Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. (Q44532915)

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6 November 2019

title

Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration (English)

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6 November 2019

9

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6 November 2019

Takafumi Uchida

7

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6 November 2019

author name string

Yih-Cherng Liou

1

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6 November 2019

Anyang Sun

2

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6 November 2019

Akihide Ryo

3

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6 November 2019

Xiao Zhen Zhou

4

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6 November 2019

Zhao-Xue Yu

5

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6 November 2019

Han-Kuei Huang

6

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6 November 2019

Roderick Bronson

8

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6 November 2019

Xiaojiang Li

10

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6 November 2019

Tony Hunter

11

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6 November 2019

Kun Ping Lu

12

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6 November 2019

language of work or name

English

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publication date

1 July 2003

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6 November 2019

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6 November 2019

volume

424

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6 November 2019

page(s)

556-561

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6 November 2019

issue

6948

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https://scigraph.springernature.com/pub.10.1038/nature01832

6 November 2019

exact match

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Mitotic phosphorylation of tau protein in neuronal cell lines resembles phosphorylation in Alzheimer's disease.

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Mitotic phosphoepitopes precede paired helical filaments in Alzheimer's disease

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Proline-directed phosphorylation and isomerization in mitotic regulation and in Alzheimer's Disease

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A human peptidyl-prolyl isomerase essential for regulation of mitosis

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Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism

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Pinning down proline-directed phosphorylation signaling

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7 January 2021

The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein

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7 January 2021

Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins

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7 January 2021

Inverse association of Pin1 and tau accumulation in Alzheimer's disease hippocampus

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7 January 2021

The effect of age and Alzheimer's disease on pyramidal neuron density in the individual fields of the hippocampal formation

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7 January 2021

Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes

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7 January 2021

Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases.

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A neuronal antigen in the brains of Alzheimer patients

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A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

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7 January 2021

Conformation of paired helical filaments blocks dephosphorylation of epitopes shared with fetal tau except Ser199/202 and Ser202/Thr205.

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7 January 2021

Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G(0) arrest.

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7 January 2021

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

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Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

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7 January 2021