Molecular evolution of Keap1. Two Keap1 molecules with distinctive intervening region structures are conserved among fish (Q44138968)

30 November 2017

Molecular evolution of Keap1. Two Keap1 molecules with distinctive intervening region structures are conserved among fish (English)

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Kelch-like ECH-associated protein 1a

30 November 2017

1 reference

GOA release 2020-03-11

author name string

Li Li

1

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30 November 2017

Makoto Kobayashi

2

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30 November 2017

Hiroshi Kaneko

3

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30 November 2017

Yaeko Nakajima-Takagi

4

1 reference

30 November 2017

Yuko Nakayama

5

1 reference

30 November 2017

Masayuki Yamamoto

6

1 reference

30 November 2017

language of work or name

English

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publication date

5 December 2007

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Journal of Biological Chemistry

30 November 2017

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30 November 2017

283

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30 November 2017

6

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30 November 2017

3248-3255

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Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species

30 November 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

MafT, a new member of the small Maf protein family in zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

The LN54 radiation hybrid map of zebrafish expressed sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

Characterization of the murine mafF gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

The homeobox protein Six3 interacts with the Groucho corepressor and acts as a transcriptional repressor in eye and forebrain formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

Molecular phylogeny of the kelch-repeat superfamily reveals an expansion of BTB/kelch proteins in animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

Pi class glutathione S-transferase genes are regulated by Nrf 2 through an evolutionarily conserved regulatory element in zebrafish.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

The BACK domain in BTB-kelch proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

Zebrafish hox clusters and vertebrate genome evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708702200

21 January 2018

Identifiers

DOI

10.1074/JBC.M708702200

1 reference

30 November 2017

1 reference