Increased levels of peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC-1alpha) improve lipid utilisation, insulin signalling and glucose transport in skeletal muscle of lean and insulin-resistant obese Zucker rats (Q43057678)

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scientific article published on 20 May 2010

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English	Increased levels of peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC-1alpha) improve lipid utilisation, insulin signalling and glucose transport in skeletal muscle of lean and insulin-resistant obese Zucker rats	scientific article published on 20 May 2010

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scholarly article

1 reference

Europe PubMed Central

13 November 2017

Increased levels of peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC-1alpha) improve lipid utilisation, insulin signalling and glucose transport in skeletal muscle of lean and insulin-resistant obese Zucker rats (English)

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Europe PubMed Central

13 November 2017

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insulin resistance

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Adrian Chabowski

object named as

A Chabowski

9

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author name string

C R Benton

1

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Europe PubMed Central

13 November 2017

G P Holloway

2

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Europe PubMed Central

13 November 2017

X-X Han

3

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Europe PubMed Central

13 November 2017

Y Yoshida

4

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Europe PubMed Central

13 November 2017

L A Snook

5

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Europe PubMed Central

13 November 2017

J Lally

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Europe PubMed Central

13 November 2017

J F C Glatz

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Europe PubMed Central

13 November 2017

J J F P Luiken

8

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Europe PubMed Central

13 November 2017

A Bonen

10

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Europe PubMed Central

13 November 2017

publication date

20 May 2010

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Europe PubMed Central

13 November 2017

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Europe PubMed Central

13 November 2017

53

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Europe PubMed Central

13 November 2017

9

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Europe PubMed Central

13 November 2017

2008-2019

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Europe PubMed Central

13 November 2017

https://scigraph.springernature.com/pub.10.1007/s00125-010-1773-1

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Intramuscular lipid oxidation and obesity

1 reference

https://api.crossref.org/works/10.1007%2FS00125-010-1773-1

21 January 2018

Optimal salt concentration of vehicle for plasmid DNA enhances gene transfer mediated by electroporation

1 reference

https://api.crossref.org/works/10.1007%2FS00125-010-1773-1

21 January 2018

PPARγ coactivator-1α expression during thyroid hormone- and contractile activity-induced mitochondrial adaptations

1 reference

https://api.crossref.org/works/10.1007%2FS00125-010-1773-1

21 January 2018

Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36.

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https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Populations of rat skeletal muscle mitochondria after exercise and immobilization

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https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

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Overexpression of membrane-associated fatty acid binding protein (FABPpm) in vivo increases fatty acid sarcolemmal transport and metabolism

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https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

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Rosiglitazone Treatment Enhances Acute AMP-Activated Protein Kinase-Mediated Muscle and Adipose Tissue Glucose Uptake in High-Fat-Fed Rats

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https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

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Role of Akt substrate of 160 kDa in insulin-stimulated and contraction-stimulated glucose transport.

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https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

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Whole body overexpression of PGC-1alpha has opposite effects on hepatic and muscle insulin sensitivity

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https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

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Effects of metformin and rosiglitazone treatment on insulin signaling and glucose uptake in patients with newly diagnosed type 2 diabetes: a randomized controlled study

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https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

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Modest PGC-1alpha overexpression in muscle in vivo is sufficient to increase insulin sensitivity and palmitate oxidation in subsarcolemmal, not intermyofibrillar, mitochondria

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https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency.

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https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

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Metabolic control through the PGC-1 family of transcription coactivators

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https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

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Optimisation of electrotransfer of plasmid into skeletal muscle by pretreatment with hyaluronidase -- increased expression with reduced muscle damage

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https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid exercise-induced changes in PGC-1alpha mRNA and protein in human skeletal muscle

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https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

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Two phases of palmitate-induced insulin resistance in skeletal muscle: impaired GLUT4 translocation is followed by a reduced GLUT4 intrinsic activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

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Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-gamma coactivator-1 and peroxisome proliferator-activated receptor-alpha in skeletal muscle.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

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Lipid mediators of insulin resistance

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https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metformin and exercise reduce muscle FAT/CD36 and lipid accumulation and blunt the progression of high-fat diet-induced hyperglycemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

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Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

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Glucose transport and cell surface GLUT-4 protein in skeletal muscle of the obese Zucker rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PGC-1alpha increases skeletal muscle lactate uptake by increasing the expression of MCT1 but not MCT2 or MCT4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Greater transport efficiencies of the membrane fatty acid transporters FAT/CD36 and FATP4 compared with FABPpm and FATP1 and differential effects on fatty acid esterification and oxidation in rat skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In obese rat muscle transport of palmitate is increased and is channeled to triacylglycerol storage despite an increase in mitochondrial palmitate oxidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DGAT1 expression increases heart triglyceride content but ameliorates lipotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

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Glucose uptake and GLUT-4 protein distribution in skeletal muscle of the obese Zucker rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin resistance of obese Zucker rats exercise trained at two different intensities.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Compensatory increases in nuclear PGC1alpha protein are primarily associated with subsarcolemmal mitochondrial adaptations in ZDF rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

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Retracted: Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-fat diets cause insulin resistance despite an increase in muscle mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

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Fatty acid binding protein facilitates sarcolemmal fatty acid transport but not mitochondrial oxidation in rat and human skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of acute bouts of running and swimming exercise on PGC-1α protein expression in rat epitrochlearis and soleus muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optimizing plasmid-based gene transfer for investigating skeletal muscle structure and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PGC-1alpha-mediated regulation of gene expression and metabolism: implications for nutrition and exercise prescriptions

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Is membrane transport of FFA mediated by lipid, protein, or both? Mechanisms and regulation of protein-mediated cellular fatty acid uptake: molecular, biochemical, and physiological evidence

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of peroxisome proliferator-activated receptor gamma coactivator-1alpha down-regulates GLUT4 mRNA in skeletal muscles

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ultrastructural modification of human skeletal muscle tissue with 6-month moderate-intensity exercise training

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AS160 regulates insulin- and contraction-stimulated glucose uptake in mouse skeletal muscle.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Restoring AS160 phosphorylation rescues skeletal muscle insulin resistance and fatty acid oxidation while not reducing intramuscular lipids

1 reference

https://pubmed.ncbi.nlm.nih.gov/20490453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00125-010-1773-1

1 reference

Europe PubMed Central

13 November 2017

1 reference

Europe PubMed Central

13 November 2017

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