ubiquilin antagonizes presenilin and promotes neurodegeneration in Drosophila (Q43442095)

23 November 2017

ubiquilin antagonizes presenilin and promotes neurodegeneration in Drosophila (English)

1 reference

23 November 2017

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1 reference

Atish Ganguly

1

1 reference

PubMed ID

17947293

23 November 2017

R M Renny Feldman

series ordinal

2

1 reference

PubMed ID

17947293

23 November 2017

Ming Guo

series ordinal

3

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23 November 2017

18 October 2007

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23 November 2017

Human Molecular Genetics

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23 November 2017

17

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23 November 2017

2

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23 November 2017

293-302

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Reconstitution of gamma-secretase activity

23 November 2017

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

The gamma-secretase complex: machinery for intramembrane proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

New frontiers in Alzheimer's disease genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Results of a high-resolution genome screen of 437 Alzheimer's disease families

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Full genome screen for Alzheimer disease: Stage II analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Family-based association between Alzheimer's disease and variants in UBQLN1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Genetic association of ubiquilin with Alzheimer's disease and related quantitative measures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

The UBQLN1 polymorphism, UBQ-8i, at 9q22 is not associated with Alzheimer's disease with onset before 70 years.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Association study of the Ubiquilin gene with Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Interaction between presenilin 1 and ubiquilin 1 as detected by fluorescence lifetime imaging microscopy and a high-throughput fluorescent plate reader.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Overexpression of ubiquilin decreases ubiquitination and degradation of presenilin proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Transgenic Drosophila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

A reporter for amyloid precursor protein gamma-secretase activity in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Modeling clinically heterogeneous presenilin mutations with transgenic Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Presenilin is required for activity and nuclear access of Notch in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Drosophila in the study of neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Drosophila models of neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Isolation and characterization of the Drosophila ubiquilin ortholog dUbqln: in vivo interaction with early-onset Alzheimer disease genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Human neurodegenerative disease modeling using Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Caspase-dependent cell death in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Pathological and physiological functions of presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Dimerization of ubiquilin is dependent upon the central region of the protein: evidence that the monomer, but not the dimer, is involved in binding presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

A novel presenilin 1 mutation associated with Pick's disease but not beta-amyloid plaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Notch signaling: cell fate control and signal integration in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Presenilin-based genetic screens in Drosophila melanogaster identify novel notch pathway modifiers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Identification of ubiquitin-interacting proteins in purified polyglutamine aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Suppression of polyglutamine-induced toxicity in cell and animal models of Huntington's disease by ubiquilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Apoptotic activities of wild-type and Alzheimer's disease-related mutant presenilins in Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM305

21 January 2018

Identifiers

DOI

10.1093/HMG/DDM305

1 reference

23 November 2017

1 reference

PubMed ID

17947293