Overexpression of phospho-eIF4E is associated with survival through AKT pathway in non-small cell lung cancer. (Q43222717)

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15 January 2020

title

Overexpression of phospho-eIF4E is associated with survival through AKT pathway in non-small cell lung cancer (English)

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15 January 2020

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6

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15 January 2020

Takeshi Fujii

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15 January 2020

Junya Fukuoka

2

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15 January 2020

K Shilo

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15 January 2020

author name string

Akihiko Yoshizawa

1

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15 January 2020

Shigeki Shimizu

3

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15 January 2020

Teri J Franks

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15 January 2020

Carlos Cordon-Cardo

8

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Jin Jen

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15 January 2020

William D Travis

10

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language of work or name

English

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publication date

15 December 2009

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15 January 2020

published in

Clinical Cancer Research

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15 January 2020

volume

16

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15 January 2020

issue

1

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page(s)

240-248

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Evaluation of two phosphorylation sites improves the prognostic significance of Akt activation in non-small-cell lung cancer tumors

15 January 2020

cites work

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Optimization of patient selection for gefitinib in non-small cell lung cancer by combined analysis of epidermal growth factor receptor mutation, K-ras mutation, and Akt phosphorylation

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The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

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Exploiting the PI3K/AKT pathway for cancer drug discovery

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Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.

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ERK1/2 is activated in non-small-cell lung cancer and associated with advanced tumours.

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Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer.

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Expression of eukaryotic translation initiation factors 4E and 2alpha is increased frequently in bronchioloalveolar but not in squamous cell carcinomas of the lung

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Elevated levels of eukaryotic translation initiation factor eIF-4E, mRNA in a broad spectrum of transformed cell lines

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High expression of mammalian target of rapamycin is associated with better outcome for patients with early stage lung adenocarcinoma

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Loss of heterozygosity in the tuberous sclerosis gene associated regions in adenocarcinoma of the lung accompanied by multiple atypical adenomatous hyperplasia

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Perturbations of the AKT signaling pathway in human cancer

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Chromatin remodeling factors and BRM/BRG1 expression as prognostic indicators in non-small cell lung cancer.

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Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase

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Elevated phospho-S6 expression is associated with metastasis in adenocarcinoma of the lung

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Immunohistochemical analysis of PTEN in endometrial carcinoma: a tissue microarray study with a comparison of four commercial antibodies in correlation with molecular abnormalities

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12 December 2020

Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo

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12 December 2020

Expression of eukaryotic initiation factor 4E in atypical adenomatous hyperplasia and adenocarcinoma of the human peripheral lung

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12 December 2020

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12 December 2020

Phospho-Akt overexpression in non-small cell lung cancer confers significant stage-independent survival disadvantage

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12 December 2020

Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin

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Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras

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12 December 2020

AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling.

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12 December 2020

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

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Cancer statistics, 2007

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12 December 2020

eIF-4E expression and its role in malignancies and metastases.

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12 December 2020

Fibronectin stimulates non-small cell lung carcinoma cell growth through activation of Akt/mammalian target of rapamycin/S6 kinase and inactivation of LKB1/AMP-activated protein kinase signal pathways

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12 December 2020

10.1158/1078-0432.CCR-09-0986

Identifiers

DOI

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15 January 2020

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