P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest (Q43189320)

15 November 2017

P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest (English)

1 reference

15 November 2017

A A Shamseddine

1

1 reference

15 November 2017

C J Clarke

2

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15 November 2017

B Carroll

3

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15 November 2017

M V Airola

4

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15 November 2017

S Mohammed

5

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15 November 2017

A Rella

6

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15 November 2017

L M Obeid

7

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15 November 2017

Y A Hannun

8

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15 November 2017

29 October 2015

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15 November 2017

Cell Death and Disease

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15 November 2017

6

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15 November 2017

e1947

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Creative Commons Attribution 4.0 International

15 November 2017

start time

1 October 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes

25 May 2018

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Src regulates cigarette smoke-induced ceramide generation via neutral sphingomyelinase 2 in the airway epithelium

25 May 2018

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Ceramide modulates pre-mRNA splicing to restore the expression of wild-type tumor suppressor p53 in deletion-mutant cancer cells.

25 May 2018

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Doxorubicin, DNA torsion, and chromatin dynamics

25 May 2018

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Folate stress induces apoptosis via p53-dependent de novo ceramide synthesis and up-regulation of ceramide synthase 6

25 May 2018

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25 May 2018

p53 mutations in cancer

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Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1.

25 May 2018

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Transcriptional regulation of neutral sphingomyelinase 2 in all-trans retinoic acid-treated human breast cancer cell line, MCF-7.

25 May 2018

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Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction

25 May 2018

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Activation of DNA damage response pathways as a consequence of anthracycline-DNA adduct formation

25 May 2018

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The DNA damage response and cancer therapy

25 May 2018

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25 May 2018

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Identification of novel anionic phospholipid binding domains in neutral sphingomyelinase 2 with selective binding preference

25 May 2018

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Neutral sphingomyelinase-2 mediates growth arrest by retinoic acid through modulation of ribosomal S6 kinase

25 May 2018

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Neutral sphingomyelinase 2 (nSMase2) is the primary neutral sphingomyelinase isoform activated by tumour necrosis factor-α in MCF-7 cells

25 May 2018

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The neutral sphingomyelinase family: Identifying biochemical connections

25 May 2018

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The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer

25 May 2018

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The DNA Damage Response: Making It Safe to Play with Knives

25 May 2018

1 reference

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Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase.

25 May 2018

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Mammalian neutral sphingomyelinases: regulation and roles in cell signaling responses

25 May 2018

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Neutral sphingomyelinase 2 (nSMase2) is a phosphoprotein regulated by calcineurin (PP2B)

25 May 2018

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Tumour suppression by p53: a role for the DNA damage response?

25 May 2018

1 reference

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Transcriptional regulation of neutral sphingomyelinase 2 gene expression of a human breast cancer cell line, MCF-7, induced by the anti-cancer drug, daunorubicin

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632297

Neutral sphingomyelinase 2 is activated by cigarette smoke to augment ceramide-induced apoptosis in lung cell death

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632297

Upregulation of smpd3 via BMP2 stimulation and Runx2.

25 May 2018

1 reference

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ATR: an essential regulator of genome integrity

25 May 2018

1 reference

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Neutral sphingomyelinase-3 is a DNA damage and nongenotoxic stress-regulated gene that is deregulated in human malignancies

25 May 2018

1 reference

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Principles of bioactive lipid signalling: lessons from sphingolipids

25 May 2018

1 reference

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Apoptosis induced by capsaicin in prostate PC-3 cells involves ceramide accumulation, neutral sphingomyelinase, and JNK activation

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632297

Reactive nitrogen and oxygen species activate different sphingomyelinases to induce apoptosis in airway epithelial cells

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632297

p53-Independent ceramide formation in human glioma cells during gamma-radiation-induced apoptosis

25 May 2018

1 reference

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Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53.

25 May 2018

1 reference

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Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632297

Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632297

p53-dependent ceramide response to genotoxic stress

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632297

Increases in neutral, Mg2+-dependent and acidic, Mg2+-independent sphingomyelinase activities precede commitment to apoptosis and are not a consequence of caspase 3-like activity in Molt-4 cells in response to thymidylate synthase inhibition by GW18

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632297

Effects of Ara-C on neutral sphingomyelinase and mitogen- and stress-activated protein kinases in T-lymphocyte cell lines

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632297

Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632297

Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632297

Tumor cell resistance to apoptosis due to a defect in the activation of sphingomyelinase and the 24 kDa apoptotic protease (AP24).

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632297

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632297

Increase of ceramide in adriamycin-induced HL-60 cell apoptosis: detection by a novel anti-ceramide antibody

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632297

p53 regulates ceramide formation by neutral sphingomyelinase through reactive oxygen species in human glioma cells

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632297

Ceramide triggers p53-dependent apoptosis in genetically defined fibrosarcoma tumour cells

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632297

Ceramide mimics tumour necrosis factor-alpha in the induction of cell cycle arrest in endothelial cells. Induction of the tumour suppressor p53 with decrease in retinoblastoma/protein levels

15 August 2018

1 reference

12 December 2020

P53 mediates ceramide-induced apoptosis in SKN-SH cells

1 reference

12 December 2020

Ultraviolet B radiation induces activation of neutral and acidic sphingomyelinases and ceramide generation in cultured normal human keratinocytes

1 reference

12 December 2020

The protein kinase C inhibitor Gö6976 is a potent inhibitor of DNA damage-induced S and G2 cell cycle checkpoints

1 reference

12 December 2020

Chemotherapy with or without radiation therapy in limited small-cell carcinoma of the lung

1 reference

12 December 2020

Dose and dose intensity of adjuvant chemotherapy for stage II, node-positive breast carcinoma

1 reference

12 December 2020

Identifiers

DOI

10.1038/CDDIS.2015.268

1 reference

15 November 2017

1 reference

15 November 2017

PubMed publication ID

26512957

1 reference