Overproduction of phosphoprotein enriched in diabetes (PED) induces mesangial expansion and upregulates protein kinase C-beta activity and TGF-beta1 expression. (Q43269412)

From Wikidata

Jump to navigation Jump to search

scientific article published on 30 September 2009

Language	Label	Description	Also known as
English	Overproduction of phosphoprotein enriched in diabetes (PED) induces mesangial expansion and upregulates protein kinase C-beta activity and TGF-beta1 expression.	scientific article published on 30 September 2009

Statements

scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Overproduction of phosphoprotein enriched in diabetes (PED) induces mesangial expansion and upregulates protein kinase C-beta activity and TGF-beta1 expression (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Pietro Formisano

13

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Guido Iaccarino

10

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

author name string

F Oriente

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

S Iovino

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

A Cassese

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

C Romano

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

C Miele

5

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

G Troncone

6

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

M Balletta

7

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

A Perfetti

8

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

G Santulli

9

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

R Valentino

11

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

F Beguinot

12

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

publication date

30 September 2009

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

52

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

12

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

2642-2652

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19789852%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

https://scigraph.springernature.com/pub.10.1007/s00125-009-1528-z

0 references

Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C (PKC) beta modulates serine phosphorylation of insulin receptor substrate-1 (IRS-1)--effect of overexpression of PKCbeta on insulin signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C (PKC)-alpha activation inhibits PKC-zeta and mediates the action of PED/PEA-15 on glucose transport in the L6 skeletal muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning and characterization of the human PED/PEA-15 gene promoter reveal antagonistic regulation by hepatocyte nuclear factor 4alpha and chicken ovalbumin upstream promoter transcription factor II.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple members of the mitogen-activated protein kinase family are necessary for PED/PEA-15 anti-apoptotic function

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth factors and the development of diabetic nephropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microvascular complications of impaired glucose tolerance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High glucose-induced PKC activation mediates TGF-beta 1 and fibronectin synthesis by peritoneal mesothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In L6 skeletal muscle cells, glucose induces cytosolic translocation of protein kinase C-alpha and trans-activates the insulin receptor kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New insights into TGF-beta-Smad signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PED/PEA-15 regulates glucose-induced insulin secretion by restraining potassium channel expression in pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mediators of diabetic renal disease: the case for tgf-Beta as the major mediator

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective attenuation of metabolic branch of insulin receptor down-signaling by high glucose in a hepatoma cell line, HepG2 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic variation at the ACE gene is associated with persistent microalbuminuria and severe nephropathy in type 1 diabetes: the DCCT/EDIC Genetics Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetic nephropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The PEA15 gene is overexpressed and related to insulin resistance in healthy first-degree relatives of patients with type 2 diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transforming growth factor-beta signal transduction and progressive renal disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microalbuminuria precedes the development of NIDDM

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-beta as a key mediator

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Putative pathophysiological role of growth factors and cytokines in experimental diabetic kidney disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene and protein markers of diabetic nephropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction and intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediated apotosis in human malignant glioma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New insights into the pathophysiology of diabetic nephropathy: from haemodynamics to molecular pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microvascular disease: what does the UKPDS tell us about diabetic nephropathy?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transforming growth factor-beta and Smad signalling in kidney diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of protein kinase C activation and the vascular complications of diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated plasma levels of transforming growth factor-beta 1 in NIDDM

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endothelial alpha1-adrenoceptors regulate neo-angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Segregation analysis of diabetic nephropathy in Pima Indians

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mouse models of diabetic nephropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A primary culture of mouse proximal tubular cells, established on collagen-coated membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ameliorated glomerular injury in mice overexpressing brain natriuretic peptide with renal ablation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in plasma transforming growth factor beta in normoalbuminuric type 1 and type 2 diabetic patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of PEA-15, a major substrate for protein kinase C in astrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential role of insulin receptor substrate (IRS)-1 and IRS-2 in L6 skeletal muscle cells expressing the Arg1152 --> Gln insulin receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of protein kinase C-beta isoform in vivo reduces renal hypertrophy but not albuminuria in the streptozotocin-induced diabetic mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phorbol esters induce intracellular accumulation of the anti-apoptotic protein PED/PEA-15 by preventing ubiquitinylation and proteasomal degradation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Segregation analysis of urinary albumin excretion in families with type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19789852

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q43269412&oldid=1605916500"