Up-regulating sphingosine 1-phosphate receptor-2 signaling impairs chemotactic, wound-healing, and morphogenetic responses in senescent endothelial cells. (Q43251117)

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scientific article published on 2 September 2008

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English	Up-regulating sphingosine 1-phosphate receptor-2 signaling impairs chemotactic, wound-healing, and morphogenetic responses in senescent endothelial cells.	scientific article published on 2 September 2008

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13 January 2020

Up-regulating sphingosine 1-phosphate receptor-2 signaling impairs chemotactic, wound-healing, and morphogenetic responses in senescent endothelial cells (English)

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13 January 2020

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Christopher D. Kontos

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Rosendo Estrada

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Qun Zeng

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Hongwei Lu

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13 January 2020

Harshini Sarojini

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Jen-Fu Lee

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Teresa Sanchez

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Eugenia Wang

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13 January 2020

Chen-Yong Lin

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Bodduluri Haribabu

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13 January 2020

Menq-Jer Lee

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2 September 2008

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13 January 2020

Journal of Biological Chemistry

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13 January 2020

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13 January 2020

30363-30375

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13 January 2020

Rho GTPases mediated integrin alpha v beta 3 activation in sphingosine-1-phosphate stimulated chemotaxis of endothelial cells

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Principles of bioactive lipid signalling: lessons from sphingolipids

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Ceramide transfer protein function is essential for normal oxidative stress response and lifespan

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CDK2 translational down-regulation during endothelial senescence

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The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation.

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Sphingosine 1-phosphate inhibits migration of RBL-2H3 cells via S1P2: cross-talk between platelets and mast cells.

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Vascular cell senescence and vascular aging

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25 May 2018

Electrical wound-healing assay for cells in vitro

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Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform

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Constitutive activation of rac1 results in mitochondrial oxidative stress and induces premature endothelial cell senescence.

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Protective role of endothelial nitric oxide synthase

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International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature

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Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction

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Cellular senescence as a tumor-suppressor mechanism

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Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis

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Characterization of a novel sphingosine 1-phosphate receptor, Edg-8

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Ceramide induces expression of the senescence histochemical marker, beta-galactosidase, in human fibroblasts.

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Bioactive lysophospholipids and their G protein-coupled receptors

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Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate

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Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins

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Sphingosine-1-phosphate: extracellular mediator or intracellular second messenger?

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1 reference

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1 reference

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Extension of the life-span of human endothelial cells by an interleukin-1 alpha antisense oligomer

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1 reference

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10.1074/JBC.M804392200

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13 January 2020

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13 January 2020

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13 January 2020

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