Phosphatidylinositol (3,4,5)P3 is essential but not sufficient for protein kinase B (PKB) activation; phosphatidylinositol (3,4)P2 is required for PKB phosphorylation at Ser-473: studies using cells from SH2-containing inositol-5-phosphatase knockou (Q43847794)

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scientific article published on 7 January 2002

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English	Phosphatidylinositol (3,4,5)P3 is essential but not sufficient for protein kinase B (PKB) activation; phosphatidylinositol (3,4)P2 is required for PKB phosphorylation at Ser-473: studies using cells from SH2-containing inositol-5-phosphatase knockou	scientific article published on 7 January 2002

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scholarly article

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5 December 2019

Phosphatidylinositol (3,4,5)P3 is essential but not sufficient for protein kinase B (PKB) activation; phosphatidylinositol (3,4)P2 is required for PKB phosphorylation at Ser-473: studies using cells from SH2-containing inositol-5-phosphatase knockout mice (English)

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5 December 2019

phosphorylation

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based on heuristic

inferred from title

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5 December 2019

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Michael P Scheid

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5 December 2019

Jacqueline E Damen

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5 December 2019

Michael Hughes

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5 December 2019

Veronica Kang

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5 December 2019

Paul Neilsen

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5 December 2019

Glenn D Prestwich

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5 December 2019

Gerald Krystal

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5 December 2019

Vincent Duronio

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7 January 2002

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5 December 2019

Journal of Biological Chemistry

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5 December 2019

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5 December 2019

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5 December 2019

9027-9035

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5 December 2019

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

SHIP, a new player in cytokine-induced signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

Targeted disruption of SHIP leads to Steel factor-induced degranulation of mast cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

The isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

Mechanism of activation and function of protein kinase B.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

Phosphatidylinositol 3-OH kinase activity is not required for activation of mitogen-activated protein kinase by cytokines

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

Multiple Cytokines Stimulate the Binding of a Common 145-Kilodalton Protein to Shc at the Grb2 Recognition Site of Shc

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

Intracellular delivery of phosphoinositides and inositol phosphates using polyamine carriers

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

c-kit receptor signaling through its phosphatidylinositide-3'-kinase-binding site and protein kinase C: role in mast cell enhancement of degranulation, adhesion, and membrane ruffling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

Identification of a second SH2-domain-containing protein closely related to the phosphatidylinositol polyphosphate 5-phosphatase SHIP

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

Biphasic activation of PKBalpha/Akt in platelets. Evidence for stimulation both by phosphatidylinositol 3,4-bisphosphate, produced via a novel pathway, and by phosphatidylinositol 3,4,5-trisphosphate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

The majority of stem cell factor exists as monomer under physiological conditions. Implications for dimerization mediating biological activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

PTEN: a tumour suppressor that functions as a phospholipid phosphatase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

Signalling through the lipid products of phosphoinositide-3-OH kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

Regulation of cell death protease caspase-9 by phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

Direct control of the Forkhead transcription factor AFX by protein kinase B

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

Phosphorylation and regulation of Raf by Akt (protein kinase B)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

Role of translocation in the activation and function of protein kinase B

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

Domain swapping used to investigate the mechanism of protein kinase B regulation by 3-phosphoinositide-dependent protein kinase 1 and Ser473 kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha) promoted by hyperosmotic stress

1 reference

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21 January 2018

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

1 reference

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21 January 2018

Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343

1 reference

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21 January 2018

The Src homology 2 (SH2) domain of SH2-containing inositol phosphatase (SHIP) is essential for tyrosine phosphorylation of SHIP, its association with Shc, and its induction of apoptosis

1 reference

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21 January 2018

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

1 reference

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21 January 2018

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106755200

21 January 2018

The inositol phosphatase SHIP inhibits Akt/PKB activation in B cells

1 reference

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21 January 2018

FcgammaRIIb modulation of surface immunoglobulin-induced Akt activation in murine B cells

1 reference

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21 January 2018

The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.

1 reference

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21 January 2018

Phosphoinositides: key players in cell signalling, in time and space.

1 reference

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21 January 2018

Lipid-Regulated Kinases: Some Common Themes at Last

1 reference

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21 January 2018

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M106755200

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11781306%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11781306%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

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