Increased 5-methylcytosine and decreased 5-hydroxymethylcytosine levels are associated with reduced striatal A2AR levels in Huntington's disease (Q43901692)

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scientific article published on 6 February 2013

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English	Increased 5-methylcytosine and decreased 5-hydroxymethylcytosine levels are associated with reduced striatal A2AR levels in Huntington's disease	scientific article published on 6 February 2013

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scholarly article

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Europe PubMed Central

PubMed publication ID

27 November 2017

Increased 5-methylcytosine and decreased 5-hydroxymethylcytosine levels are associated with reduced striatal A2AR levels in Huntington's disease (English)

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Europe PubMed Central

PubMed publication ID

27 November 2017

Huntington's disease

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Isidre Ferrer

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27 November 2017

author name string

Izaskun Villar-Menéndez

1

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27 November 2017

Marta Blanch

2

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Europe PubMed Central

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27 November 2017

Shiraz Tyebji

3

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Europe PubMed Central

PubMed publication ID

27 November 2017

Thais Pereira-Veiga

4

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Europe PubMed Central

PubMed publication ID

27 November 2017

José Luis Albasanz

5

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27 November 2017

Mairena Martín

6

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27 November 2017

Esther Pérez-Navarro

8

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27 November 2017

Marta Barrachina

9

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Europe PubMed Central

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27 November 2017

publication date

6 February 2013

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27 November 2017

NeuroMolecular Medicine

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27 November 2017

15

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27 November 2017

2

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Europe PubMed Central

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27 November 2017

295-309

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Europe PubMed Central

PubMed publication ID

27 November 2017

Activation of adenosine A2A receptors induces TrkB translocation and increases BDNF-mediated phospho-TrkB localization in lipid rafts: implications for neuromodulation

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

A pathogenic mechanism in Huntington's disease involves small CAG-repeated RNAs with neurotoxic activity.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Regional and subtype selective changes of neurotransmitter receptor density in a rat transgenic for the Huntington's disease mutation

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

DNA methylation regulates adenosine A(2A) receptor cell surface expression levels.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

DNA methylation and Yin Yang‐1 repress adenosine A2A receptor levels in human brain

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Increased adenosine A2A receptors in the brain of Parkinson's disease patients with dyskinesias

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Altered neurotransmitter receptor expression in transgenic mouse models of Huntington's disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

The A2A adenosine receptor rescues the urea cycle deficiency of Huntington's disease by enhancing the activity of the ubiquitin-proteasome system

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

cAMP-response element-binding protein contributes to suppression of the A2A adenosine receptor promoter by mutant Huntingtin with expanded polyglutamine residues

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Suppression of aggregate formation of mutant huntingtin potentiates CREB-binding protein sequestration and apoptotic cell death

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Up-regulation of striatal adenosine A(2A) receptors in schizophrenia

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

A genetic variation in the ADORA2A gene modifies age at onset in Huntington's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Brain-derived neurotrophic factor in Huntington disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Brain banks: benefits, limitations and cautions concerning the use of post-mortem brain tissue for molecular studies

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Adenosine and glutamate extracellular concentrations and mitogen-activated protein kinases in the striatum of Huntington transgenic mice. Selective antagonism of adenosine A2A receptors reduces transmitter outflow

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Increased PKA signaling disrupts recognition memory and spatial memory: role in Huntington's disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Neuronal activity modifies the DNA methylation landscape in the adult brain

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Regional and cellular gene expression changes in human Huntington's disease brain

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

A new drug design targeting the adenosinergic system for Huntington's disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Chromatin immunoprecipitation in postmortem brain

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Adenosine A2A receptor imaging with [11C]KF18446 PET in the rat brain after quinolinic acid lesion: comparison with the dopamine receptor imaging

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Genomic mapping of 5-hydroxymethylcytosine in the human brain

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Functions of DNA methylation: islands, start sites, gene bodies and beyond

