sst2 Somatostatin receptor inhibits cell proliferation through Ras-, Rap1-, and B-Raf-dependent ERK2 activation (Q44524136)

3 December 2017

sst2 Somatostatin receptor inhibits cell proliferation through Ras-, Rap1-, and B-Raf-dependent ERK2 activation (English)

1 reference

3 December 2017

Hicham Lahlou

1

1 reference

3 December 2017

Nathalie Saint-Laurent

2

1 reference

3 December 2017

Jean-Pierre Estève

3

1 reference

3 December 2017

Alain Eychène

4

1 reference

3 December 2017

Lucien Pradayrol

5

1 reference

3 December 2017

Stéphane Pyronnet

6

1 reference

3 December 2017

Christiane Susini

7

1 reference

3 December 2017

language of work or name

English

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publication date

22 July 2003

1 reference

Journal of Biological Chemistry

3 December 2017

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3 December 2017

278

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3 December 2017

41

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3 December 2017

39356-39371

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Somatostatin and its receptor family

3 December 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Mechanisms of antineoplastic action of somatostatin analogs

21 January 2018

1 reference

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Inhibition of cell proliferation by the somatostatin analogue RC-160 is mediated by somatostatin receptor subtypes SSTR2 and SSTR5 through different mechanisms

21 January 2018

1 reference

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Inhibition of growth and metastatic progression of pancreatic carcinoma in hamster after somatostatin receptor subtype 2 (sst2) gene expression and administration of cytotoxic somatostatin analog AN-238.

21 January 2018

1 reference

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New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

High intensity ERK signal mediates hepatocyte growth factor-induced proliferation inhibition of the human hepatocellular carcinoma cell line HepG2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

The cyclic adenosine monophosphate-dependent protein kinase (PKA) is required for the sustained activation of mitogen-activated kinases and gene expression by nerve growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Role of Ras and Mapks in TGFbeta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Untying the regulation of the Raf-1 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

The Raf/MEK/ERK pathway: new concepts of activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Rap1 signalling: adhering to new models

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

The strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of Raf to Ras family small GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Characterization of the antiproliferative signal mediated by the somatostatin receptor subtype sst5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Selective stimulation of somatostatin receptor subtypes: differential effects on Ras/MAP kinase pathway and cell proliferation in human neuroblastoma cells

21 January 2018

1 reference

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Influence of the somatostatin receptor sst2 on growth factor signal cascades in human glioma cells

21 January 2018

1 reference

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Receptor isoforms mediate opposing proliferative effects through gbetagamma-activated p38 or Akt pathways

21 January 2018

1 reference

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Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene.

21 January 2018

1 reference

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Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Neuronal nitric oxide synthase: a substrate for SHP-1 involved in sst2 somatostatin receptor growth inhibitory signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

sst2 somatostatin receptor mediates negative regulation of insulin receptor signaling through the tyrosine phosphatase SHP-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Thrombopoietin-mediated sustained activation of extracellular signal-regulated kinase in UT7-Mpl cells requires both Ras-Raf-1- and Rap1-B-Raf-dependent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

The requirement of specific membrane domains for Raf-1 phosphorylation and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Somatostatin receptor activation of cellular effector systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

The tyrosine phosphatase SHP-1 associates with the sst2 somatostatin receptor and is an essential component of sst2-mediated inhibitory growth signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Novel regulation and function of Src tyrosine kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Assembly and function of a cytosolic form of NADH-specific isocitrate dehydrogenase in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Alpha-adrenergic inhibition of proliferation in HepG2 cells stably transfected with the alpha1B-adrenergic receptor through a p42MAPkinase/p21Cip1/WAF1-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Cyclins D1 and D2 mediate myc-induced proliferation via sequestration of p27(Kip1) and p21(Cip1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Differential regulation of p27(Kip1) expression by mitogenic and hypertrophic factors: Involvement of transcriptional and posttranscriptional mechanisms

21 January 2018

1 reference

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Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Requirement of p38 mitogen-activated protein kinase for neuronal differentiation in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Senescence of human fibroblasts induced by oncogenic Raf.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Activated Raf-1 causes growth arrest in human small cell lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Cellular response to oncogenic ras involves induction of the Cdk4 and Cdk6 inhibitor p15(INK4b)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Cyclic AMP-independent involvement of Rap1/B-Raf in the angiotensin II AT2 receptor signaling pathway in NG108-15 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Activation of B-Raf and regulation of the mitogen-activated protein kinase pathway by the G(o) alpha chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Galpha and Gbeta gamma require distinct Src-dependent pathways to activate Rap1 and Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Phosphoinositide 3-kinase-dependent regulation of interleukin-3-induced proliferation: involvement of mitogen-activated protein kinases, SHP2 and Gab2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Activation of Rap1B by G(i) family members in platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Phosphotyrosine 1173 mediates binding of the protein-tyrosine phosphatase SHP-1 to the epidermal growth factor receptor and attenuation of receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

Pivotal role of tyrosine phosphatase SHP-1 in AT2 receptor-mediated apoptosis in rat fetal vascular smooth muscle cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M304524200

21 January 2018

Identifiers

DOI

10.1074/JBC.M304524200

1 reference

3 December 2017

1 reference