The fragile X mental retardation protein FMRP binds elongation factor 1A mRNA and negatively regulates its translation in vivo (Q44320733)

1 December 2017

The fragile X mental retardation protein FMRP binds elongation factor 1A mRNA and negatively regulates its translation in vivo (English)

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1 December 2017

Ying Ju Sung

1

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1 December 2017

Natalia Dolzhanskaya

2

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1 December 2017

Sarah L Nolin

3

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1 December 2017

Ted Brown

4

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1 December 2017

Julia R Currie

5

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1 December 2017

Robert B Denman

6

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1 December 2017

language of work or name

English

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publication date

19 February 2003

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Journal of Biological Chemistry

1 December 2017

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1 December 2017

278

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1 December 2017

18

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1 December 2017

15669-15678

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RNAs that interact with the fragile X syndrome RNA binding protein FMRP.

1 December 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

Essential role for KH domains in RNA binding: impaired RNA binding by a mutation in the KH domain of FMR1 that causes fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M211117200

Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M211117200

The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

The fragile X mental retardation protein is associated with poly(A)+ mRNA in actively translating polyribosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

FMR1 protein: conserved RNP family domains and selective RNA binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

A decade of molecular studies of fragile X syndrome

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M211117200

The fragile X mental retardation protein inhibits translation via interacting with mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

Evidence that fragile X mental retardation protein is a negative regulator of translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

Species-specific and isoform-specific RNA binding of human and mouse fragile X mental retardation proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

Measurement of protein using bicinchoninic acid

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M211117200

Self-cleaving-ribozyme-mediated reduction of betaAPP in human rhabdomyosarcoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

Distribution and activity of alternatively spliced alzheimer amyloid peptide precursor and scrapie PrP mRNAs on rat brain polysomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

Ribozyme and antisense RNAs inhibit coupled transcription translation by binding to rabbit polyribosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

The fragile X mental retardation protein is associated with ribosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

Purified recombinant Fmrp exhibits selective RNA binding as an intrinsic property of the fragile X mental retardation protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

Sequence-specific RNA binding by a Nova KH domain: implications for paraneoplastic disease and the fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

Purification and properties of HuD, a neuronal RNA-binding protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

Differential activity of trans-acting hammerhead ribozymes targeted to beta amyloid peptide precursor mRNA by altering the symmetry of helices I and III.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

A point mutation in the FMR-1 gene associated with fragile X mental retardation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

Trapping of messenger RNA by Fragile X Mental Retardation protein into cytoplasmic granules induces translation repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

Identification of mouse YB1/p50 as a component of the FMRP-associated mRNP particle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

Identification of mRNA/protein (mRNP) complexes containing Puralpha, mStaufen, fragile X protein, and myosin Va and their association with rough endoplasmic reticulum equipped with a kinesin motor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

KH domains within the FMR1 sequence suggest that fragile X syndrome stems from a defect in RNA metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

Understanding the molecular basis of fragile X syndrome

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M211117200

Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

Biomedicine. Do G quartets orchestrate fragile X pathology?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

Expression of FMR1, FXR1, and FXR2 genes in human prenatal tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

Reduced cortical synaptic plasticity and GluR1 expression associated with fragile X mental retardation protein deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

Tissue-dependent variation in the expression of elongation factor-1 alpha isoforms: isolation and characterisation of a cDNA encoding a novel variant of human elongation-factor 1 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

Cloning of human and mouse brain cDNAs coding for S1, the second member of the mammalian elongation factor-1 alpha gene family: analysis of a possible evolutionary pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

Elongation factor EF-1 alpha gene dosage alters translational fidelity in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficits

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

Increased density of multiple-head dendritic spines on medium-sized spiny neurons of the striatum in rats reared in a complex environment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

Dendritic spine structural anomalies in fragile-X mental retardation syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211117200

21 January 2018

Identifiers

DOI

10.1074/JBC.M211117200

1 reference

1 December 2017

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