Two phases of palmitate-induced insulin resistance in skeletal muscle: impaired GLUT4 translocation is followed by a reduced GLUT4 intrinsic activity. (Q53856316)

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English	Two phases of palmitate-induced insulin resistance in skeletal muscle: impaired GLUT4 translocation is followed by a reduced GLUT4 intrinsic activity.	scientific article

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scholarly article

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Europe PubMed Central

21 May 2018

http://europepmc.org/abstract/MED/17550999

Two phases of palmitate-induced insulin resistance in skeletal muscle: impaired GLUT4 translocation is followed by a reduced GLUT4 intrinsic activity. (English)

1 reference

Europe PubMed Central

21 May 2018

http://europepmc.org/abstract/MED/17550999

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based on heuristic

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insulin resistance

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based on heuristic

inferred from title

Adrian Chabowski

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Adrian Chabowski

2

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author name string

Hakam Alkhateeb

1

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Europe PubMed Central

21 May 2018

http://europepmc.org/abstract/MED/17550999

Jan F C Glatz

3

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Europe PubMed Central

21 May 2018

http://europepmc.org/abstract/MED/17550999

Joost F P Luiken

4

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Europe PubMed Central

21 May 2018

http://europepmc.org/abstract/MED/17550999

Arend Bonen

5

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Europe PubMed Central

21 May 2018

http://europepmc.org/abstract/MED/17550999

publication date

5 June 2007

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Europe PubMed Central

21 May 2018

http://europepmc.org/abstract/MED/17550999

American Journal of Physiology - Endocrinology and Metabolism

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Europe PubMed Central

21 May 2018

http://europepmc.org/abstract/MED/17550999

293

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21 May 2018

http://europepmc.org/abstract/MED/17550999

3

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Europe PubMed Central

21 May 2018

http://europepmc.org/abstract/MED/17550999

E783-93

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Europe PubMed Central

21 May 2018

http://europepmc.org/abstract/MED/17550999

Ceramide content is increased in skeletal muscle from obese insulin-resistant humans

1 reference

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21 January 2018

Reduction of insulin-stimulated glucose uptake in L6 myotubes by the protein kinase inhibitor SB203580 is independent of p38MAPK activity.

1 reference

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21 January 2018

The p38 mitogen-activated protein kinase inhibitor SB203580 reduces glucose turnover by the glucose transporter-4 of 3T3-L1 adipocytes in the insulin-stimulated state

1 reference

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21 January 2018

Dose-response effect of elevated plasma free fatty acid on insulin signaling

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Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects

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Experimental approaches in muscle metabolism: hindlimb perfusion and isolated muscle incubations

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Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content

1 reference

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A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate

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A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids

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Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes

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Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling

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Impaired expression and insulin-stimulated phosphorylation of Akt-2 in muscle of obese patients with atypical diabetes

1 reference

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Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells.

1 reference

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21 January 2018

Insulin-stimulated plasma membrane association and activation of Akt2, aPKC zeta and aPKC lambda in high fat fed rodent skeletal muscle.

1 reference

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21 January 2018

A structural basis for the acute effects of HIV protease inhibitors on GLUT4 intrinsic activity.

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Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

1 reference

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Indinavir induces acute and reversible peripheral insulin resistance in rats.

1 reference

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Insulin regulates the membrane arrival, fusion, and C-terminal unmasking of glucose transporter-4 via distinct phosphoinositides

1 reference

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21 January 2018

Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

1 reference

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21 January 2018

Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects

1 reference

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Effects of metformin and rosiglitazone treatment on insulin signaling and glucose uptake in patients with newly diagnosed type 2 diabetes: a randomized controlled study

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21 January 2018

A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes

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21 January 2018

Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes

1 reference

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21 January 2018

PKC-theta knockout mice are protected from fat-induced insulin resistance

1 reference

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21 January 2018

Fatty acid infusion selectively impairs insulin action on Akt1 and protein kinase C lambda /zeta but not on glycogen synthase kinase-3.

1 reference

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21 January 2018

Troglitazone but not metformin restores insulin-stimulated phosphoinositide 3-kinase activity and increases p110beta protein levels in skeletal muscle of type 2 diabetic subjects

1 reference

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Identification of a proline-rich Akt substrate as a 14-3-3 binding partner

1 reference

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Resistance training enhances components of the insulin signaling cascade in normal and high-fat-fed rodent skeletal muscle

1 reference

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21 January 2018

DAG accumulation from saturated fatty acids desensitizes insulin stimulation of glucose uptake in muscle cells

1 reference

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21 January 2018

Resistin inhibits glucose uptake in L6 cells independently of changes in insulin signaling and GLUT4 translocation

1 reference

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Indinavir inhibits the glucose transporter isoform Glut4 at physiologic concentrations

1 reference

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Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats

1 reference

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21 January 2018

AMP kinase activation ameliorates insulin resistance induced by free fatty acids in rat skeletal muscle

1 reference

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21 January 2018

Skeletal muscle triglyceride levels are inversely related to insulin action.

1 reference

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21 January 2018

Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism.

1 reference

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21 January 2018

Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells

1 reference

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21 January 2018

Endofacial competitive inhibition of glucose transporter-4 intrinsic activity by the mitogen-activated protein kinase inhibitor SB203580.

1 reference

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Signalling aspects of insulin resistance in skeletal muscle: mechanisms induced by lipid oversupply

1 reference

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Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate

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Cross-talk mechanisms in the development of insulin resistance of skeletal muscle cells palmitate rather than tumour necrosis factor inhibits insulin-dependent protein kinase B (PKB)/Akt stimulation and glucose uptake

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21 January 2018

Turning signals on and off: GLUT4 traffic in the insulin-signaling highway

1 reference

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21 January 2018

Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (zeta/lambda) activities

1 reference

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21 January 2018

Insulin-stimulated glucose uptake does not require p38 mitogen-activated protein kinase in adipose tissue or skeletal muscle

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Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

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21 January 2018

Identifiers

10.1152/AJPENDO.00685.2006

1 reference

Europe PubMed Central

21 May 2018

http://europepmc.org/abstract/MED/17550999

1 reference

Europe PubMed Central

21 May 2018

http://europepmc.org/abstract/MED/17550999

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