Regulation of intracellular pH mediates Bax activation in HeLa cells treated with staurosporine or tumor necrosis factor-alpha (Q44189931)

30 November 2017

title

Regulation of intracellular pH mediates Bax activation in HeLa cells treated with staurosporine or tumor necrosis factor-alpha (English)

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30 November 2017

Joshua A Cohn

2

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author name string

Marco Tafani

1

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30 November 2017

Natalie O Karpinich

3

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30 November 2017

Ronald J Rothman

4

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30 November 2017

Matteo A Russo

5

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30 November 2017

John L Farber

6

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30 November 2017

language of work or name

English

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publication date

18 October 2002

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Journal of Biological Chemistry

30 November 2017

published in

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30 November 2017

volume

277

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30 November 2017

issue

51

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30 November 2017

page(s)

49569-49576

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Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

30 November 2017

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Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

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Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

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Conformation of the Bax C-terminus regulates subcellular location and cell death

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Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH.

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21 January 2018

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21 January 2018

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Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death

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21 January 2018

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21 January 2018

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21 January 2018

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A serine residue in ClC-3 links phosphorylation-dephosphorylation to chloride channel regulation by cell volume

21 January 2018

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Tyrosine kinase-dependent activation of a chloride channel in CD95-induced apoptosis in T lymphocytes.

21 January 2018

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Activation of potassium and chloride channels by tumor necrosis factor alpha. Role in liver cell death

21 January 2018

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Intracellular pH regulation in epithelial cells

21 January 2018

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The cytotoxicity of tumor necrosis factor depends on induction of the mitochondrial permeability transition

21 January 2018

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Cytochrome c-dependent activation of caspase-3 by tumor necrosis factor requires induction of the mitochondrial permeability transition

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M208915200

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30 November 2017

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