Insulin restores differentiation of Ras-transformed C2C12 myoblasts by inducing NF-kappaB through an AKT/P70S6K/p38-MAPK pathway (Q44007852)

28 November 2017

title

Insulin restores differentiation of Ras-transformed C2C12 myoblasts by inducing NF-kappaB through an AKT/P70S6K/p38-MAPK pathway (English)

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28 November 2017

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Ruben Conejo

1

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28 November 2017

Cristina de Alvaro

2

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28 November 2017

Manuel Benito

3

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28 November 2017

Antonio Cuadrado

4

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28 November 2017

Margarita Lorenzo

5

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28 November 2017

language of work or name

English

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publication date

1 May 2002

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28 November 2017

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28 November 2017

volume

21

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28 November 2017

issue

23

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28 November 2017

page(s)

3739-3753

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PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

28 November 2017

cites work

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7 January 2021

Roles of insulin-like growth factor (IGF) receptors and IGF-binding proteins in IGF-II-induced proliferation and differentiation of L6A1 rat myoblasts

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Regulation of distinct stages of skeletal muscle differentiation by mitogen-activated protein kinases

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7 January 2021

Insulin antiapoptotic signaling involves insulin activation of the nuclear factor kappaB-dependent survival genes encoding tumor necrosis factor receptor-associated factor 2 and manganese-superoxide dismutase.

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7 January 2021

Cloning and characterization of a cDNA encoding the rat brain glucose-transporter protein

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7 January 2021

Plasticity of the differentiated state

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7 January 2021

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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7 January 2021

Nuclear factor kappa B-inducing kinase and Ikappa B kinase-alpha signal skeletal muscle cell differentiation

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7 January 2021

Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes

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7 January 2021

Insulin signaling leading to proliferation, survival, and membrane ruffling in C2C12 myoblasts

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7 January 2021

Insulin produces myogenesis in C2C12 myoblasts by induction of NF-kappaB and downregulation of AP-1 activities

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7 January 2021

The mitogenic and myogenic actions of insulin-like growth factors utilize distinct signaling pathways.

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7 January 2021

Stress-activated protein kinase-2/p38 and a rapamycin-sensitive pathway are required for C2C12 myogenesis

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7 January 2021

Activated Raf inhibits avian myogenesis through a MAPK-dependent mechanism.

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7 January 2021

IGF-II is more active than IGF-I in stimulating L6A1 myogenesis: greater mitogenic actions of IGF-I delay differentiation

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7 January 2021

Activation of p70s6k is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifs

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7 January 2021

Targeted down-regulation of caveolin-3 is sufficient to inhibit myotube formation in differentiating C2C12 myoblasts. Transient activation of p38 mitogen-activated protein kinase is required for induction of caveolin-3 expression and subsequent myot

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7 January 2021

Mutational status of K-ras and TP53 genes in primary sarcomas of the heart

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7 January 2021

Monoglucosylation of RhoA at threonine 37 blocks cytosol-membrane cycling

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7 January 2021

Mitogen-activated protein kinase pathway is involved in the differentiation of muscle cells

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7 January 2021

NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1.

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7 January 2021

Insulin-like growth factors require phosphatidylinositol 3-kinase to signal myogenesis: dominant negative p85 expression blocks differentiation of L6E9 muscle cells

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7 January 2021

Insulin-like growth factor-II, phosphatidylinositol 3-kinase, nuclear factor-kappaB and inducible nitric-oxide synthase define a common myogenic signaling pathway

1 reference

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7 January 2021

Phosphatidylinositol 3-kinase inhibitors block differentiation of skeletal muscle cells

1 reference

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7 January 2021

The regulation of AP-1 activity by mitogen-activated protein kinases

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7 January 2021

Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase

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7 January 2021

A simple, rapid, and sensitive DNA assay procedure

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7 January 2021

The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205469

7 January 2021

Transformation by activated ras or fos prevents myogenesis by inhibiting expression of MyoD1.

1 reference

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7 January 2021

NF-kappaB-dependent expression of nitric oxide synthase is required for membrane fusion of chick embryonic myoblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205469

7 January 2021

Simultaneous analysis of immunophenotype and apoptosis of murine thymocytes by single laser flow cytometry

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205469

7 January 2021

Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205469

7 January 2021

Differential effects of Ras signaling through NFkappaB on skeletal myogenesis

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205469

7 January 2021

Activation of Akt during simulated ischemia/reperfusion in cardiac myocytes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205469

7 January 2021

Insulin/IGF-I rescues immortalized brown adipocytes from apoptosis down-regulating Bcl-xS expression, in a PI 3-kinase- and map kinase-dependent manner

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205469

7 January 2021

Activated Ha-ras induces apoptosis by association with phosphorylated Bcl-2 in a mitogen-activated protein kinase-independent manner.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205469

7 January 2021

The oncogenic forms of N-ras or H-ras prevent skeletal myoblast differentiation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205469

7 January 2021

Phosphatidylinositol-3-OH kinase as a direct target of Ras

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205469

7 January 2021

Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205469

7 January 2021

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205469

7 January 2021

Akt1/PKBalpha protects PC12 cells against the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium and reduces the levels of oxygen-free radicals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205469

7 January 2021

Extracellular signal-regulated kinase-1 and -2 respond differently to mitogenic and differentiative signaling pathways in myoblasts

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205469

7 January 2021

Three different fibronectin mRNAs arise by alternative splicing within the coding region

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205469

7 January 2021

Positive regulation of skeletal myogenesis by R-Ras

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205469

7 January 2021

Roles of NF-kappaB and 26 S proteasome in apoptotic cell death induced by topoisomerase I and II poisons in human nonsmall cell lung carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205469

7 January 2021

Signals from the Ras, Rac, and Rho GTPases converge on the Pak protein kinase in Rat-1 fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205469

7 January 2021

Inhibitors of oxidative stress mimic the ability of follicle-stimulating hormone to suppress apoptosis in cultured rat ovarian follicles

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205469

7 January 2021

Insulin activates a p21-activated kinase in muscle cells via phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205469

7 January 2021

Phosphatidylinositol 3-kinase is a requirement for insulin-like growth factor I-induced differentiation, but not for mitogenesis, in fetal brown adipocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205469

7 January 2021

The molecular biology of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205469

7 January 2021

Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205469

7 January 2021

The MyoD family and myogenesis: redundancy, networks, and thresholds

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205469

7 January 2021

Distinct signaling pathways regulate transformation and inhibition of skeletal muscle differentiation by oncogenic Ras

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205469

7 January 2021

Mitogen-activated protein kinase kinase (MEK) activity is required for inhibition of skeletal muscle differentiation by insulin-like growth factor 1 or fibroblast growth factor 2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205469

7 January 2021

The isoform-specific stretch of hSos1 defines a new Grb2-binding domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205469

7 January 2021

p38 mitogen-activated protein kinase pathway promotes skeletal muscle differentiation. Participation of the Mef2c transcription factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205469

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205469

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Dimensions Publication ID

28 November 2017

1003251052

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1 reference