Caffeine inhibits checkpoint responses without inhibiting the ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinases (Q44504054)

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scientific article published on 7 July 2003

Language	Label	Description	Also known as
English	Caffeine inhibits checkpoint responses without inhibiting the ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinases	scientific article published on 7 July 2003

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scholarly article

1 reference

Europe PubMed Central

3 December 2017

Caffeine inhibits checkpoint responses without inhibiting the ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinases (English)

1 reference

Europe PubMed Central

3 December 2017

author name string

David Cortez

1

1 reference

Europe PubMed Central

3 December 2017

language of work or name

0 references

publication date

7 July 2003

1 reference

Europe PubMed Central

3 December 2017

Journal of Biological Chemistry

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Europe PubMed Central

3 December 2017

278

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Europe PubMed Central

3 December 2017

39

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Europe PubMed Central

3 December 2017

37139-37145

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Europe PubMed Central

3 December 2017

ATM and ATR: networking cellular responses to DNA damage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Cell cycle checkpoint signaling through the ATM and ATR kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

ATR and ATRIP: partners in checkpoint signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Enhanced phosphorylation of p53 by ATM in response to DNA damage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

ATR Regulates Fragile Site Stability

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Caffeine mimics adenine and 2′‐deoxyadenosine, both of which inhibit the guanine‐nucleotide exchange activity of RCC1 and the kinase activity of ATR

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Induction of alkaline phosphatase activity in HeLa cells. Inhibition by xanthine derivatives and thermostability studies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Mechanism by which caffeine potentiates lethality of nitrogen mustard

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Caffeine inhibits the checkpoint kinase ATM

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Cell cycle control and cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Toward maintaining the genome: DNA damage and replication checkpoints

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Detection of ATM gene mutation in human glioma cell line M059J by a rapid frameshift/stop codon assay in yeast.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

ATP activates ataxia-telangiectasia mutated (ATM) in vitro. Importance of autophosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Molecular mechanisms of DNA repair inhibition by caffeine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Methylxanthine inhibitors of phosphodiesterases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Selective radiosensitization of p53-deficient cells by caffeine-mediated activation of p34cdc2 kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Effect of poly(adenosinediphosphoribose) synthesis inhibitors and structurally related compounds on radiation-induced G2 arrest

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

The Interaction of Caffeine with Ultra-violet-light-irradiated DNA

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Studies on DNA binding of caffeine and derivatives: evidence of intercalation by DNA-unwinding experiments

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307088200

21 January 2018

Identifiers

10.1074/JBC.M307088200

1 reference

Europe PubMed Central

3 December 2017

1 reference

Europe PubMed Central

3 December 2017

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