Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs. (Q40401654)

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13 January 2020

title

Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs (English)

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13 January 2020

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7

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Klas Wiman

8

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1

Vladimir J N Bykov

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2

Natalia Issaeva

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4

Alexandre Shilov

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13 January 2020

author name string

Nicole Zache

3

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Monica Hultcrantz

5

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Jan Bergman

6

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13 January 2020

language of work or name

English

0 references

publication date

1 July 2005

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Journal of Biological Chemistry

13 January 2020

number of pages

8

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based on heuristic

inferred from page(s)

published in

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volume

280

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issue

34

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page(s)

30384-30391

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cites work

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p53 mutations in human cancers

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Rescuing the function of mutant p53.

21 January 2018

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Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

21 January 2018

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The ubiquitin ligase COP1 is a critical negative regulator of p53

21 January 2018

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Small molecules that reactivate mutant p53.

21 January 2018

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Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations

21 January 2018

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Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

21 January 2018

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Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

21 January 2018

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Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database.

21 January 2018

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Redox control of cell death

21 January 2018

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Redox state of tumor suppressor p53 regulates its sequence-specific DNA binding in DNA-damaged cells by cysteine 277

21 January 2018

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Zinc binding and redox control of p53 structure and function.

21 January 2018

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Restoration of wild-type conformation and activity of a temperature-sensitive mutant of p53 (p53(V272M)) by the cytoprotective aminothiol WR1065 in the esophageal cancer cell line TE-1.

21 January 2018

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Activation of p53 by the cytoprotective aminothiol WR1065: DNA-damage-independent pathway and redox-dependent modulation of p53 DNA-binding activity.

21 January 2018

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Selenomethionine regulation of p53 by a ref1-dependent redox mechanism

21 January 2018

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Formation of Disulfide Bond in p53 Correlates with Inhibition of DNA Binding and Tetramerization

21 January 2018

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Role of cysteine residues in regulation of p53 function

21 January 2018

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Thiol alkylation inhibits the mitogenic effects of platelet-derived growth factor and renders it proapoptotic via activation of STATs and p53 and induction of expression of caspase1 and p21(waf1/cip1).

21 January 2018

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Glutathione analogues in cancer treatment

21 January 2018

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GSH depletion enhances adenoviral bax-induced apoptosis in lung cancer cells.

21 January 2018

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Thiol oxidation enforces phosphatidylserine externalization in apoptosis-sensitive and -resistant cells through a deltapsim/cytochrome C release-dependent mechanism

21 January 2018

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In vitro antitumor and antimicrobial activities of N-substituents of maleimide by adamantane and diamantane.

21 January 2018

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Dimethyladamantylmaleimide-induced in vitro and in vivo growth inhibition of human colon cancer Colo205 cells

21 January 2018

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The single-stranded DNA end binding site of p53 coincides with the C-terminal regulatory region.

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M501664200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15998635%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

1 reference