The N-terminal SH2 domains of Syk and ZAP-70 mediate phosphotyrosine-independent binding to integrin beta cytoplasmic domains. (Q44097443)

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11 November 2019

title

The N-terminal SH2 domains of Syk and ZAP-70 mediate phosphotyrosine-independent binding to integrin beta cytoplasmic domains (English)

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11 November 2019

3

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11 November 2019

author name string

Darren G Woodside

1

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11 November 2019

Achim Obergfell

2

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11 November 2019

David A Calderwood

4

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11 November 2019

Sanford J Shattil

5

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11 November 2019

Mark H Ginsberg

6

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11 November 2019

language of work or name

English

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publication date

8 August 2002

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Journal of Biological Chemistry

11 November 2019

published in

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11 November 2019

volume

277

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11 November 2019

issue

42

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11 November 2019

page(s)

39401-39408

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Integrins: versatility, modulation, and signaling in cell adhesion

11 November 2019

cites work

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Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells. A possible signaling role for the Syk tyrosine kinase.

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Activation of Syk protein tyrosine kinase through interaction with integrin beta cytoplasmic domains

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Syk is required for integrin signaling in neutrophils

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The Syk family of protein tyrosine kinases in T-cell activation and development

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Syk tyrosine kinase is required for the positive selection of immature B cells into the recirculating B cell pool

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Syk tyrosine kinase required for mouse viability and B-cell development

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Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck

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Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product

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Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase

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Identification of shc as the primary protein binding to the tyrosine-phosphorylated beta 3 subunit of alpha IIbbeta 3 during outside-in integrin platelet signaling

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Breaking the integrin hinge. A defined structural constraint regulates integrin signaling

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Interaction of p72syk with the gamma and beta subunits of the high-affinity receptor for immunoglobulin E, Fc epsilon RI

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The molecular adapter SLP-76 relays signals from platelet integrin alphaIIbbeta3 to the actin cytoskeleton.

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Integrin beta cytoplasmic domains differentially bind to cytoskeletal proteins.

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Calpain cleavage promotes talin binding to the beta 3 integrin cytoplasmic domain

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ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency

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Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase

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Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide

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Integrin cytoplasmic tyrosine motif is required for outside-in alphaIIbbeta3 signalling and platelet function

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ZAP-70 tyrosine kinase is required for LFA-1-dependent T cell migration

21 January 2018

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The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM

21 January 2018

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Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition

21 January 2018

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Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A

21 January 2018

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A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome

21 January 2018

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21 January 2018

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Syk is activated by phosphotyrosine-containing peptides representing the tyrosine-based activation motifs of the high affinity receptor for IgE.

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Identification of talin as a major cytoplasmic protein implicated in platelet activation

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21 January 2018

Identifiers

DOI

10.1074/JBC.M207657200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12171941%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

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