Caspase-9 and Apaf-1 are expressed and functionally active in human neuroblastoma tumor cell lines with 1p36 LOH and amplified MYCN. (Q43919094)

28 November 2017

Caspase-9 and Apaf-1 are expressed and functionally active in human neuroblastoma tumor cell lines with 1p36 LOH and amplified MYCN. (English)

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28 November 2017

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Tal Teitz

1

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28 November 2017

Tie Wei

2

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28 November 2017

Dong Liu

3

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28 November 2017

Virginia Valentine

4

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28 November 2017

Marcus Valentine

5

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28 November 2017

Jose Grenet

6

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28 November 2017

Jill M Lahti

7

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28 November 2017

Vincent J Kidd

8

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28 November 2017

language of work or name

English

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publication date

1 March 2002

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28 November 2017

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28 November 2017

21

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28 November 2017

12

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28 November 2017

1848-1858

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205180

28 November 2017

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Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death

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Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria

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Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c.

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Double identity for proteins of the Bcl-2 family

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Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation

21 January 2018

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FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b.

21 January 2018

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p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release.

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Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cells

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Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

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Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

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Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis

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7 January 2021

Allelic loss of chromosome 1 and additional chromosome 17 material are both unfavourable prognostic markers in neuroblastoma

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7 January 2021

Allelic loss of chromosome 1p36 in neuroblastoma is of preferential maternal origin and correlates with N-myc amplification

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7 January 2021

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

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7 January 2021

Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis

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7 January 2021

Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis

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7 January 2021

Cleavage of poly(ADP-ribose) polymerase by interleukin-1 beta converting enzyme and its homologs TX and Nedd-2

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7 January 2021

Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c rel

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7 January 2021

Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205180

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205180

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Dimensions Publication ID

28 November 2017

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