Loss of Tsc1, but not Pten, in renal tubular cells causes polycystic kidney disease by activating mTORC1. (Q43289515)

18 November 2017

Loss of Tsc1, but not Pten, in renal tubular cells causes polycystic kidney disease by activating mTORC1. (English)

1 reference

polycystic kidney disease

18 November 2017

1 reference

Jing Zhou

1

1 reference

PubMed ID

19692352

18 November 2017

James Brugarolas

series ordinal

2

1 reference

PubMed ID

19692352

18 November 2017

Luis F Parada

series ordinal

3

1 reference

18 November 2017

19 August 2009

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18 November 2017

Human Molecular Genetics

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18 November 2017

18

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18 November 2017

4428-4441

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18 November 2017

22

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Dysregulation of the TSC-mTOR pathway in human disease

18 November 2017

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

TOR signaling in growth and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

mTOR, translational control and human disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Akt regulates growth by directly phosphorylating Tsc2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Renal manifestations of tuberous sclerosis complex: Incidence, prognosis, and predictive factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

A cross sectional study of renal involvement in tuberous sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Tuberous sclerosis and polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Genetics and pathogenesis of polycystic kidney disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Deletion of the TSC2 and PKD1 genes associated with severe infantile polycystic kidney disease--a contiguous gene syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Renal cystic disease in tuberous sclerosis: role of the polycystic kidney disease 1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Neuron-specific enolase-cre mouse line with cre activity in specific neuronal populations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Generalized lacZ expression with the ROSA26 Cre reporter strain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

A mouse model of tuberous sclerosis 1 showing background specific early post-natal mortality and metastatic renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Polycystic kidney disease as a result of loss of the tuberous sclerosis 2 tumor suppressor gene during development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Pten regulates neuronal arborization and social interaction in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDP398

21 January 2018

Identifiers

DOI

10.1093/HMG/DDP398

1 reference

18 November 2017

1 reference

PubMed ID

19692352