Identification of two reactive cysteine residues in the tumor suppressor protein p53 using top-down FTICR mass spectrometry (Q44483891)

3 December 2017

Identification of two reactive cysteine residues in the tumor suppressor protein p53 using top-down FTICR mass spectrometry (English)

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3 December 2017

David J Clarke

2

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author name string

Jenna Scotcher

1

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3 December 2017

Stefan K Weidt

3

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3 December 2017

C Logan Mackay

4

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3 December 2017

Ted R Hupp

5

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3 December 2017

Peter J Sadler

6

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3 December 2017

Pat R R Langridge-Smith

7

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3 December 2017

24 February 2011

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Journal of the American Society for Mass Spectrometry

3 December 2017

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3 December 2017

22

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3 December 2017

5

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3 December 2017

888-897

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https://scigraph.springernature.com/pub.10.1007/s13361-011-0088-x

3 December 2017

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p53 in health and disease

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Structural biology of the tumor suppressor p53.

21 January 2018

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Complicating the complexity of p53

21 January 2018

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Differential regulation of p53 target genes: it's (core promoter) elementary.

21 January 2018

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Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

21 January 2018

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Characterization of baculovirus recombinant wild-type p53. Dimerization of p53 is required for high-affinity DNA binding and cysteine oxidation inhibits p53 DNA binding

21 January 2018

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Formation of Disulfide Bond in p53 Correlates with Inhibition of DNA Binding and Tetramerization

21 January 2018

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Redox state regulates binding of p53 to sequence-specific DNA, but not to non-specific or mismatched DNA.

21 January 2018

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Redox state of tumor suppressor p53 regulates its sequence-specific DNA binding in DNA-damaged cells by cysteine 277

21 January 2018

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Role of cysteine residues in regulation of p53 function

21 January 2018

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A role for DNA-mediated charge transport in regulating p53: Oxidation of the DNA-bound protein from a distance

21 January 2018

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Pyrrolidine dithiocarbamate prevents p53 activation and promotes p53 cysteine residue oxidation.

21 January 2018

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Selenomethionine regulation of p53 by a ref1-dependent redox mechanism

21 January 2018

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Targeted quantitation of site-specific cysteine oxidation in endogenous proteins using a differential alkylation and multiple reaction monitoring mass spectrometry approach

21 January 2018

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Zinc binding and redox control of p53 structure and function.

21 January 2018

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Effect of thioredoxin deletion and p53 cysteine replacement on human p53 activity in wild-type and thioredoxin reductase null yeast

21 January 2018

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ROS and p53: a versatile partnership

21 January 2018

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Redox signalling and transition metals in the control of the p53 pathway

21 January 2018

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Mutant p53 rescue and modulation of p53 redox state.

21 January 2018

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PRIMA-1 reactivates mutant p53 by covalent binding to the core domain

21 January 2018

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Fourier transform ion cyclotron resonance mass spectrometry: a primer

21 January 2018

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Electron Capture Dissociation of Multiply Charged Protein Cations. A Nonergodic Process

21 January 2018

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Decoding protein modifications using top-down mass spectrometry

21 January 2018

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Proteomics by FTICR mass spectrometry: top down and bottom up

21 January 2018

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Detection and localization of protein modifications by high resolution tandem mass spectrometry

21 January 2018

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Thiol alkylation inhibits the mitogenic effects of platelet-derived growth factor and renders it proapoptotic via activation of STATs and p53 and induction of expression of caspase1 and p21(waf1/cip1).

21 January 2018

1 reference

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Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs.

21 January 2018

1 reference

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The p73 DNA binding domain displays enhanced stability relative to its homologue, the tumor suppressor p53, and exhibits cooperative DNA binding.

21 January 2018

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Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax.

21 January 2018

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Thermodynamic stability of wild-type and mutant p53 core domain

21 January 2018

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Quantitative analysis of modified proteins and their positional isomers by tandem mass spectrometry: human histone H4.

21 January 2018

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ProSight PTM: an integrated environment for protein identification and characterization by top-down mass spectrometry

21 January 2018

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Structure, function, and aggregation of the zinc-free form of the p53 DNA binding domain

21 January 2018

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Effects of stability on the biological function of p53.

21 January 2018

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Tandem mass spectrometry with ultrahigh mass accuracy clarifies peptide identification by database retrieval

21 January 2018

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Structure of the human p53 core domain in the absence of DNA

21 January 2018

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Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations

21 January 2018

1 reference

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Human p53 is inhibited by glutathionylation of cysteines present in the proximal DNA-binding domain during oxidative stress.

21 January 2018

1 reference

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Apoptosis - the p53 network

21 January 2018

1 reference

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15-Deoxy-Delta(12,14)-prostaglandin J(2) stabilizes, but functionally inactivates p53 by binding to the cysteine 277 residue

21 January 2018

1 reference

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The MDM2 ubiquitination signal in the DNA-binding domain of p53 forms a docking site for calcium calmodulin kinase superfamily members

21 January 2018

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ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis

21 January 2018

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Kinetic Instability of p53 Core Domain Mutants

21 January 2018

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Stabilization of mutant p53 via alkylation of cysteines and effects on DNA binding

21 January 2018

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12 December 2020

1 reference

12 December 2020

Electron capture dissociation for structural characterization of multiply charged protein cations

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12 December 2020

The conserved redox-sensitive cysteine residue of the DNA-binding region in the c-Rel protein is involved in the regulation of the phosphorylation of the protein

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12 December 2020

Metalloregulation of the tumor suppressor protein p53: zinc mediates the renaturation of p53 after exposure to metal chelators in vitro and in intact cells

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12 December 2020

Collision-induced dissociation (CID) of peptides and proteins

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12 December 2020

Structural aspects of the p53 protein in relation to gene evolution

1 reference

12 December 2020

10.1007/S13361-011-0088-X

Identifiers

DOI

1 reference

3 December 2017

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