous carriers of a mutation in the insulin receptor gene

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Low birth weight and zygosity status is associated with defective muscle glycogen and glycogen synthase regulation in elderly twins.

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Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle

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Reduced skeletal muscle inhibitor of kappaB beta content is associated with insulin resistance in subjects with type 2 diabetes: reversal by exercise training

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12 December 2020

Low birthweight is associated with specific changes in muscle insulin-signalling protein expression

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12 December 2020

Dissociation between skeletal muscle inhibitor-kappaB kinase/nuclear factor-kappaB pathway activity and insulin sensitivity in nondiabetic twins

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Glucose intolerance and aging

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Exercise training increases glycogen synthase activity and GLUT4 expression but not insulin signaling in overweight nondiabetic and type 2 diabetic subjects

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Age-dependent nongenetic influences of birth weight and adult body fat on insulin sensitivity in twins

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12 December 2020

Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes

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12 December 2020

Cellular mechanisms of insulin resistance

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12 December 2020

Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation

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12 December 2020