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients' brains.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Interaction of Huntington disease protein with transcriptional activator Sp1

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Adenosine A2 receptors: selective localization in the human basal ganglia and alterations with disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

CpG demethylation enhances alpha-synuclein expression and affects the pathogenesis of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

A2A receptor knockout worsens survival and motor behaviour in a transgenic mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Cortical DNA methylation maintains remote memory

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Covalent modification of DNA regulates memory formation

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Adenosine A(2A) receptors measured with [C]TMSX PET in the striata of Parkinson's disease patients

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Quantification of the sixth DNA base hydroxymethylcytosine in the brain

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

5-Hydroxymethylcytosine, the sixth base of the genome

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Functional changes in postsynaptic adenosine A(2A) receptors during early stages of a rat model of Huntington disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Quantitative autoradiography of neurotransmitter receptors in Huntington disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Different methylation of the TNF-alpha promoter in cortex and substantia nigra: Implications for selective neuronal vulnerability

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Epigenetic silencing of nucleolar rRNA genes in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

A critical evaluation of adenosine A2A receptors as potentially "druggable" targets in Huntington's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Differential loss of striatal projection neurons in Huntington disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Heterogeneous dopamine receptor changes in early and late Huntington's disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

PH domain leucine-rich repeat protein phosphatase 1 contributes to maintain the activation of the PI3K/Akt pro-survival pathway in Huntington's disease striatum.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Adenosine A2A receptors and basal ganglia physiology

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Methylation status of CpG islands flanking a cAMP response element motif on the protein phosphatase 2Ac alpha promoter determines CREB binding and activity

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

DNA methylation landscapes: provocative insights from epigenomics

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Age at onset in Huntington's disease: replication study on the associations of ADORA2A, HAP1 and OGG1.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Role of adenosine A(2A) receptors in modulating synaptic functions and brain levels of BDNF: a possible key mechanism in the pathophysiology of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2).

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

-Aminobutyric acid receptors in normal human brain and Huntington disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Biological abnormalities of peripheral A(2A) receptors in a large representation of polyglutamine disorders and Huntington's disease stages

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

A2A adenosine receptor overexpression and functionality, as well as TNF-alpha levels, correlate with motor symptoms in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Huntington disease models and human neuropathology: similarities and differences

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Neurotransmitter receptor alterations in Huntington's disease: autoradiographic and homogenate studies with special reference to benzodiazepine receptor complexes

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Role of CpG context and content in evolutionary signatures of brain DNA methylation.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Dynamic changes in DNA methylation during thermal control establishment affect CREB binding to the brain-derived neurotrophic factor promoter.

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

NMDA receptor losses in putamen from patients with Huntington's disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Characterization of genomic organization of the adenosine A2A receptor gene by molecular and bioinformatics analyses

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Huntingtin inclusions do not deplete polyglutamine-containing transcription factors in HD mice

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington's disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

A DNA Methylation Study of the Amyloid Precursor Protein Gene in Several Brain Regions from Patients with Familial Alzheimer Disease

1 reference

https://api.crossref.org/works/10.1007%2FS12017-013-8219-0

21 January 2018

Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23385980

12 December 2020

based on heuristic

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Blockade of striatal adenosine A2A receptor reduces, through a presynaptic mechanism, quinolinic acid-induced excitotoxicity: possible relevance to neuroprotective interventions in neurodegenerative diseases of the striatum.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23385980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A dual role of adenosine A2A receptors in 3-nitropropionic acid-induced striatal lesions: implications for the neuroprotective potential of A2A antagonists.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23385980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropathological classification of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23385980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/23385980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased receptor-binding sites for kainic acid in brains of patients with Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23385980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant huntingtin represses CBP, but not p300, by binding and protein degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23385980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Next-generation sequencing reveals regional differences of the α-synuclein methylation state independent of Lewy body disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23385980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S12017-013-8219-0

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

ResearchGate publication ID

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